Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Assaf, Rudich"'
Autor:
Gil Sorek, Yulia Haim, Vered Chalifa-Caspi, Or Lazarescu, Maya Ziv-Agam, Tobias Hagemann, Pamela Arielle Nono Nankam, Matthias Blüher, Idit F. Liberty, Oleg Dukhno, Ivan Kukeev, Esti Yeger-Lotem, Assaf Rudich, Liron Levin
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110368- (2024)
Summary: Deconvolution algorithms mostly rely on single-cell RNA-sequencing (scRNA-seq) data applied onto bulk RNA-sequencing (bulk RNA-seq) to estimate tissues’ cell-type composition, with performance accuracy validated on deposited databases. Adi
Externí odkaz:
https://doaj.org/article/120ff37dd2ea4aedb2a1d37c407109f6
Autor:
Fabrizio C. Lucchini, Stephan Wueest, Tenagne D. Challa, Flurin Item, Salvatore Modica, Marcela Borsigova, Yulia Haim, Christian Wolfrum, Assaf Rudich, Daniel Konrad
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Understanding the regulatory mechanisms governing brown and beige adipose mediated thermogenesis is of interest in order to develop therapeutic strategies to treat obesity. Here, the authors show that adipocyte-expressed apoptosis signal-regulating k
Externí odkaz:
https://doaj.org/article/a5f0fcf02ab1420cbe65f5ab4e73cc5e
Autor:
Yair Pincu, Uri Yoel, Yulia Haim, Nataly Makarenkov, Nitzan Maixner, Ruthy Shaco-Levy, Nava Bashan, Dror Dicker, Assaf Rudich
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Obesity is a heterogenous condition that affects the life and health of patients to different degrees and in different ways. Yet, most approaches to treat obesity are not currently prescribed, at least in a systematic manner, based on individual obes
Externí odkaz:
https://doaj.org/article/cd88a948510c4918a4ec8a488dc8efd8
Autor:
Nikhil S. Bhandarkar, Rotem Lahav, Nitzan Maixner, Yulia Haim, G. William Wong, Assaf Rudich, Uri Yoel
Publikováno v:
Physiological Reports, Vol 9, Iss 18, Pp n/a-n/a (2021)
Abstract In humans, exercise‐induced thermogenesis is a markedly variable component of total energy expenditure, which had been acutely affected worldwide by COVID‐19 pandemic‐related lockdowns. We hypothesized that dietary macronutrient compos
Externí odkaz:
https://doaj.org/article/dec19c05b81a4ec99b18049e4d7b58cf
Publikováno v:
Adipocyte, Vol 9, Iss 1, Pp 535-541 (2020)
Increasing energy expenditure via induction of browning in white adipose tissue has emerged as a potential strategy to treat obesity and associated metabolic complications. We previously reported that ASK1 inhibition in adipocytes protected from high
Externí odkaz:
https://doaj.org/article/0d43f3fd018043709c85663053d6a064
Autor:
Nitzan Maixner, Yulia Haim, Matthias Blüher, Vered Chalifa-Caspi, Isana Veksler-Lublinsky, Nataly Makarenkov, Uri Yoel, Nava Bashan, Idit F. Liberty, Ivan Kukeev, Oleg Dukhno, Dan Levy, Assaf Rudich
Publikováno v:
Cells, Vol 11, Iss 19, p 3046 (2022)
Objective: Up-regulated expression of transcription-factor E2F1 in human visceral adipose tissue (VAT) characterizes a dysmetabolic obesity sub-phenotype. An E2F1-miRNA network has been described in multiple cancers. Here we investigated whether elev
Externí odkaz:
https://doaj.org/article/b7c7f7c5abb64bbfb1bccaf79968ec5a
Autor:
Kathrin Landgraf, Nora Klöting, Martin Gericke, Nitzan Maixner, Esther Guiu-Jurado, Markus Scholz, A. Veronica Witte, Frauke Beyer, Julian T. Schwartze, Martin Lacher, Arno Villringer, Peter Kovacs, Assaf Rudich, Matthias Blüher, Wieland Kiess, Antje Körner
Publikováno v:
Cell Reports, Vol 33, Iss 3, Pp 108295- (2020)
Summary: TMEM18 is the strongest candidate for childhood obesity identified from GWASs, yet as for most GWAS-derived obesity-susceptibility genes, the functional mechanism remains elusive. We here investigate the relevance of TMEM18 for adipose tissu
Externí odkaz:
https://doaj.org/article/e94fd22e090f4168b9d67fd8be7d39de
Autor:
Nir Goldstein, Yulia Haim, Pamela Mattar, Sapir Hadadi-Bechor, Nitzan Maixner, Peter Kovacs, Matthias Blüher, Assaf Rudich
Publikováno v:
Adipocyte, Vol 8, Iss 1, Pp 51-60 (2019)
Obesity, a condition most commonly associated with hyper-leptinemia, is also characterized by increased expression of autophagy genes and likely autophagic activity in human adipose tissue (AT). Indeed, circulating leptin levels were previously shown
Externí odkaz:
https://doaj.org/article/7504f862a8044f4a8d5db64dafc39620
Autor:
Yulia Haim, Matthias Blüher, Daniel Konrad, Nir Goldstein, Nora Klöting, Ilana Harman-Boehm, Boris Kirshtein, Doron Ginsberg, Tanya Tarnovscki, Yftach Gepner, Iris Shai, Assaf Rudich
Publikováno v:
Molecular Metabolism, Vol 6, Iss 7, Pp 725-736 (2017)
Objective: Obesity variably disrupts human health, but molecular-based patients' health-risk stratification is limited. Adipose tissue (AT) stresses may link obesity with metabolic dysfunction, but how they signal in humans remains poorly-characteriz
Externí odkaz:
https://doaj.org/article/a6e72e1ef48b40659e43d1e99c48e107
Autor:
Nir Goldstein, Yarden Kezerle, Yftach Gepner, Yulia Haim, Tal Pecht, Roi Gazit, Vera Polischuk, Idit F. Liberty, Boris Kirshtein, Ruthy Shaco-Levy, Matthias Blüher, Assaf Rudich
Publikováno v:
Cells, Vol 9, Iss 6, p 1508 (2020)
The identification of human obesity sub-types may improve the clinical management of patients with obesity and uncover previously unrecognized obesity mechanisms. Here, we hypothesized that adipose tissue (AT) mast cells (MC) estimation could be a ma
Externí odkaz:
https://doaj.org/article/46e27ae48cf3463c8a26f5e0f1995839