Synthesis of enones, pyrazolines and pyrrolines with gem-difluoroalkyl side chains

Autor: Assaad Nasr El Dine, Ali Khalaf, Danielle Grée, Olivier Tasseau, Fares Fares, Nada Jaber, Philippe Lesot, Ali Hachem, René Grée

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 9, Iss 1, Pp 1943-1948 (2013)

Starting from easily accessible gem-difluoropropargylic derivatives, a DBU-mediated isomerisation affords enones in fair yields with a gem-difluoroalkyl chain. These derivatives were used to prepare pyrazolines and pyrrolines with the desired gem-dif

Externí odkaz: https://doaj.org/article/ba12495f2fd84577a917bba9c8df2a43

Structural revision of the Mcl-1 inhibitor MIM1: synthesis and biological studies on ovarian cancer cells with evaluation of designed analogues

Autor: Hippolyte Paysant, Jérôme Bignon, Marie Jouanne, Christophe Denoyelle, Assaad Nasr El Dine, Anne Sophie Voisin-Chiret, Louis Bastien Weiswald, Olivier Tasseau, Nicolas Elie, Siham Hedir, Frédéric Justaud, Thierry Roisnel, Ali Hachem, Emilie Brotin, Laurent Poulain, Fanny Roussi, René Grée, Ali Soulieman, Nicolas Levoin

Publikováno v: Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2021, 19 (41), pp.8968-8987. ⟨10.1039/d1ob01521d⟩
Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry, 2021, 19 (41), pp.8968-8987. ⟨10.1039/d1ob01521d⟩

International audience; In the area of cancer research, the development of new and potent inhibitors of anti-apoptotic proteins is a very active and promising topic. The small molecule MIM1 has been reported earlier as one of the first selective inhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d101b994a857dd58e56594e3c84c017c
https://doi.org/10.1039/d1ob01521d

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A thiosemicarbazone derivative induces triple negative breast cancer cell apoptosis possible role of miRNA-125a-5p and miRNA-181a-5p

Autor: Bassam Badran, Hussein Fayyad-Kazan, Eva Hamade, Rabih S. Talhouk, Mohammad Fayyad-Kazan, Rawan Makki, Ali Hachem, René Grée, Rania El Majzoub, Assaad Nasr El Dine

Publikováno v: Genes and Genomics
Genes and Genomics, 2019, 41 (12), pp.1431-1443. ⟨10.1007/s13258-019-00866-y⟩

International audience; Background - Breast cancer, the most commonly diagnosed malignancy in women, accounts for the highest cancer-related deaths worldwide. Triple negative breast cancer (TNBC), lacking the expression of estrogen, progesterone and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a3fa07d19b0786daadb467850575a44
https://hal-univ-rennes1.archives-ouvertes.fr/hal-02307029

ChemInform Abstract: A New Direct Synthesis of α-Methylene- and α-Alkylidene-β-lactams

Autor: Ali Hachem, René Grée, Vincent Dorcet, Assaad Nasr El Dine, Fares A. Fares, Marwa Hussein

Publikováno v: ChemInform. 47

The Kinugasa reaction applied to alkynes bearing a nucleofuge in propargylic position affords directly, and in fair yields, α-methylene- or α-alkylidene-β-lactams.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c09e5dc29484e404f0b4b6824d0524a6
https://doi.org/10.1002/chin.201633119