Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Assa Sittner"'
Autor:
Itai Glinert, Elad Bar-David, Amir Ben-Shmuel, Assa Sittner, Reut Puni, Shira Laredo, David Kobiler, Shay Weiss, Haim Levy
Publikováno v:
PLoS ONE, Vol 18, Iss 2 (2023)
Bacillus anthracis overcomes host immune responses by producing capsule and secreting toxins. Production of these virulence factors in response to entering the host environment was shown to be regulated by atxA, the major virulence regulator, known t
Externí odkaz:
https://doaj.org/article/d3dbd8eaf44049c39ae0a47d334aecd5
Autor:
Yfat Yahalom-Ronen, Hadas Tamir, Sharon Melamed, Boaz Politi, Ohad Shifman, Hagit Achdout, Einat B. Vitner, Ofir Israeli, Elad Milrot, Dana Stein, Inbar Cohen-Gihon, Shlomi Lazar, Hila Gutman, Itai Glinert, Lilach Cherry, Yaron Vagima, Shirley Lazar, Shay Weiss, Amir Ben-Shmuel, Roy Avraham, Reut Puni, Edith Lupu, Elad Bar-David, Assa Sittner, Noam Erez, Ran Zichel, Emanuelle Mamroud, Ohad Mazor, Haim Levy, Orly Laskar, Shmuel Yitzhaki, Shmuel C. Shapira, Anat Zvi, Adi Beth-Din, Nir Paran, Tomer Israely
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Here, the authors generate a replication-competent VSV based vaccine expressing SARS-CoV-2 spike protein and show protection in the hamster model with one dose. Analysis of the antibody response in mice shows induction of neutralizing antibodies and
Externí odkaz:
https://doaj.org/article/c9dbfd8736364f25b7884f0d5634e9e1
Autor:
Morly Fisher, Haim Levy, Ella Fatelevich, Yafa Afrimov, Amir Ben-Shmuel, Ronit Rosenfeld, Tal Noy-Porat, Itai Glinert, Assa Sittner, Asaf Biber, Ana Belkin, Elad Bar-David, Reut Puni, Itzchak Levy, Ohad Mazor, Shay Weiss, Adva Mechaly
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 2 (2021)
ABSTRACT The first case of SARS-CoV-2 was discovered in Israel in late February 2020. Three major outbreaks followed, resulting in over 800,000 cases and over 6,000 deaths by April 2021. Our aim was characterization of a serological snapshot of Israe
Externí odkaz:
https://doaj.org/article/15a464bd53ad4ce7b06623c164ed91d9
Autor:
Assa Sittner, Amir Ben-Shmuel, Itai Glinert, Elad Bar-David, Josef Schlomovitz, David Kobiler, Shay Weiss, Haim Levy
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0228917 (2020)
As Bacillus anthracis spores pose a proven bio-terror risk, the treatment focus has shifted from exposed populations to anthrax patients and the need for effective antibiotic treatment protocols increases. The CDC recommends carbapenems and Linezolid
Externí odkaz:
https://doaj.org/article/c1cb41eeaf8d4463ad522325c9628569
Autor:
Chaja Katzman, Tomer Israely, Sharon Melamed, Boaz Politi, Assa Sittner, Yfat Yahalom-Ronen, Shay Weiss, Reem Abu Rass, Rachel Zamostiano, Eran Bacharach, Marcelo Ehrlich, Nir Paran, Lior Nissim
Publikováno v:
Viruses, Vol 14, Iss 1, p 11 (2021)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a severe global pandemic. Mice models are essential to investigate infection pathology, antiviral drugs, and vaccine development. However, wild-type mice lack the human angiotensin-c
Externí odkaz:
https://doaj.org/article/0780ad5682be4f9aad0d4ef6f826a095
Autor:
Adva Mechaly, Einat B. Vitner, Yinon Levy, David Gur, Moria Barlev-Gross, Assa Sittner, Michal Koren, Haim Levy, Emanuelle Mamroud, Morly Fisher
Publikováno v:
Pathogens, Vol 10, Iss 3, p 285 (2021)
Mouse monoclonal antibodies were raised against plague disease biomarkers: the bacterial capsular protein fraction 1 (F1) and the low-calcium response—LcrV virulence factor (Vag). A novel tandem assay, employing BioLayer Interferometry (BLI), enabl
Externí odkaz:
https://doaj.org/article/c857d46183084f8b9b0b846777cc04da
Autor:
Assa Sittner, Elad Bar-David, Itai Glinert, Amir Ben-Shmuel, Shay Weiss, Josef Schlomovitz, David Kobiler, Haim Levy
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186613 (2017)
Hemorrhagic meningitis is considered a complication of anthrax and was reported in about 50% of deadly cases in humans and non-human primates (NHP). Recently we demonstrated in Guinea pigs and rabbits that 100% of the B. anthracis-infected animals pr
Externí odkaz:
https://doaj.org/article/2532610b89de48649628194738593a25
Autor:
Itai Glinert, Shay Weiss, Assa Sittner, Elad Bar-David, Amir Ben-Shmuel, Josef Schlomovitz, David Kobiler, Haim Levy
Publikováno v:
Toxins, Vol 10, Iss 12, p 506 (2018)
Nonencapsulated (∆pXO2) Bacillus anthracis strains are commonly used as vaccines and for anthrax research, mainly in the mouse model. Previously, we demonstrated that the infection of rabbits, intranasally or subcutaneously, with the spores of a fu
Externí odkaz:
https://doaj.org/article/bb9889009db04113af35fc3d83d0272e
Autor:
Haim Levy, Itai Glinert, Shay Weiss, Elad Bar-David, Assa Sittner, Josef Schlomovitz, Zeev Altboum, David Kobiler
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112319 (2014)
Infection of the central nervous system is considered a complication of Anthrax and was reported in humans and non-human primates. Previously we have reported that Bacillus anthracis possesses a toxin-independent virulent trait that, like the toxins,
Externí odkaz:
https://doaj.org/article/31639f4b799a4a1eb5cc529661a23238
Autor:
Haim Levy, Itai Glinert, Shay Weiss, Assa Sittner, Josef Schlomovitz, Zeev Altboum, David Kobiler
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e84947 (2014)
The accepted paradigm states that anthrax is both an invasive and toxinogenic disease and that the toxins play a major role in pathogenicity. In the guinea pig (GP) model we have previously shown that deletion of all three toxin components results in
Externí odkaz:
https://doaj.org/article/df58a90deb9f4c7eac39125882a316f8