Zobrazeno 1 - 10
of 631
pro vyhledávání: '"Asrar B. Malik"'
Autor:
Chinnaswamy Tiruppathi, Dong-Mei Wang, Mohammad Owais Ansari, Shabana Bano, Yoshikazu Tsukasaki, Amitabha Mukhopadhyay, Jagdish C. Joshi, Christian Loch, Hans W. M. Niessen, Asrar B. Malik
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Vascular endothelial cadherin (VE-cadherin) expressed at endothelial adherens junctions (AJs) is vital for vascular integrity and endothelial homeostasis. Here we identify the requirement of the ubiquitin E3-ligase CHFR as a key mechanism of
Externí odkaz:
https://doaj.org/article/bd6da7d597ac42feba25fde2e33ebb02
Autor:
Dianicha Santana Nunez, Asrar B. Malik, Quinn Lee, Sang Joon Ahn, Arnold Coctecon-Murillo, Dana Lazarko, Irena Levitan, Dolly Mehta, Yulia A. Komarova
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108633- (2024)
Externí odkaz:
https://doaj.org/article/116d5e156b164878abdebb51b7c70bda
Autor:
Luyang Cao, Lixiang Ma, Juan Zhao, Xiangyu Wang, Xinzou Fang, Wei Li, Yawen Qi, Yingkui Tang, Jieya Liu, Shengxian Peng, Li Yang, Liangxue Zhou, Li Li, Xiaobo Hu, Yuan Ji, Yingyong Hou, Yi Zhao, Xianming Zhang, You-yang Zhao, Yong Zhao, Yuquan Wei, Asrar B Malik, Hexige Saiyin, Jingsong Xu
Publikováno v:
eLife, Vol 12 (2023)
Billions of apoptotic cells are removed daily in a human adult by professional phagocytes (e.g. macrophages) and neighboring nonprofessional phagocytes (e.g. stromal cells). Despite being a type of professional phagocyte, neutrophils are thought to b
Externí odkaz:
https://doaj.org/article/26dc4a5f54e64fc6b2281fc82176b8e2
Autor:
Lianghui Zhang, Krishna K Narayanan, Laura Cooper, Kui K Chan, Savanna S Skeeters, Christine A Devlin, Aaron Aguhob, Kristie Shirley, Lijun Rong, Jalees Rehman, Asrar B Malik, Erik Procko
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 11, Pp 1-17 (2022)
Abstract Monoclonal antibodies targeting the SARS‐CoV‐2 spike (S) neutralize infection and are efficacious for the treatment of COVID‐19. However, SARS‐CoV‐2 variants, notably sublineages of B.1.1.529/omicron, have emerged that escape antib
Externí odkaz:
https://doaj.org/article/8fa757d137e84ac4a868e7623dd8c34d
Autor:
Long Shuang Huang, Mohammad Anas, Jingsong Xu, Bisheng Zhou, Peter T Toth, Yamuna Krishnan, Anke Di, Asrar B Malik
Publikováno v:
eLife, Vol 12 (2023)
Potassium efflux via the two-pore K+ channel TWIK2 is a requisite step for the activation of NLRP3 inflammasome, however, it remains unclear how K+ efflux is activated in response to select cues. Here, we report that during homeostasis, TWIK2 resides
Externí odkaz:
https://doaj.org/article/75d2cdbd728d41c58901e431b8274cbb
Autor:
Dianicha Santana Nunez, Asrar B. Malik, Quinn Lee, Sang Joon Ahn, Arnold Coctecon-Murillo, Dana Lazarko, Irena Levitan, Dolly Mehta, Yulia A. Komarova
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106661- (2023)
Summary: Endothelial cells (ECs) continuously sense and adapt to changes in shear stress generated by blood flow. Here, we show that the activation of the mechanosensitive channel Piezo1 by defined shear forces induces Ca2+ entry into the endoplasmic
Externí odkaz:
https://doaj.org/article/52fbd5ae088f48cf9672d032f91de5a1
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
During pyroptosis, gasdermin D (GSDMD) forms plasma membrane pores that initiate cell lysis. Here, the authors develop optogenetically activatable human GSDMD to assess GSDMD pore behavior and show that they are dynamic and can close, which can be a
Externí odkaz:
https://doaj.org/article/74ba8d66e6d24b648cd298d1979af553
Autor:
Shiqin Xiong, Zhigang Hong, Long Shuang Huang, Yoshikazu Tsukasaki, Saroj Nepal, Anke Di, Ming Zhong, Wei Wu, Zhiming Ye, Xiaopei Gao, Gadiparthi N. Rao, Dolly Mehta, Jalees Rehman, Asrar B. Malik
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 5 (2023)
Externí odkaz:
https://doaj.org/article/1386416942cc420f876ffcf79a536800
Publikováno v:
JCI Insight, Vol 7, Iss 11 (2022)
Studies have demonstrated the phenotypic heterogeneity of vascular endothelial cells (ECs) within a vascular bed; however, little is known about how distinct endothelial subpopulations in a particular organ respond to an inflammatory stimulus. We per
Externí odkaz:
https://doaj.org/article/0f1177fab8254e33bce35cceb9c0fc9a
Autor:
Zhiming Ye, Li Zhang, Ruizhao Li, Wei Dong, Shuangxin Liu, Zhilian Li, Huaban Liang, Lifen Wang, Wei Shi, Asrar B. Malik, Kwong Tai Cheng, Xinling Liang
Publikováno v:
Kidney & Blood Pressure Research, Pp 1-14 (2019)
Background/Aims: Acute kidney injury (AKI) is a serious complication of sepsis and has a high morbidity and mortality rate. Caspase-11 induces pyroptosis, a form of programmed cell death that plays a critical role in endotoxic shock, but its role in
Externí odkaz:
https://doaj.org/article/df5ab949702c44b69d220ba8bd58ca51