Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Asparouh Lilov"'
Autor:
Michael E Brown, Daniel Bedinger, Asparouh Lilov, Palaniswami Rathanaswami, Maximiliano Vásquez, Stéphanie Durand, Ian Wallace-Moyer, Lihui Zhong, Juergen H Nett, Irina Burnina, Isabelle Caffry, Heather Lynaugh, Melanie Sinclair, Tingwan Sun, John Bukowski, Yingda Xu, Yasmina Noubia Abdiche
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0229206 (2020)
Here we describe an industry-wide collaboration aimed at assessing the binding properties of a comprehensive panel of monoclonal antibodies (mAbs) against programmed cell death protein 1 (PD-1), an important checkpoint protein in cancer immunotherapy
Externí odkaz:
https://doaj.org/article/fc8fd2aadbea4beb830fe69ba9587bcc
Autor:
Laila Shehata, Daniel P. Maurer, Anna Z. Wec, Asparouh Lilov, Elizabeth Champney, Tingwan Sun, Kimberly Archambault, Irina Burnina, Heather Lynaugh, Xiaoyong Zhi, Yingda Xu, Laura M. Walker
Publikováno v:
Cell Reports, Vol 28, Iss 13, Pp 3300-3308.e4 (2019)
Summary: Monoclonal antibodies (mAbs) have recently emerged as one of the most promising classes of biotherapeutics. A potential advantage of B cell-derived mAbs as therapeutic agents is that they have been subjected to natural filtering mechanisms,
Externí odkaz:
https://doaj.org/article/fd7608d185584ab3a6267b03c19f18e7
Autor:
Laura M. Walker, Kimberly Archambault, Elizabeth Champney, Asparouh Lilov, Anna Z. Wec, Xiaoyong Zhi, Heather Lynaugh, Laila Shehata, Yingda Xu, Tingwan Sun, Daniel P. Maurer, Irina Burnina
Publikováno v:
Cell Reports, Vol 28, Iss 13, Pp 3300-3308.e4 (2019)
Summary: Monoclonal antibodies (mAbs) have recently emerged as one of the most promising classes of biotherapeutics. A potential advantage of B cell-derived mAbs as therapeutic agents is that they have been subjected to natural filtering mechanisms,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33fca4c168732760495a288c1fe28829
http://www.sciencedirect.com/science/article/pii/S2211124719311040
http://www.sciencedirect.com/science/article/pii/S2211124719311040
Autor:
Anna Z. Wec, Daniel Wrapp, Andrew S. Herbert, Daniel Maurer, Denise Haslwanter, Mrunal Sakharkar, Rohit K. Jangra, M. Eugenia Dieterle, Asparouh Lilov, Deli Huang, Longping V. Tse, Nicole V. Johnson, Ching-Lin Hsieh, Nianshuang Wang, Juergen H. Nett, Elizabeth Champney, Irina Burnina, Michael Brown, Shu Lin, Melanie Sinclair, Carl Johnson, Sarat Pudi, Robert Bortz, Ariel S. Wirchnianski, Ethan Laudermilch, Catalina Florez, J. Maximilian Fels, Cecilia M. O’Brien, Barney S. Graham, David Nemazee, Dennis R. Burton, Ralph S. Baric, James E. Voss, Kartik Chandran, John M. Dye, Jason S. McLellan, Laura M. Walker
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 2
article-version (status) pre
article-version (number) 2
Broadly protective vaccines against known and pre-emergent coronaviruses are urgently needed. Critical to their development is a deeper understanding of cross-neutralizing antibody responses induced by natural human coronavirus (HCoV) infections. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c228fd092ccaf8df50d53fad057ba17d
https://pubmed.ncbi.nlm.nih.gov/32511337
https://pubmed.ncbi.nlm.nih.gov/32511337
Autor:
Laura M. Walker, Mrunal Sakharkar, Ching-Lin Hsieh, Kartik Chandran, Ethan Laudermilch, Ariel S. Wirchnianski, Barney S. Graham, Daniel P. Maurer, Deli Huang, Sarat Pudi, John M. Dye, Elizabeth Champney, Asparouh Lilov, James E. Voss, David Nemazee, Melanie Sinclair, Catalina Florez, Denise Haslwanter, Jason S. McLellan, M. Eugenia Dieterle, Dennis R. Burton, Andrew S. Herbert, Ralph S. Baric, Irina Burnina, Nicole V. Johnson, Anna Z. Wec, Longping V. Tse, Daniel Wrapp, Rohit K. Jangra, Nianshuang Wang, Cecilia M. O’Brien, Shu Lin, Juergen Hermann Nett, J. Maximilian Fels, Carl Hirschie Johnson, Michael G. Brown, Robert H. Bortz
Publikováno v:
Science (New York, N.y.)
Science
Science
Seeking broad protection As scientists develop therapeutic antibodies and vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the risk of emergent coronaviruses makes it important to also identify broadly protective antibod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d3e3cabb099d8368b3a9a28cca1fe8a
http://europepmc.org/articles/PMC7299279
http://europepmc.org/articles/PMC7299279
Autor:
Irina Burnina, Yasmina Noubia Abdiche, Juergen Hermann Nett, Michael Brown, Melanie Sinclair, Yingda Xu, Asparouh Lilov, Isabelle Caffry, Ian Wallace-Moyer, Maximiliano Vásquez, Tingwan Sun, Lihui Zhong, Heather Lynaugh, Palaniswami Rathanaswami, John Bukowski, Stéphanie Durand, Daniel Bedinger
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0229206 (2020)
PLoS ONE
PLoS ONE
Here we describe an industry-wide collaboration aimed at assessing the binding properties of a comprehensive panel of monoclonal antibodies (mAbs) against programmed cell death protein 1 (PD-1), an important checkpoint protein in cancer immunotherapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aaf63a42deea692e0f0393ebf753939
https://doaj.org/article/fc8fd2aadbea4beb830fe69ba9587bcc
https://doaj.org/article/fc8fd2aadbea4beb830fe69ba9587bcc
Autor:
Jimin Wang, Tara Sprules, Marta Vranas, Asparouh Lilov, Kalle Gehring, Marjan Seirafi, Shafqat Rasool, Véronique Sauvé, Guennadi Kozlov, Jean-François Trempe
Publikováno v:
The EMBO Journal. 34:2492-2505
Mutations in Parkin and PINK1 cause an inherited early-onset form of Parkinson's disease. The two proteins function together in a mitochondrial quality control pathway whereby PINK1 accumulates on damaged mitochondria and activates Parkin to induce m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c3191056155d13418be6244d6440398
https://doi.org/10.15252/embj.201592237
https://doi.org/10.15252/embj.201592237
Autor:
Yingda Xu, Cody Williams, Tingwan Sun, Patricia Estep, Asparouh Lilov, Irina Burnina, Kirt Johnson, Chris Sumner, Yao Yu, Heather Lynaugh, R. Paul Nobrega, Jonathan P. Belk, Jordan Desroches, Isabelle Caffry, John Bukowski, Michael G. Brown
Publikováno v:
SLAS technology. 22(5)
The state-of-the-art industrial drug discovery approach is the empirical interrogation of a library of drug candidates against a target molecule. The advantage of high-throughput kinetic measurements over equilibrium assessments is the ability to mea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155ebc07590a257476ffb2636881ae90
https://pubmed.ncbi.nlm.nih.gov/28430560
https://pubmed.ncbi.nlm.nih.gov/28430560
Autor:
Asparouh Lilov, Maximiliano Vásquez, Todd Boland, Tushar Jain, Michael G. Brown, Yingda Xu, Irina Burnina
Publikováno v:
Bioinformatics (Oxford, England). 33(23)
Motivation The hydrophobicity of a monoclonal antibody is an important biophysical property relevant for its developability into a therapeutic. In addition to characterizing heterogeneity, Hydrophobic Interaction Chromatography (HIC) is an assay that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c56afb659e3f45c3558175aaecf0059
https://pubmed.ncbi.nlm.nih.gov/28961999
https://pubmed.ncbi.nlm.nih.gov/28961999
Autor:
R. Paul Nobrega, Tingwan Sun, Todd Boland, Asparouh Lilov, Michael Brown, Yingda Xu, Xiaoyong Zhi, Rong Yang, Isabelle Caffry, Irina Burnina, Xiaojun Lu, Heather Lynaugh, Tushar Jain
Publikováno v:
mAbs. 9(4)
Susceptibility of methionine to oxidation is an important concern for chemical stability during the development of a monoclonal antibody (mAb) therapeutic. To minimize downstream risks, leading candidates are usually screened under forced oxidation c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::109685fb4c0495456fd5800f5d2a0b50
https://pubmed.ncbi.nlm.nih.gov/28281887
https://pubmed.ncbi.nlm.nih.gov/28281887