Tumor Preventive Efficacy of Emodin in 7,12-Dimethylbenz[a]Anthracene-Induced Oral Carcinogenesis: a Histopathological and Biochemical Approach

Autor: Shanmugam Manoharan, Asokan Manimaran

Publikováno v: Pathology & Oncology Research. 24:19-29

The aim of the present study is to focus the chemopreventive potential of Emodin during 7,12-dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch carcinogenesis. Tumors were developed in the buccal pouches of golden Syrian hamsters by painti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3287f946b3fef7a0bdef28a087b99c9e
https://doi.org/10.1007/s12253-017-0205-7

EMODIN EFFICACY ON THE AKT, MAPK, ERK AND DNMT EXPRESSION PATTERN DURING DMBA-INDUCED ORAL CARCINOMA IN GOLDEN SYRIAN HAMSTERS

Autor: Asokan Manimaran, Mani Neelakandan, Shanmugam Manoharan

Publikováno v: African Journal of Traditional, Complementary and Alternative Medicines; Vol 13, No 6 (2016); 186-193
African Journal of Traditional, Complementary, and Alternative Medicines

Background: The present study has evaluated the Emodin efficacy on the Akt, MAPK, ERK and DNMT expression pattern during 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinoma in golden Syrian hamsters, in order to explore its antitumor potenti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b15d761b5cc0b98335dc8bffdefd604
https://doi.org/10.21010/ajtcam.v13i6.27

Modulating Effect of Ferulic Acid on NF-kB, COX-2 and VEGF Expression Pattern During 7, 12-Dimethylbenz(a)anthracene Induced Oral Carcinogenesis

Autor: Tharmaraj Rejitharaji, Ram B. Singh, Murugaraj Manoj Prabhakar, Asokan Manimaran, Shanmugam Manoharan

Publikováno v: The Open Nutraceuticals Journal. 7:33-38

Ferulic acid, a natural antioxidant, has the potential to prevent inflammation and to modulate angiogenesis in both in vivo and in vitro models. The present study has investigated the modulating effect of ferulic acid on the expression pattern of COX

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a3c4f2707b6f142cd4b15f3ac709d3b8
https://doi.org/10.2174/1876396001407010033

Modulating Effect of Enicostemma littorale on the Expression Pattern of Apoptotic, Cell Proliferative, Inflammatory and Angiogenic Markers During 7, 12-Dimethylbenz (a) Anthracene Induced Hamster Buccal Pouch Carcinogenesis

Autor: Sekar Karthikeyan, Shanmugam Manoharan, Murugaraj Manoj Prabhakar, Duraisamy Rajasekaran, Asokan Manimaran

Publikováno v: Toxicology International

Enicostemma littorale leaves are traditionally used for the treatment of several diseases, including inflammation and cancer. This study has taken effort to explore the antitumor initiating potential of E. littorale leaves (ElELet) by analyzing the e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78ef86edfdc4f97fecd35655a4bb151a
https://pubmed.ncbi.nlm.nih.gov/26862274

Enicostemma littorale prevents tumor formation in 7,12-dimethylbenz(a)anthracene-induced hamster buccal pouch carcinogenesis

Autor: Duraisamy Rajasekaran, Shanmugam Manoharan, Murugaraj Manoj Prabhakar, Asokan Manimaran

Publikováno v: Humanexperimental toxicology. 34(9)

Oral cancer is one of the most common malignancies worldwide, and India has recorded the highest annual incidence of oral cancer in comparison with other countries. Altered lipid peroxidation and antioxidant status along with defect in detoxification

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f5bd00f9d216daf85f77d11557a0d72
https://pubmed.ncbi.nlm.nih.gov/26286523