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Akademický článek

Design and synthesis of novel quinazolinones conjugated ibuprofen, indole acetamide, or thioacetohydrazide as selective COX-2 inhibitors: anti-inflammatory, analgesic and anticancer activities

Autor: Asmaa Sakr, Samar Rezq, Samy M. Ibrahim, Eman Soliman, Mohamed M. Baraka, Damian G. Romero, Hend Kothayer

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1810-1828 (2021)

Novel quinazolinones conjugated with indole acetamide (4a–c), ibuprofen (7a–e), or thioacetohydrazide (13a,b, and 14a-d) were designed to increase COX-2 selectivity. The three synthesised series exhibited superior COX-2 selectivity compared with

Externí odkaz: https://doaj.org/article/3fdf57b999254bc881704aae6459b290

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The neuroprotective effect of a novel 1,4‐Dihydroquinazolin‐3(2H)‐yl benzamide derivative against chronic constriction injury‐induced neuropathic pain in rats

Autor: Samar Rezq, Asmaa Sakr, Hend Kothayer, Nancy H. Hassan, Amira Alsemeh

Publikováno v: The FASEB Journal. 36

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::28e25d9f815d9ea835a28b1e4cf4f9be
https://doi.org/10.1096/fasebj.2022.36.s1.r6301

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1,4-Dihydroquinazolin-3(2H)-yl benzamide derivatives as anti-inflammatory and analgesic agents with an improved gastric profile: Design, synthesis, COX-1/2 inhibitory activity and molecular docking study

Autor: Samar Rezq, Samy M. Ibrahim, Asmaa Sakr, Hend Kothayer, Mohamed M. Baraka

Publikováno v: Bioorganic Chemistry. 84:76-86

The design and synthesis of a new series of 1,4-dihydroquinazolin-3(2H)-yl benzamide derivatives (4a–o) as anti-inflammatory and analgesic agents and COX-1/2 inhibitors are reported. The target compounds (4a–o) were synthesized using a two-step s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e550ef4a4a0d1003313462b6b1237489
https://doi.org/10.1016/j.bioorg.2018.11.030

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Improving MOOCs experience using Learning Analytics and Intelligent Conversational Agent

Autor: Tariq Abdullah, Asmaa Sakr

Online learning has proved its effectiveness in the last few years among a wide range of learners. Massive Open Online Courses (MOOCs) have revolutionized the shape of learning because they are considered to be a substitutional tool to the convention

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6dd108b4a2c676d756c2e6a123534747
https://doi.org/10.1016/b978-0-12-823410-5.00010-3

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List of contributors

Autor: Tariq Abdullah, Héctor R. Amado-Salvatierra, Amara Atif, Mireille Avigal, Rina Azoulay, Mammed Bagher, Samir Bennani, Ayse A. Bilgin, Regina Braga, François Bry, Santi Caballé, Fernanda Campos, Nicola Capuano, Joan Casas-Roma, Jordi Conesa, Mário Dantas, Thanasis Daradoumis, Esther David, José Maria N. David, Stavros Demetriadis, Nourredine EL Faddouli, Michalis Feidakis, Eleni Fotopoulou, Eduardo Gómez-Sánchez, Isaac Muro Guiu, Abdelladim Hadioui, Niels Heller, Rocael Hernández Rizzardini, Matthew Hodges, Dorit Hutzler, Debora Jeske, Meena Jha, Anastasios Karakostas, Allison Kolling, Kristijan Kuk, Jianxin Li, Edis Meki, Konstantinos Michos, Miguel Morales Chan, Felipe Neves, Nadia Pantidi, George Palaigeorgiou, Pantelis M. Papadopoulos, Symeon Papavassiliou, Tijana Paunovi, Georgios Psathas, Deborah Richards, Asmaa Sakr, Xiangyu Song, Victor Ströele, Stergios Tegos, Yassine Benjelloun Touimi, Thrasyvoulos Tsiatsos, Costas Tsibanis, Igor Vukovi, Armin Weinberger, Christian Winther Bech, John Yoon, Anastasios Zafeiropoulos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e82b83f1c88618ce5f668a8d23c17758
https://doi.org/10.1016/b978-0-12-823410-5.00024-3

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