Výsledky vyhledávání - "Asmaa Mohamed Atta"

Recent insight into BACE1 as a potential target for treatment of Alzheimer's disease

Autor: Mohamed Saleh Elgawish, Khaled M. Darwish, Asmaa Mohamed Atta, Mohamed aboelhassan Helal, Samia Mahmoud Moustafa

Publikováno v: Records of Pharmaceutical and Biomedical Sciences. 5:100-111

Alzheimer’s disease (AD) is one of the most common progressive neurodegenerative diseases that represents about 60-80 % of total cases of dementia all over the world. Beta secretase (BACE1) is a membrane-anchored aspartic protease which cleaves the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::907bc95ea83e5c57a5216698eb47c14c
https://doi.org/10.21608/rpbs.2021.55758.1087

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Discovery of tetrahydro-β-carboline- and indole-based derivatives as promising phosphodiesterase-4 inhibitors: Synthesis, biological evaluation, and molecular modeling studies

Autor: Khaled M. Darwish, Mohamed A. Helal, Ahmad Abdelwaly, Asmaa Mohamed Atta

Publikováno v: Journal of Molecular Structure. 1248:131491

Phosphodiesterase-4 (PDE4) is responsible for the selective degradation of the 3ʹ-cyclic phosphate bonds of cAMP. A collection of twenty-three diverse 1,2,3,4-tertahydro-β-carboline- and indole-based analogues were synthesized and assessed for thei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e25a8661e38a7feb14ee852cdd53444d
https://doi.org/10.1016/j.molstruc.2021.131491

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