Zobrazeno 1 - 6 of 6 pro vyhledávání: '"Asmaa G. Safi El-Din"'
1
Novel S-Mercaptotriazolebenzothiazole-Based Derivatives as Antimicrobial Agents: Design, Synthesis, and In Vitro Evaluation
Autor: Ahmed H. Abdelazeem, Alaa M. Alqahtani, Asmaa G. Safi El-Din, Randa Abdou, Ali H. Amin, Hany H. Arab
Publikováno v: Letters in Drug Design & Discovery. 19:925-937
Background: The search for novel antimicrobial agents effective against the emerging resistant pathogenic microorganisms to the currently used drugs is a substantial need. Herein, a novel series of compounds bearing a benzothiazolotriazole scaffold w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::326641201b87577a9739a5be0e42d14c
https://doi.org/10.2174/1570180819666220301154851
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2
Novel benzo[4,5]thiazolo[2,3-C][1,2,4]triazoles: Design, synthesis, anticancer evaluation, kinase profiling and molecular docking study
Autor: Asmaa G. Safi El-Din, Ahmed H. Abdelazeem, Ahmed M. Gouda, Alaa M. Alqahtani, Hany H. Arab
Publikováno v: Journal of Molecular Structure. 1246:131138
In the current study, we report the synthesis and cytotoxic evaluation of a new series of S-benzo[4,5]thiazolo[2,3-c][1,2,4]triazole-based derivatives 8-12. Cytotoxicity of the new compounds was investigated in A549, MCF-7, and Hep3B cancer cell line
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::89d250f657ead5c55c89a02aef00bd8a
https://doi.org/10.1016/j.molstruc.2021.131138
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3
Design, synthesis and anti-inflammatory/analgesic evaluation of novel di-substituted urea derivatives bearing diaryl-1,2,4-triazole with dual COX-2/sEH inhibitory activities
Autor: Samir M. El-Moghazy, Hany H. Arab, Noha H. Amin, Asmaa G. Safi El-Din, Mohammed T. El-Saadi, Ahmed H. Abdelazeem
Publikováno v: Journal of Molecular Structure. 1240:130565
Herein, two novel series of diaryl-1,2,4-triazole hybrid to amide conjugates (5a-e) or urea conjugates (10a-f) have been synthesized followed by in vitro evaluation against cyclooxygenase-2/soluble epoxide hydrolase (COX-2/sEH) enzymes using ELISA en
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c253ce3288b70d6c83bdec8246284d86
https://doi.org/10.1016/j.molstruc.2021.130565
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4
Design, synthesis and analgesic/anti-inflammatory evaluation of novel diarylthiazole and diarylimidazole derivatives towards selective COX-1 inhibitors with better gastric profile
Autor: Hany A. Omar, Asmaa G. Safi El-Din, Ahmed H. Abdelazeem, Samir M. El-Moghazy, Mohammed T. El-Saadi
Publikováno v: Bioorganic & Medicinal Chemistry. 25:665-676
The inhibition of gastric cyclooxygenase 1 (COX-1) enzyme was believed to be the major cause of non-steroidal anti-inflammatory drugs (NSAIDs)-induced gastric ulcer. Recent studies disproved this belief and showed that the gastric tissues vulnerabili
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebf64fbc908ee22c525fcd7cf172bd33
https://doi.org/10.1016/j.bmc.2016.11.037
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5
Discovery of novel urea-diarylpyrazole hybrids as dual COX-2/sEH inhibitors with improved anti-inflammatory activity and highly reduced cardiovascular risks
Autor: Maha M. Abdel-Fattah, Ahmed H. Abdelazeem, Asmaa G. Safi El-Din, Mohammed T. El-Saadi, Samir M. El-Moghazy, Noha H. Amin
Publikováno v: European Journal of Medicinal Chemistry. 205:112662
Herein we describe our efforts to develop novel anti-inflammatory/analgesic agents devoid of known cardiovascular drawbacks. In doing so, two 1,5-diarylpyrazole series of urea linked (9a-f) and amide linked (11a-f) compounds were synthesized and eval
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de04d97515a2f2a1594d5b8e99187fc
https://doi.org/10.1016/j.ejmech.2020.112662
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