Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Asma Tulbah"'
Autor:
Marwa Elfoly, Jumanah Y. Mirza, Ayodele Alaiya, Amal A. Al-Hazzani, Asma Tulbah, Monther Al-Alwan, Hazem Ghebeh
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-16 (2024)
Abstract Background PD-L1 intrinsically promotes tumor progression through multiple mechanisms, which potentially leads to resistance to anti-PD-1/PD-L1 therapies. The intrinsic effect of PD-L1 on breast cancer (BC) cell proliferation has not been fu
Externí odkaz:
https://doaj.org/article/f566893f991f499ea6cf467f7bb0d987
Autor:
Syed S. Islam, Taher Al-Tweigeri, Layla Al-Harbi, Shafat Ujjahan, Maha Al-Mozaini, Asma Tulbah, Abdelilah Aboussekhra
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract Breast cancer (BC) patient who receives chemotherapy for an extended length of time may experience profound repercussions in terms of metastases and clinical outcomes due to the involvement of the epithelial-to-mesenchymal transition (EMT) m
Externí odkaz:
https://doaj.org/article/36a646056f724073be5011d02cb36d13
Autor:
Rong Bu, Abdul K. Siraj, Maha Al-Rasheed, Kaleem Iqbal, Saud Azam, Zeeshan Qadri, Wael Haqawi, Asma Tulbah, Fouad Al-Dayel, Osama Almalik, Khawla S. Al-Kuraya
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Breast cancer (BC) is the most prevalent malignancy among women worldwide with germline pathogenic variants/likely pathogenic variants (PVs/LPVs) in BRCA1/2 accounting for a large portion of hereditary cases. Recently, heterozygous PVs/LPVs
Externí odkaz:
https://doaj.org/article/0488b7354eda4a4ca492a51ccc846bac
Autor:
Abdul K. Siraj, Rong Bu, Sandeep Kumar Parvathareddy, Kaleem Iqbal, Saud Azam, Zeeshan Qadri, Maha Al-Rasheed, Wael Haqawi, Mark Diaz, Ingrid G. Victoria, Ismail A. Al-Badawi, Asma Tulbah, Fouad Al-Dayel, Dahish Ajarim, Khawla S. Al-Kuraya
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-7 (2023)
Abstract The PALB2 gene is a breast cancer (BC) and ovarian cancer (OC) predisposition gene involved in the homologous recombination repair pathway. However, the prevalence and clinicopathological association of PALB2 pathogenic/likely pathogenic (PV
Externí odkaz:
https://doaj.org/article/0c97e2f47b824050854ac2fed92effc0
Autor:
Taher Al-Tweigeri, Noura N. AlRaouji, Asma Tulbah, Maria Arafah, Mouad Aboussekhra, Falah Al-Mohanna, Ahmed Mostafa Gad, Abdelmonneim M. Eldali, Tusneem A. Elhassan, Abdelilah Aboussekhra
Publikováno v:
Breast Cancer Research, Vol 24, Iss 1, Pp 1-15 (2022)
Abstract Background Locally advanced breast cancer (LABC), the most aggressive form of the disease, is a serious threat for women's health worldwide. The AU-rich RNA-binding factor 1 (AUF1) promotes the formation of chemo-resistant breast cancer stem
Externí odkaz:
https://doaj.org/article/fdfaf012f7d645afbcc26f3df30413d9
Autor:
Abdul Khalid Siraj, Tariq Masoodi, Rong Bu, Sandeep Kumar Parvathareddy, Kaleem Iqbal, Saud Azam, Maha Al-Rasheed, Dahish Ajarim, Asma Tulbah, Fouad Al-Dayel, Khawla Sami Al-Kuraya
Publikováno v:
Hereditary Cancer in Clinical Practice, Vol 19, Iss 1, Pp 1-9 (2021)
Abstract Background The data on prevalence and clinical relevance of TP53 germline mutations in early onset Middle-Eastern breast cancer (BC) is limited. Methods We determined TP53 germline mutations in a cohort of 464 early onset BC patients from Sa
Externí odkaz:
https://doaj.org/article/69aadafd781648d29b443baea330bfaf
Autor:
Hazem Ghebeh, Adher Al-Sayed, Riham Eiada, Leilani Cabangon, Dahish Ajarim, Kausar Suleman, Asma Tulbah, Taher Al-Tweigeri
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Therapeutic anti-PD-L1 antibodies are safe as a monotherapy, albeit with minimal efficacy in triple-negative breast cancer (TNBC). This trial aimed to test the safety and efficacy of Durvalumab and Paclitaxel in metastatic TNBC. In this open
Externí odkaz:
https://doaj.org/article/4082da344ce44ce6b8b8a7859e11152b
Autor:
Layla A. Al-Kharashi, Asma Tulbah, Maria Arafah, Abdelmonneim M. Eldali, Taher Al-Tweigeri, Abdelilah Aboussekhra
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BackgroundActive breast cancer-associated fibroblasts (CAFs) play a leading role in breast carcinogenesis through promoting angiogenesis and resistance to therapy. Consequently, these active stromal cells have significant influence on patient outcome
Externí odkaz:
https://doaj.org/article/f60d4db3c00e44c5922321049ef9a011
Autor:
Sandeep Kumar Parvathareddy, Abdul K. Siraj, Ismail A. Al-Badawi, Asma Tulbah, Fouad Al-Dayel, Khawla S. Al-Kuraya
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Ovarian cancer (OC) is one of the most common gynecologic cancer, which has the worst prognosis and highest mortality rate. The lack of curative treatment and the high relapse rate, especially in advanced OC, continues to present a clinical
Externí odkaz:
https://doaj.org/article/4d0abb22ea52428a9864906c7c704522
Autor:
Mysoon M. Al-Ansari, Maher Al-Saif, Maria Arafah, Abdelmonneim M. Eldali, Asma Tulbah, Taher Al-Tweigeri, Abdelhabib Semlali, Khalid S. Khabar, Abdelilah Aboussekhra
Publikováno v:
Breast Cancer Research, Vol 22, Iss 1, Pp 1-12 (2020)
Abstract Background Most breast cancer-associated fibroblasts (CAFs) are active and important cancer-promoting cells, with significant impact on patient prognosis. Therefore, we investigated here the role of the protein kinase ATR in breast stromal f
Externí odkaz:
https://doaj.org/article/3ba1da8a49ab492aadff73a319d53652