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Consequences of Acute or Chronic Methylphenidate Exposure Using Ex Vivo Neurochemistry and In Vivo Electrophysiology in the Prefrontal Cortex and Striatum of Rats

Autor: Mathieu Di Miceli, Asma Derf, Benjamin Gronier

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 15; Pages: 8588

Methylphenidate (MPH) is among the main drugs prescribed to treat patients with attention-deficit and hyperactivity disease (ADHD). MPH blocks both the norepinephrine and dopamine reuptake transporters (NET and DAT, respectively). Our study was aimed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f17e76ec44df445b44ff4bb5be1d98d5

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Inhibitors of Aβ42-induced endoplasmic reticular unfolded protein response (UPRER), in yeast, also rescue yeast cells from Aβ42-mediated apoptosis

Autor: Asma Derf, Sandip B. Bharate, Bhabatosh Chaudhuri, Ramesh Mudududdla

Publikováno v: European Journal of Pharmaceutical Sciences. 128:118-127

Aggregated Aβ peptides which cause amyloid deposits, a characteristic of Alzheimer's disease (AD), activate a stress response in the endoplasmic reticulum (ER), known as the unfolded protein response, UPRER. Nascent UPRER induction helps in reducing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::58a0b73ded58a52b118715de1d1d6add
https://doi.org/10.1016/j.ejps.2018.11.029

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Nonantioxidant Tetramethoxystilbene Abrogates α-Synuclein-Induced Yeast Cell Death but Not That Triggered by the Bax or βA4 Peptide

Autor: Ramesh Mudududdla, Mohd Abdullaha, Damilare Akintade, Bhabatosh Chaudhuri, Sandip B. Bharate, Asma Derf, Ibidapo S. Williams

Publikováno v: ACS Omega

© 2018 American Chemical Society. The overexpression of α-synuclein (α-syn) and its aggregation is the hallmark of Parkinson's disease. The α-syn aggregation results in the formation of Lewy bodies that causes neuronal cell death. Therefore, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f098bc4bf709665d45e283ca9f83ca
https://doi.org/10.1021/acsomega.8b01154

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Aegeline, a natural product from the plant Aegle marmelos, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast

Autor: Bhabatosh Chaudhuri, Asma Derf, Ankita Sharma, Sandip B. Bharate

Publikováno v: Bioorganicmedicinal chemistry letters. 29(3)

Herein, we have identified yeast Sec22p (ySec22p), a SNARE protein essential for endoplasmic reticulum to Golgi trafficking, as a suppressor of Bax-induced yeast apoptosis and corroborated published observations that ySec22p suppresses α-synuclein's

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::427be639400abd6aa9f98a30662100b1
https://pubmed.ncbi.nlm.nih.gov/31281017

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Inhibitors of Aβ42-induced endoplasmic reticular unfolded protein response (UPR

Autor: Asma, Derf, Ramesh, Mudududdla, Sandip B, Bharate, Bhabatosh, Chaudhuri

Publikováno v: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 128

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::42370e981568427268f051760b526882
https://pubmed.ncbi.nlm.nih.gov/30502452

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Radicicol rescues yeast cell death triggered by expression of human α-synuclein and its A53T mutant, but not by human βA4 peptide and proapoptotic protein bax

Autor: Bhabatosh Chaudhuri, Shreyans K. Jain, Asma Derf, Shilpa Amit Verekar, Sunil K. Deshmukh, Sandip B. Bharate

Publikováno v: Bioorganic chemistry. 85

Aggregation/misfolding of α-synuclein and βA4 proteins cause neuronal cell death (NCD) associated with Parkinson's and Alzheimer's disease. It has been suggested that a heat shock protein-90 (Hsp90) inhibitor can prevent NCD by activating the heat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92ff5097b91394f13109ecff86b96503
https://pubmed.ncbi.nlm.nih.gov/30612081

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Corrigendum to 'Aegeline, a natural product from the plant Aegle marmelos, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast' [Bioorg. Med. Chem. Lett. 29 (2019) 454–460]

Autor: Bhabatosh Chaudhuri, Ankita Sharma, Sandip B. Bharate, Asma Derf

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 29:2437-2438

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aa13e6a17cc61c49026cc83980215667
https://doi.org/10.1016/j.bmcl.2019.06.053

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