A simultaneous X-ray diffraction–differential scanning calorimetry study into the phase transitions of mefenamic acid

Autor: Gareth R. Williams, Oxana V. Magdysyuk, Richard Telford, Asma B. M. Buanz, Yuying Pang, Simon Gaisford

Publikováno v: Journal of Applied Crystallography. 52:1264-1270

In this study, the polymorphic transitions of mefenamic acid (MA) were studied by synchrotron X-ray powder diffraction combined with differential scanning calorimetry (XRD-DSC). The initial material was found to be phase-pure form I which, when heate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::67a5991691b7be1167b3d1f40010950a
https://doi.org/10.1107/s1600576719012500

Mechanistic in situ and ex situ studies of phase transformations in molecular co‐crystals

Autor: Dejan-Krešimir Bučar, Asma B. M. Buanz, Dongpeng Yan, Gareth R. Williams, Alexander E. Clout, Timothy J. Prior, Gary N. Parkinson, Yuying Pang, Simon Gaisford, Wing‐Mei Tsui

Publikováno v: Clout, A 2020, ' Mechanistic in situ and ex situ studies of phase transformations in molecular co-crystals ', Chemistry – A European Journal . https://doi.org/10.1002/chem.202002267
Chemistry (Weinheim an Der Bergstrasse, Germany)

Co‐crystallisation is widely explored as a route to improve the physical properties of pharmaceutical active ingredients, but little is known about the fundamental mechanisms of the process. Herein, we apply a hyphenated differential scanning calor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4591f6d65471dc3b719b28f800bd827a
https://www.research.manchester.ac.uk/portal/en/publications/mechanistic-in-situ-and-ex-situ-studies-of-phase-transformations-in-molecular-cocrystals(7e837bf2-ff92-4cd3-842d-11b39543e25d).html

Formation of Highly Metastable β Glycine by Confinement in Inkjet Printed Droplets

Autor: Asma B. M. Buanz, Simon Gaisford

Publikováno v: Crystal Growth & Design. 17:1245-1250

Inkjet printing was used to deposit picoliter droplets of aqueous glycine solution onto glass or aluminum substrates and it was found that the volume constraint on crystal growth resulted in formation of the highly metastable β form. When the drople

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::670fe22f0fc81b071fea648172baf0ad
https://doi.org/10.1021/acs.cgd.6b01633

Amorphous Formulation and in Vitro Performance Testing of Instantly Disintegrating Buccal Tablets for the Emergency Delivery of Naloxone

Autor: Ben Forbes, Elizabeth Allen, James Rickard, Shagufta Ahmed, Paul G. Royall, Christopher Holt, Abdulmalik Alqurshi, Zahrae Kumar, Rebecca Stansfield, David Taylor, John Strang, Verity Sandhu, Asma B. M. Buanz, Rebecca McDonald, Peter Cameron

Publikováno v: Alqurshi, A, Kumar, Z, McDonald, R, Strang, J, Buanz, A, Ahmed, S, Allen, E, Cameron, P, Rickard, J A, Sandhu, V, Holt, C, Stansfield, R, Taylor, D, Forbes, B & Royall, P G 2016, ' Amorphous Formulation and in Vitro Performance Testing of Instantly Disintegrating Buccal Tablets for the Emergency Delivery of Naloxone ', Molecular Pharmaceutics, vol. 13, no. 5, pp. 1688-1698 . https://doi.org/10.1021/acs.molpharmaceut.6b00096

The aim of this study was to develop a freeze-dried buccal tablet for the rapid delivery of naloxone in opioid overdose. The tablet composition was optimized to produce an amorphous matrix, which was confirmed by the absence of peaks associated with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed1e32ac657db39ec992acbe2ce1a89e
https://doi.org/10.1021/acs.molpharmaceut.6b00096

Polymorphic Phase Transitions in Carbamazepine and 10,11-Dihydrocarbamazepine

Autor: Alexander E, Clout, Asma B M, Buanz, Simon, Gaisford, Gareth R, Williams

Publikováno v: Chemistry (Weinheim an Der Bergstrasse, Germany)

Temperature‐induced phase transitions in carbamazepine (CBZ) and 10,11‐dihydrocarbamazepine (DHC) were studied by simultaneous differential scanning calorimetry–X‐ray diffraction in this work. The transitions generally involve a transitional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cc059ebf154597a8d83089af4e64b2b5
https://pubmed.ncbi.nlm.nih.gov/29979477