Enhanced Delivery of Oncolytic Adenovirus by Neural Stem Cells for Treatment of Metastatic Ovarian Cancer

Autor: Rachael Mooney, Asma Abdul Majid, Jennifer Batalla-Covello, Diana Machado, Xueli Liu, Joanna Gonzaga, Revathiswari Tirughana, Mohamed Hammad, Maciej S. Lesniak, David T. Curiel, Karen S. Aboody

Publikováno v: Molecular Therapy: Oncolytics, Vol 12, Iss , Pp 79-92 (2019)

Oncolytic virotherapy is a promising approach for treating recurrent and/or drug-resistant ovarian cancer. However, its successful application in the clinic has been hampered by rapid immune-mediated clearance or neutralization of the virus, which re

Externí odkaz: https://doaj.org/article/640fdbac5c2342d1857ec93f5bfc628b

Bcl-2 Overexpression Improves Survival and Efficacy of Neural Stem Cell-Mediated Enzyme Prodrug Therapy

Autor: Rachael Mooney, Asma Abdul Majid, Daniel Mota, Adam He, Soraya Aramburo, Linda Flores, Jennifer Covello-Batalla, Diana Machado, Joanna Gonzaga, Karen S. Aboody

Publikováno v: Stem Cells International, Vol 2018 (2018)

Tumor-tropic neural stem cells (NSCs) can be engineered to localize gene therapies to invasive brain tumors. However, like other stem cell-based therapies, survival of therapeutic NSCs after transplantation is currently suboptimal. One approach to pr

Externí odkaz: https://doaj.org/article/dd1bd1411a5148d684d28764d22dc201

Neural Stem Cells Improve the Delivery of Oncolytic Chimeric Orthopoxvirus in a Metastatic Ovarian Cancer Model

Autor: Zheng Liu, Karen S. Aboody, Connor Burke, Min Li, Yuman Fong, Jianming Lu, Yate-Ching Yuan, Rachael Mooney, Jennifer Batalla-Covello, Yvonne R. Cornejo, Asma Abdul Majid, Mohamed Hammad, Thanh H. Dellinger, Nanhai G. Chen

Publikováno v: Molecular Therapy: Oncolytics, Vol 18, Iss, Pp 326-334 (2020)
Molecular Therapy Oncolytics

Oncolytic virotherapy represents a promising approach for treating recurrent and/or drug-resistant ovarian cancer. However, its successful application in the clinic has been hampered by rapid immune-mediated clearance, which reduces viral delivery to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32e6c103c81c7b46524dfac2ab6d2458
https://doi.org/10.1016/j.omto.2020.07.002

Concise Review: Neural Stem Cell-Mediated Targeted Cancer Therapies

Autor: Asma Abdul Majid, Jennifer Batalla-Covello, Rachael Mooney, Karen S. Aboody, Mohamed Hammad

Publikováno v: Stem Cells Translational Medicine

Cancer is one of the leading causes of morbidity and mortality worldwide, with 1,688,780 new cancer cases and 600,920 cancer deaths projected to occur in 2017 in the U.S. alone. Conventional cancer treatments including surgical, chemo-, and radiation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f26a524fc99f17c4d2b7b41561c44d62
https://doi.org/10.1002/sctm.18-0003

Enhanced Delivery of Oncolytic Adenovirus by Neural Stem Cells for Treatment of Metastatic Ovarian Cancer

Autor: Joanna Gonzaga, David T. Curiel, Jennifer Batalla-Covello, Karen S. Aboody, Asma Abdul Majid, Mohamed Hammad, Rachael Mooney, Maciej S. Lesniak, Revathiswari Tirughana, Xueli Liu, Thanh H. Dellinger, Diana Machado

Publikováno v: Molecular Therapy: Oncolytics, Vol 12, Iss, Pp 79-92 (2019)
Molecular Therapy: Oncolytics, Vol 17, Iss, Pp 508-(2020)
Molecular Therapy Oncolytics

Oncolytic virotherapy is a promising approach for treating recurrent and/or drug-resistant ovarian cancer. However, its successful application in the clinic has been hampered by rapid immune-mediated clearance or neutralization of the virus, which re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::342c4d6e4c1bf851ca4a58ff5ec0cab1
https://doi.org/10.1016/j.omto.2020.05.005