Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Aslihan Bastem"'
Autor:
Adam E. Hall, Sebastian Öther-Gee Pohl, Patrizia Cammareri, Stuart Aitken, Nicholas T. Younger, Michela Raponi, Caroline V. Billard, Alfonso Bolado Carrancio, Aslihan Bastem, Paz Freile, Fiona Haward, Ian R. Adams, Javier F. Caceres, Paula Preyzner, Alex von Kriegsheim, Malcolm G. Dunlop, Farhat V. Din, Kevin B. Myant
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
The influence of mRNA splicing on colon cancer development and progression is unclear. In this study, the authors demonstrate that the SRSF1 splicing factor is essential to sustain the stem cell phenotype of WNT-activated colorectal cancers.
Externí odkaz:
https://doaj.org/article/b084ea4f47254a91b5543e19fe89996c
Autor:
Adam E. Hall, Sebastian Öther-Gee Pohl, Patrizia Cammareri, Stuart Aitken, Nicholas T. Younger, Michela Raponi, Caroline V. Billard, Alfonso Bolado Carrancio, Aslihan Bastem, Paz Freile, Fiona Haward, Ian R. Adams, Javier F. Caceres, Paula Preyzner, Alex von Kriegsheim, Malcolm G. Dunlop, Farhat V. Din, Kevin B. Myant
Publikováno v:
Nature Communications
Hall, A E, Pohl, S Ö, Cammareri, P, Aitken, S, Younger, N T, Raponi, M, Billard, C V, Carrancio, A B, Bastem, A, Freile, P, Haward, F, Adams, I R, Caceres, J F, Preyzner, P, Von Kriegsheim, A, Dunlop, M G, Din, F V & Myant, K B 2022, ' RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer ', Nature Communications, vol. 13, no. 1, 2791 . https://doi.org/10.1038/s41467-022-30489-z
Hall, A E, Pohl, S Ö, Cammareri, P, Aitken, S, Younger, N T, Raponi, M, Billard, C V, Carrancio, A B, Bastem, A, Freile, P, Haward, F, Adams, I R, Caceres, J F, Preyzner, P, Von Kriegsheim, A, Dunlop, M G, Din, F V & Myant, K B 2022, ' RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer ', Nature Communications, vol. 13, no. 1, 2791 . https://doi.org/10.1038/s41467-022-30489-z
Tumour cell plasticity is a major barrier to the efficacy of targeted cancer therapies but the mechanisms that mediate it are poorly understood. Here, we identify dysregulated RNA splicing as a key driver of tumour cell dedifferentiation in colorecta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec6df06c75a34c01c4023ea8ad47353d