Oncogenic composite mutations can be predicted by co‐mutations and their chromosomal location

Autor: Asli Küçükosmanoglu, Carolien L. van derBorden, Lisanne E. A. deBoer, Roel Verhaak, David Noske, Tom Wurdinger, Teodora Radonic, Bart A. Westerman

Publikováno v: Molecular Oncology, Vol 18, Iss 10, Pp 2407-2422 (2024)

Genetic heterogeneity in tumors can show a remarkable selectivity when two or more independent genetic events occur in the same gene. This phenomenon, called composite mutation, points toward a selective pressure, which frequently causes therapy resi

Externí odkaz: https://doaj.org/article/2f535455fe3d438d87cea860c9cbc6cf

Abstract 6312: The adverse events atlas, towards a strategy to predict synergistic adverse events of combination therapies

Autor: Asli Kucukosmanoglu, Silvia Scoarta, Thomas Wijnands, George Kanev, Bart Westerman, Bert Kiewit, David Noske, Tom Wurdinger

Publikováno v: Cancer Research. 82:6312-6312

The current gold-standard of estimating adverse events of a drug are clinical trials. However, these trials fail to represent real-life practice where patients have additional diseases (comorbidities) and commonly use numerous drugs when entering the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::697803d8d9c89679e77d30b98ace248f
https://doi.org/10.1158/1538-7445.am2022-6312

Loss of p53 suppresses replication-stress-induced DNA breakage in G1/S checkpoint deficient cells

Autor: Simone Hermsen, Josephine C. Dorsman, Elly Delzenne-Goette, Asli Kucukosmanoglu, Hein te Riele, Wietske Pieters, Eva Petermann, Marleen Dekker, Tanja van Harn, Floris Foijer, Bente Benedict

Publikováno v: eLife, Vol 7 (2018)
eLife
eLife, 7:37868. ELIFE SCIENCES PUBLICATIONS LTD
eLife, 7. eLife Sciences Publications Limited
Benedict, B, van Harn, T, Dekker, M, Hermsen, S, Kucukosmanoglu, A, Pieters, W, Delzenne-Goette, E, Dorsman, J C, Petermann, E, Foijer, F & te Riele, H 2018, ' Loss of p53 suppresses replication-stress-induced DNA breakage in G1/S checkpoint deficient cells ', eLife, vol. 7 . https://doi.org/10.7554/eLife.37868

In cancer cells, loss of G1/S control is often accompanied by p53 pathway inactivation, the latter usually rationalized as a necessity for suppressing cell cycle arrest and apoptosis. However, we found an unanticipated effect of p53 loss in mouse and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd6ee649aa27bdd349366ce26274b21
https://elifesciences.org/articles/37868

Radiosensitivity is an acquired vulnerability of PARPi-resistant BRCA1-deficient tumors

Autor: Sven Rottenberg, Yike Huang, Natalie Proost, Stefano Annunziato, Peter Bouwman, Marieke van de Ven, Gerben R. Borst, Ariena Kersbergen, Alessia Gasparini, Asli Kucukosmanoglu, Wendy Sol, Marco Barazas, Jos Jonkers

The homologous recombination (HR) defect in BRCA1-associated cancers can be therapeutically exploited by the treatment with DNA-damaging agents and poly (ADP-ribose) polymerase (PARP) inhibitors. We and others previously reported that BRCA1-deficient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52d74831d78532fd8c632aae6fa2f821
https://doi.org/10.1101/370577

ABCC6 prevents ectopic mineralization seen in pseudoxanthoma elasticum by inducing cellular nucleotide release

Autor: Piet Borst, Koen van de Wetering, Jon A. Otero, Sunny Sapthu, Marcel de Haas, Asli Kucukosmanoglu, Theo G. M. F. Gorgels, Robert S. Jansen, Arthur A.B. Bergen, Ilse E. M. Hegman

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 110(50), 20206-20211. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 110, 20206-20211. National Academy of Sciences
Jansen, R S, Küçükosmanoǧlu, A, De Haas, M, Sapthu, S, Otero, J A, Hegman, I E M, Bergen, A A B, Gorgels, T G M F, Borst, P & Van De Wetering, K 2013, ' ABCC6 prevents ectopic mineralization seen in pseudoxanthoma elasticum by inducing cellular nucleotide release ', Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 50, pp. 20206-20211 . https://doi.org/10.1073/pnas.1319582110

Pseudoxanthoma elasticum (PXE) is an autosomal recessive disease characterized by progressive ectopic mineralization of the skin, eyes, and arteries, for which no effective treatment exists. PXE is caused by inactivating mutations in the gene encodin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b31be1682a2a3991d0f478d83613a89
https://doi.org/10.1073/pnas.1319582110