Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Asli F. Ceylan-Isik"'
Publikováno v:
Journal of Molecular and Cellular Cardiology. 74:76-87
Lipopolysaccharide (LPS), an essential component of the outer membrane of Gram-negative bacteria, plays a pivotal role in myocardial anomalies in sepsis. Recent evidence has depicted a role of Akt in LPS-induced cardiac sequelae although little infor
Publikováno v:
Toxicology Letters. 206:130-138
Sex difference in cardiac contractile function exists which may contribute to the different prevalence in cardiovascular diseases between genders. However, the precise mechanisms of action behind sex difference in cardiac function are still elusive.
Publikováno v:
Basic Research in Cardiology. 106:1173-1191
Aging is often accompanied with geometric and functional changes in the heart, although the underlying mechanisms remain unclear. Recent evidence has described a potential role of Akt and autophagy in aging-associated organ deterioration. This study
Publikováno v:
Current Diabetes Reviews. 4:320-328
Cardiovascular diseases, the number one causes of death worldwide, are responsible for the majority of the increased morbidity and mortality seen in patients with diabetes mellitus. Useful therapies for diabetes include lifestyle modification and dru
Publikováno v:
Rejuvenation Research. 11:725-733
Circulating insulin-like growth factor-1 (IGF-1) levels are linked to cardiac performance and lifespan. However, the role of IGF-1 levels in aging-associated cardiac dysfunction has not been defined. This study was designed to evaluate the impact of
Publikováno v:
Journal of Applied Physiology. 100:1638-1646
Evidence suggests a sex difference in intrinsic physiological and diabetic myocardial contractile function related to antioxidant properties of female ovarian hormones. This study was designed to examine the effect of cardiac overexpression of antiox
Autor:
Shi-Yan Li, Jamie R. Privratsky, Cindy X. Fang, Jun Ren, Loren E. Wold, Xiaoping Yang, Nair Sreejayan, Asli F. Ceylan-Isik
Publikováno v:
Free Radical Biology and Medicine. 40:1419-1429
Diabetic cardiomyopathy contributes to high morbidity and mortality in diabetic populations. It is manifested by compromised ventricular contraction and prolonged relaxation attributable to multiple causative factors including oxidative stress. This
Publikováno v:
Journal of Applied Physiology. 100:150-156
Diabetic cardiomyopathy is characterized by cardiac dysfunction. This study was designed to examine the effect of benfotiamine, a lipophilic derivative of thiamine, on streptozotocin (STZ)-induced cardiac contractile dysfunction in mouse cardiomyocyt
Publikováno v:
Acta Pharmacologica Sinica. 26:908-917
Cardiovascular disease is the most common cause of death in the diabetic population and is currently one of the leading causes of death in the United States and other industrialized countries. The health care expenses associated with cardiovascular d
Autor:
Min Du, Gabriele E. Mayer, Nair Sreejayan, Shi-Yan Li, Asli F. Ceylan-Isik, Karissa H. LaCour, Jun Ren, Xiaoping Yang, Cindy X. Fang, Christopher J. Wilbert, E. Kurt Dolence
Publikováno v:
Aging Cell. 4:57-64
Evidence suggests that aging, per se, is a major risk factor for cardiac dysfunction. Oxidative modification of cardiac proteins by non-enzymatic glycation, i.e. advanced glycation endproducts (AGEs), has been implicated as a causal factor in the agi