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Synthesis and SAR studies of benzimidazolone derivatives as histamine H3-receptor antagonists.

Autor: Zeng Q; Merck Research Laboratories, 126 E. Lincoln Avenue, Rahway, NJ 07065, USA., Rosenblum SB, Yang Z, Jiang Y, McCormick KD, Aslanian RG, Duguma L, Kozlowski JA, Shih NY, Hey JA, West RE Jr, Korfmacher WA, Berlin M, Boyce CW

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2013 Nov 01; Vol. 23 (21), pp. 6001-3. Date of Electronic Publication: 2013 Aug 13.

Discovery of oral and inhaled PDE4 inhibitors.

Autor: Ting PC; Department of Chemical Research, Merck Research Laboratories, 126 E. Lincoln Ave., Rahway, NJ 07065, USA. Electronic address: pauline.ting@merck.com., Lee JF, Kuang R, Cao J, Gu D, Huang Y, Liu Z, Aslanian RG, Feng KI, Prelusky D, Lamca J, House A, Phillips JE, Wang P, Wu P, Lundell D, Chapman RW, Celly CS

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2013 Oct 15; Vol. 23 (20), pp. 5528-32. Date of Electronic Publication: 2013 Aug 21.

The optimization of pyridazinone series of glucan synthase inhibitors.

Autor: Kuang R; Department of Chemical Research, Merck Research Laboratories, 126 E. Lincoln Ave., Rahway, NJ 07065, USA. rongze.kuang@merck.com, Wu H, Ting PC, Aslanian RG, Cao J, Kim DW, Lee JF, Schwerdt J, Zhou G, Herr RJ, Zych AJ, Yang J, Lam SQ, Jenkins DM, Sakwa SA, Wainhaus S, Black TA, Cacciapuoti A, McNicholas PM, Xu Y, Walker SS

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2012 Aug 15; Vol. 22 (16), pp. 5268-71. Date of Electronic Publication: 2012 Jul 04.

Discovery of a potent thiadiazole class of histamine h3 receptor antagonist for the treatment of diabetes.

Autor: Rao AU; Department of Medicinal Chemistry and Cardiovascular/Metabolic Disease, Merck Research Laboratories , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Shao N; Department of Medicinal Chemistry and Cardiovascular/Metabolic Disease, Merck Research Laboratories , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Aslanian RG; Department of Medicinal Chemistry and Cardiovascular/Metabolic Disease, Merck Research Laboratories , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Chan TY; Department of Medicinal Chemistry and Cardiovascular/Metabolic Disease, Merck Research Laboratories , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Degrado SJ; Department of Medicinal Chemistry and Cardiovascular/Metabolic Disease, Merck Research Laboratories , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Wang L; Department of Medicinal Chemistry and Cardiovascular/Metabolic Disease, Merck Research Laboratories , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., McKittrick B; Department of Medicinal Chemistry and Cardiovascular/Metabolic Disease, Merck Research Laboratories , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Senior M; Department of Medicinal Chemistry and Cardiovascular/Metabolic Disease, Merck Research Laboratories , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., West RE Jr; Department of Medicinal Chemistry and Cardiovascular/Metabolic Disease, Merck Research Laboratories , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Williams SM; Department of Medicinal Chemistry and Cardiovascular/Metabolic Disease, Merck Research Laboratories , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Wu RL; Department of Medicinal Chemistry and Cardiovascular/Metabolic Disease, Merck Research Laboratories , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Hwa J; Department of Medicinal Chemistry and Cardiovascular/Metabolic Disease, Merck Research Laboratories , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Patel B; Department of Medicinal Chemistry and Cardiovascular/Metabolic Disease, Merck Research Laboratories , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Zheng S; Department of Medicinal Chemistry and Cardiovascular/Metabolic Disease, Merck Research Laboratories , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Sondey C; Department of Medicinal Chemistry and Cardiovascular/Metabolic Disease, Merck Research Laboratories , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Palani A; Department of Medicinal Chemistry and Cardiovascular/Metabolic Disease, Merck Research Laboratories , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2011 Nov 21; Vol. 3 (3), pp. 198-202. Date of Electronic Publication: 2011 Nov 21 (Print Publication: 2012).