Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Aslamuzzaman, Kazi"'
Publikováno v:
iScience, Vol 26, Iss 3, Pp 106082- (2023)
Summary: KRAS mutations are prevalent in pancreatic and lung cancers, but not all mutant (mt) KRAS tumors are addicted to mt KRAS. Here, we discovered a 30-gene transcriptome signature “KDS30” that encodes a novel EGFR/ERBB2-driven signaling netw
Externí odkaz:
https://doaj.org/article/d36dcf12c3fb495b80f4008e28cd2572
Autor:
Aslamuzzaman Kazi, Shengyan Xiang, Hua Yang, Daniel Delitto, José Trevino, Rays H. Y. Jiang, Muhammad Ayaz, Harshani R. Lawrence, Perry Kennedy, Saïd M. Sebti
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Direct targeting of mutant KRas is challenging and alternative approaches are needed. Here they show glycogen synthase kinase 3 (GSK3) to be required for the growth and survival of human mutant KRas-dependent tumors but dispensable for mutant KRas-in
Externí odkaz:
https://doaj.org/article/e4dd4e549d124d48b1ca42f85db738ff
Autor:
Marco L. Davila, Said M. Sebti, Xuefeng Wang, Aslamuzzaman Kazi, Bin Yu, Bishwas Shrestha, Estelle V. Cervantes, Nolan J. Beatty, Kristen Spitler, Sae Bom Lee, Dylan Morrissey, Maria L. Cabral, Hiroshi Kotani, Gongbo Li, Justin C. Boucher
An obstacle to the development of chimeric antigen receptor (CAR) T cells is the limited understanding of CAR T-cell biology and the mechanisms behind their antitumor activity. We and others have shown that CARs with a CD28 costimulatory domain drive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::480f3f1f552353ae85ba30f8549f9333
https://doi.org/10.1158/2326-6066.c.6550362
https://doi.org/10.1158/2326-6066.c.6550362
Autor:
Marco L. Davila, Said M. Sebti, Xuefeng Wang, Aslamuzzaman Kazi, Bin Yu, Bishwas Shrestha, Estelle V. Cervantes, Nolan J. Beatty, Kristen Spitler, Sae Bom Lee, Dylan Morrissey, Maria L. Cabral, Hiroshi Kotani, Gongbo Li, Justin C. Boucher
Supplemental Tables and Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::435c5667a376d910358801b37318b724
https://doi.org/10.1158/2326-6066.22543680.v1
https://doi.org/10.1158/2326-6066.22543680.v1
Autor:
Saïd M. Sebti, José Trevino, John Koomen, Eric A. Welsh, Mokenge Malafa, Jason B. Fleming, Patrick Underwood, Kazim Husain, Terence M. Williams, Bin Fang, Francisca Beato, Hua Yang, Rajanikanth Vangipurapu, Shengyan Xiang, Liwei Chen, Aslamuzzaman Kazi
Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f3c5c7bb40829ed9e2c0a6092ad296a
https://doi.org/10.1158/1078-0432.22480673.v1
https://doi.org/10.1158/1078-0432.22480673.v1
Autor:
Saïd M. Sebti, José Trevino, John Koomen, Eric A. Welsh, Mokenge Malafa, Jason B. Fleming, Patrick Underwood, Kazim Husain, Terence M. Williams, Bin Fang, Francisca Beato, Hua Yang, Rajanikanth Vangipurapu, Shengyan Xiang, Liwei Chen, Aslamuzzaman Kazi
Purpose:Among human cancers that harbor mutant (mt) KRas, some, but not all, are dependent on mt KRas. However, little is known about what drives KRas dependency.Experimental Design:Global phosphoproteomics, screening of a chemical library of FDA dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5522e5fa9b7383df56badf8e1b5b2172
https://doi.org/10.1158/1078-0432.c.6530501
https://doi.org/10.1158/1078-0432.c.6530501
Autor:
Saïd M. Sebti, José Trevino, John Koomen, Eric A. Welsh, Mokenge Malafa, Jason B. Fleming, Patrick Underwood, Kazim Husain, Terence M. Williams, Bin Fang, Francisca Beato, Hua Yang, Rajanikanth Vangipurapu, Shengyan Xiang, Liwei Chen, Aslamuzzaman Kazi
Supplementary Figures Legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a5d61663c85de4f79cf80423cc27a7c
https://doi.org/10.1158/1078-0432.22480658.v1
https://doi.org/10.1158/1078-0432.22480658.v1
Autor:
Said M. Sebti, Andrew D. Hamilton, Jose G. Trevino, Jason B. Fleming, Patrick W. Underwood, Andrea Delitto, Michael P. Kim, Ya'an Kang, Francisca Beato, Harshani R. Lawrence, Christopher Cummings, Steven Fletcher, Muhammad Ayaz, Perry Kennedy, Liwei Chen, Hua Yang, Shengyan Xiang, Aslamuzzaman Kazi
Purpose:Mutant KRAS is a major driver of pancreatic oncogenesis and therapy resistance, yet KRAS inhibitors are lacking in the clinic. KRAS requires farnesylation for membrane localization and cancer-causing activity prompting the development of farn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22fe9b119d20d64790f763c5df4d19fc
https://doi.org/10.1158/1078-0432.c.6528320.v1
https://doi.org/10.1158/1078-0432.c.6528320.v1
Autor:
Terence M. Williams, Shengyan Xiang, Francisca Beato, Hua Yang, Jose G. Trevino, Jason B. Fleming, Bin Fang, Said M. Sebti, Kazim Husain, Aslamuzzaman Kazi, Mokenge P. Malafa, Liwei Chen, rajanikanth vangipurapu, John M. Koomen, Eric A. Welsh, Patrick W. Underwood
Publikováno v:
Clin Cancer Res
Purpose: Among human cancers that harbor mutant (mt) KRas, some, but not all, are dependent on mt KRas. However, little is known about what drives KRas dependency. Experimental Design: Global phosphoproteomics, screening of a chemical library of FDA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95c4aa6bdce35bb73eb6802d9949d267
https://doi.org/10.1158/1078-0432.ccr-20-4781
https://doi.org/10.1158/1078-0432.ccr-20-4781
Publikováno v:
J Biol Chem
In human cancer cells that harbor mutant KRAS and WT p53 (p53), KRAS contributes to the maintenance of low p53 levels. Moreover, KRAS depletion stabilizes and reactivates p53 and thereby inhibits malignant transformation. However, the mechanism by wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e69855302ac15180fba539257bab5907
https://doi.org/10.1074/jbc.ra119.011930
https://doi.org/10.1074/jbc.ra119.011930