Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Aslam M. Ansari"'
Autor:
Aslam M. Ansari, Sydney O. Ugwu
Publikováno v:
Synthetic Communications. 38:2330-2340
A general and efficient synthetic route to α-amino acids by alkylation of the sodium salt of Schiff base ester 1 has been described previously. The α-substituted ethyl glycinates 4a–g are prepared in excellent yield by a two-step sequence involvi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28eae332aea2293e18347c330a63d9ca
https://doi.org/10.1080/00397910802138611
https://doi.org/10.1080/00397910802138611
Autor:
Frank Y. Xie, Puthupparampil V. Scaria, Aslam M. Ansari, Barry T. Rouse, Bumseok Kim, Raymond M. Schiffelers, Partha S. Biswas, Jun Xu, Patrick Y. Lu, Qingquan Tang, Martin C. Woodle
Publikováno v:
The American Journal of Pathology. 165:2177-2185
Ocular neovascularization often results in vision impairment. Frequently vascular endothelial cell growth factors (VEGFs) are mainly responsible for the pathological neovascularization as in the case in neovascularization induced by CpG oligodeoxynuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::700226166fc76dba2a37bd65d5c87f34
https://doi.org/10.1016/s0002-9440(10)63267-1
https://doi.org/10.1016/s0002-9440(10)63267-1
Autor:
Aslam M. Ansari, Sydney O. Ugwu
Publikováno v:
ChemInform. 39
A general and efficient synthetic route to α-amino acids by alkylation of the sodium salt of Schiff base ester 1 has been described previously. The α-substituted ethyl glycinates 4a–g are prepared in excellent yield by a two-step sequence involvi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::493209b5003f72390f1988eecc0a4030
https://doi.org/10.1002/chin.200849047
https://doi.org/10.1002/chin.200849047
Autor:
Aslam M. Ansari, Grietje Molema, Marcel H.A.M. Fens, Qin Zhou, Puthupparampil V. Scaria, Martin C. Woodle, A. J. Mixson, Raymond M. Schiffelers, Gert Storm, Quingquan Tang, Jun Xu, Patrick Y. Lu
Publikováno v:
Journal of Controlled Release, 109(1-3), 5-14. Elsevier Bedrijfsinformatie b.v.
The recently developed siRNA oligonucleotides are an attractive alternative to antisense as a therapeutic modality because of their robust, gene selective silencing of drug target protein expression. To achieve therapeutic success, however, several h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28f4a3274348382b75a33ceedb2c6932
https://research.rug.nl/en/publications/bc832285-6a43-4130-98c0-de8a4f460118
https://research.rug.nl/en/publications/bc832285-6a43-4130-98c0-de8a4f460118
Autor:
J. Cymerman Craig, Aslam M. Ansari
Publikováno v:
Synthesis. 1995:147-149
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8091e9d554c67ab3f16e4ba88e229d08
https://doi.org/10.1055/s-1995-3886
https://doi.org/10.1055/s-1995-3886
Autor:
Aslam M. Ansari, J. Cymerman Craiga
Publikováno v:
Chirality. 5:188-190
Evidence is accumulating that 7-chloro-4-[4-diethylamino-1-methylbutyl] amino quinoline (chloroquine) displays considerable stereoselectivity in its metabolism, pharmacokinetics, macromolecular interactions, and biological activity. The availability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8aed6e446be41f311afc5d38018da894
https://doi.org/10.1002/chir.530050315
https://doi.org/10.1002/chir.530050315
Autor:
Qin Zhou, Raymond M. Schiffelers, Martin C. Woodle, Aslam M. Ansari, Gert Storm, Puthupparampil V. Scaria
Publikováno v:
Molecular Therapy. 9:S316-S317
Gene therapy, in principle, can be applicable to the management and cure of a variety of diseases, but efficient and targeted delivery of the therapeutic gene to the disease site has been a formidable challenge. Local delivery of genes has some limit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23193763560bfeac82429c5d25bd1c57
https://doi.org/10.1016/j.ymthe.2004.06.735
https://doi.org/10.1016/j.ymthe.2004.06.735
Metabolites of chloroquine: some observations on desethylchloroquine and N-acetyldesethylchloroquine
Autor:
Aslam M. Ansari, J. Cymerman Craig
Publikováno v:
Journal of pharmaceutical sciences. 83(7)
The major metabolite of chloroquine, (+)‐desethylchlo‐roquine, produced by stereoselective N‐dealkylation of the drug, was obtained in 81.5% enantiomeric purity by resolution of racemic desethylchloroquine using an atropisomeric resolving agent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::688571033b2dcee6ad5f79d34133ff5e
https://pubmed.ncbi.nlm.nih.gov/7965661
https://pubmed.ncbi.nlm.nih.gov/7965661
Autor:
Raymond M. Schiffelers, Puthupparampil V. Scaria, Martin C. Woodle, Qin Zhou, Aslam M. Ansari
Publikováno v:
Molecular Therapy. 11:S124
Recent advances in the nucleic acid delivery technology have renewed interest in gene therapy. These advances can benefit not only gene therapy but also nucleic acid therapeutic approaches based on RNA interference, antisense etc. To realize the full
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc9b273c65bdaccad9e6066f033d36a3
https://doi.org/10.1016/j.ymthe.2005.06.321
https://doi.org/10.1016/j.ymthe.2005.06.321
Autor:
Qingquan Tang, Qin Zhou, Grietje Molema, Gert Storm, Jun Xu, Aslam M. Ansari, Patrick Y. Lu, Raymond M. Schiffelers, Puthupparampil V. Scaria, Martin C. Woodle
Publikováno v:
Scopus-Elsevier
Nucleic Acids Research, 32(19):149. Oxford University Press
Nucleic Acids Research, 32(19):149. Oxford University Press
Potent sequence selective gene inhibition by siRNA 'targeted' therapeutics promises the ultimate level of specificity, but siRNA therapeutics is hindered by poor intracellular uptake, limited blood stability and non-specific immune stimulation. To ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce03e93380290f9ee45c1656e12f6a2e
https://doi.org/10.1093/nar/gnh140
https://doi.org/10.1093/nar/gnh140