Zobrazeno 1 - 10
of 677
pro vyhledávání: '"Asla Pitkänen"'
Autor:
Natallie Kajevu, Anssi Lipponen, Pedro Andrade, Ivette Bañuelos, Noora Puhakka, Elina Hämäläinen, Teemu Natunen, Mikko Hiltunen, Asla Pitkänen
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 14049 (2023)
We tested a hypothesis that in silico-discovered compounds targeting traumatic brain injury (TBI)-induced transcriptomics dysregulations will mitigate TBI-induced molecular pathology and augment the effect of co-administered antiseizure treatment, th
Externí odkaz:
https://doaj.org/article/1f3bc2149fe249bdb536c8bf79bb03a8
Autor:
Jenni Karttunen, Mette Heiskanen, Tiina Joki, Anu Hyysalo, Vicente Navarro-Ferrandis, Susanna Miettinen, Susanna Narkilahti, Asla Pitkänen
Publikováno v:
European Journal of Cell Biology, Vol 101, Iss 4, Pp 151270- (2022)
Background: Extracellular vesicles (EVs) secreted by neuronal cells in vitro have promising therapeutic potential for brain diseases. Optimization of cell culture conditions and methodologies for high-yield isolation of EVs for preclinical and clinic
Externí odkaz:
https://doaj.org/article/e8e6d12614ea463580a691e3ae3548f2
Autor:
Anssi Lipponen, Natallie Kajevu, Teemu Natunen, Robert Ciszek, Noora Puhakka, Mikko Hiltunen, Asla Pitkänen
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 4116 (2023)
Analysis platforms to predict drug-induced seizure liability at an early phase of drug development would improve safety and reduce attrition and the high cost of drug development. We hypothesized that a drug-induced in vitro transcriptomics signature
Externí odkaz:
https://doaj.org/article/46ba25784dc24975adec02344f432ac5
Autor:
Mette Heiskanen, Shalini Das Gupta, James D. Mills, Erwin A. van Vliet, Eppu Manninen, Robert Ciszek, Pedro Andrade, Noora Puhakka, Eleonora Aronica, Asla Pitkänen
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2823 (2023)
Traumatic brain injury (TBI) causes 10–20% of structural epilepsies and 5% of all epilepsies. The lack of prognostic biomarkers for post-traumatic epilepsy (PTE) is a major obstacle to the development of anti-epileptogenic treatments. Previous stud
Externí odkaz:
https://doaj.org/article/7cb1f8cc01744e48a0dd32c913752564
Autor:
Riccardo De Feo, Elina Hämäläinen, Eppu Manninen, Riikka Immonen, Juan Miguel Valverde, Xavier Ekolle Ndode-Ekane, Olli Gröhn, Asla Pitkänen, Jussi Tohka
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
Registration-based methods are commonly used in the automatic segmentation of magnetic resonance (MR) brain images. However, these methods are not robust to the presence of gross pathologies that can alter the brain anatomy and affect the alignment o
Externí odkaz:
https://doaj.org/article/c850e16bb8b54a38ab7a0292a30b4aec
Autor:
Mette Heiskanen, Olli Jääskeläinen, Eppu Manninen, Shalini Das Gupta, Pedro Andrade, Robert Ciszek, Olli Gröhn, Sanna-Kaisa Herukka, Noora Puhakka, Asla Pitkänen
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 15208 (2022)
Plasma neurofilament light chain (NF-L) levels were assessed as a diagnostic biomarker for traumatic brain injury (TBI) and as a prognostic biomarker for somatomotor recovery, cognitive decline, and epileptogenesis. Rats with severe TBI induced by la
Externí odkaz:
https://doaj.org/article/49991ee49d01431aad7523ce87096785
Autor:
Eppu Manninen, Karthik Chary, Riccardo De Feo, Elina Hämäläinen, Pedro Andrade, Tomi Paananen, Alejandra Sierra, Jussi Tohka, Olli Gröhn, Asla Pitkänen
Publikováno v:
Biomedicines, Vol 10, Iss 11, p 2721 (2022)
It is necessary to develop reliable biomarkers for epileptogenesis and cognitive impairment after traumatic brain injury when searching for novel antiepileptogenic and cognition-enhancing treatments. We hypothesized that a multiparametric magnetic re
Externí odkaz:
https://doaj.org/article/c63f6e75523345e79282156b0003c5e6
Autor:
Xavier Ekolle Ndode-Ekane, Riikka Immonen, Elina Hämäläinen, Eppu Manninen, Pedro Andrade, Robert Ciszek, Tomi Paananen, Olli Gröhn, Asla Pitkänen
Publikováno v:
Biomedicines, Vol 10, Iss 9, p 2295 (2022)
Brain atrophy induced by traumatic brain injury (TBI) progresses in parallel with epileptogenesis over time, and thus accurate placement of intracerebral electrodes to monitor seizure initiation and spread at the chronic postinjury phase is challengi
Externí odkaz:
https://doaj.org/article/91d84f0b118949bdb0f83b57d7cff234
Seizure Susceptibility and Sleep Disturbance as Biomarkers of Epileptogenesis after Experimental TBI
Autor:
Pedro Andrade, Leonardo Lara-Valderrábano, Eppu Manninen, Robert Ciszek, Jesse Tapiala, Xavier Ekolle Ndode-Ekane, Asla Pitkänen
Publikováno v:
Biomedicines, Vol 10, Iss 5, p 1138 (2022)
Objectives: We investigated whether seizure susceptibility increases over weeks–months after experimental traumatic brain injury (TBI), and whether seizure susceptibility in rats predicts the development of post-traumatic epilepsy (PTE) or epilepti
Externí odkaz:
https://doaj.org/article/7a8daff79c754e27bc188533c92d1c72
Publikováno v:
Neurobiology of Disease, Vol 123, Iss , Pp 42-58 (2019)
A biomarker is a characteristic that is measured as an indicator of normal biologic processes, pathogenic processes, or responses to an exposure or intervention, including therapeutic interventions. Biomarker modalities include molecular, histologic,
Externí odkaz:
https://doaj.org/article/799f11f55bff4bdd8dfc4a23d098fd96