Selected alkylating agents can overcome drug tolerance of G 0 -like tumor cells and eradicate BRCA1-deficient mammary tumors in mice

Autor: Aslι Küçükosmanoğlu, Sven Rottenberg, Maaike Gonggrijp, Rinske Drost, Piet Borst, Charlotte Guyader, Sohvi Blatter, Marina Pajic, Jos Jonkers, Ariena Kersbergen, Wendy Sol

Publikováno v: Clinical Cancer Research
Clinical Cancer Research, 23(22), 7020-7033. American Association for Cancer Research Inc.
Pajic, M, Blatter, S, Guyader, C, Gonggrijp, M, Kersbergen, A, Küçükosmanoğlu, A, Sol, W, Drost, R, Jonkers, J, Borst, P & Rottenberg, S 2017, ' Selected alkylating agents can overcome drug tolerance of G 0-like tumor cells and eradicate BRCA1-deficient mammary tumors in mice ', Clinical Cancer Research, vol. 23, no. 22, pp. 7020-7033 . https://doi.org/10.1158/1078-0432.CCR-17-1279

Purpose: We aimed to characterize and target drug-tolerant BRCA1-deficient tumor cells that cause residual disease and subsequent tumor relapse. Experimental Design: We studied responses to various mono- and bifunctional alkylating agents in a geneti

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