Nickel-Catalyzed Carbonylative Coupling of Alkylzinc Reagents and α-Bromo-α,α-difluoroacetamides

Autor: Troels Skrydstrup, Karoline T. Neumann, Nicklas P. Corneliussen, Ebbe K. Grove, Anne-Sofie O. Schøler, Anton H. Andersen, Aske S. Donslund

Publikováno v: Corneliussen, N P, Grove, E K, Scholer, A S O, Andersen, A, Donslund, A S, Neumann, K T & Skrydstrup, T 2023, ' Nickel-Catalyzed Carbonylative Coupling of Alkylzinc Reagents and α-Bromo-α,α-difluoroacetamides ', Synlett . https://doi.org/10.1055/a-2036-4809

We report a nickel-catalyzed carbonylative cross-coupling of alkyl zinc reagents with α,α-difluorobromoacetamides to obtain α,α,-difluoro-β-ketoamides in moderate to good yields. The reaction is catalyzed by a bench-stable nickel(II) pincer comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb61342dca46130cc058b68f8d278a02
https://pure.au.dk/portal/da/publications/nickelcatalyzed-carbonylative-coupling-of-alkylzinc-reagents-and-bromodifluoroacetamides(7df8f633-ccd0-482f-af8d-2e054e99757c).html

A Nickel(II)-Mediated Thiocarbonylation Strategy for Carbon Isotope Labeling of Aliphatic Carboxamides

Autor: Troels Skrydstrup, Kim B. Jensen, Magnus Gustafsson, Aske S. Donslund, Florian Papp, Simon S. Pedersen, Jesper H. Mikkelsen, Oskar S. Bakholm

Publikováno v: Pedersen, S S, Donslund, A S, Mikkelsen, J H, Bakholm, O S, Papp, F, Jensen, K B, Gustafsson, M B F & Skrydstrup, T 2021, ' A Nickel(II)-Mediated Thiocarbonylation Strategy for Carbon Isotope Labeling of Aliphatic Carboxamides ', Chemistry-A European Journal, vol. 27, no. 24, pp. 7114-7123 . https://doi.org/10.1002/chem.202005261
Chemstry-a european journal

A series of pharmaceutically relevant small molecules and biopharmaceuticals bearing aliphatic carboxamides have been successfully labeled with carbon-13. Key to the success of this novel carbon isotope labeling technique is the observation that 13C-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a896600ec895595fc1841ec7c31246
https://pure.au.dk/portal/da/publications/a-nickeliimediated-thiocarbonylation-strategy-for-carbon-isotope-labeling-of-aliphatic-carboxamides(aee04236-769f-40ca-a0ff-27ee98949f92).html

Direct Access to Isotopically Labeled Aliphatic Ketones Mediated by Nickel(I) Activation

Autor: Cecilie Gaardbo, Charles S. Elmore, Simon S. Pedersen, Aske S. Donslund, Lee P. Kingston, Karoline T. Neumann, Troels Skrydstrup

Publikováno v: Donslund, A S, Pedersen, S S, Gaardbo, C, Neumann, K T, Kingston, L, Elmore, C S & Skrydstrup, T 2020, ' Direct Access to Isotopically Labeled Aliphatic Ketones Mediated by Nickel(I) Activation ', Angewandte Chemie-International Edition, vol. 59, no. 21, pp. 8099-8103 . https://doi.org/10.1002/anie.201916391

An extensive range of functionalized aliphatic ketones with good functional-group tolerance has been prepared by a NiI-promoted coupling of either primary or secondary alkyl iodides with NN2 pincer NiII-acyl complexes. The latter were easily accessed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::810c712c8b301dc953ea66cfd8c8af93
https://pubmed.ncbi.nlm.nih.gov/32017346

Synthesis of Aliphatic Carboxamides Mediated by Nickel NN

Autor: Karoline T, Neumann, Aske S, Donslund, Thomas L, Andersen, Dennis U, Nielsen, Troels, Skrydstrup

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany). 24(56)

The development of a nickel-mediated aminocarbonylation utilizing NN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3715791e2ac00eb003b1608a328ce06c
https://pubmed.ncbi.nlm.nih.gov/30106491

Carbonylative Coupling of Alkyl Zinc Reagents with Benzyl Bromides Catalyzed by a Nickel/NN

Autor: Thomas L, Andersen, Aske S, Donslund, Karoline T, Neumann, Troels, Skrydstrup

Publikováno v: Angewandte Chemie (International ed. in English). 57(3)

An efficient catalytic protocol for the three-component assembly of benzyl bromides, carbon monoxide, and alkyl zinc reagents to give benzyl alkyl ketones is described, and represents the first nickel-catalyzed carbonylative coupling of two sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::014d65f608cfe37dbf9a4c4feb54c4d7
https://pubmed.ncbi.nlm.nih.gov/29193522