Hypoxia compounds exercise-induced free radical formation in humans; partitioning contributions from the cerebral and femoral circulation

Autor: Bailey, Damian M., Rasmussen, Peter, Evans, Kevin A., Bohm, Aske M., Zaar, Morten, Nielsen, Henning B., Brassard, Patrice, Nordsborg, Nikolai B., Homann, Pernille H., Raven, Peter B., McEneny, Jane, Young, Ian S., McCord, Joe M., Secher, Niels H.

Publikováno v: In Free Radical Biology and Medicine 20 August 2018 124:104-113

Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming

Autor: David Olagnier, Aske M. Brandtoft, Camilla Gunderstofte, Nikolaj L. Villadsen, Christian Krapp, Anne L. Thielke, Anders Laustsen, Suraj Peri, Anne Louise Hansen, Lene Bonefeld, Jacob Thyrsted, Victor Bruun, Marie B. Iversen, Lin Lin, Virginia M. Artegoitia, Chenhe Su, Long Yang, Rongtuan Lin, Siddharth Balachandran, Yonglun Luo, Mette Nyegaard, Bernadette Marrero, Raphaela Goldbach-Mansky, Mona Motwani, Dylan G. Ryan, Katherine A. Fitzgerald, Luke A. O’Neill, Anne K. Hollensen, Christian K. Damgaard, Frank v. de Paoli, Hanne C. Bertram, Martin R. Jakobsen, Thomas B. Poulsen, Christian K. Holm

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)

Understanding how regulators of inflammation affect nucleic acid sensing is important for targeting research against inflammatory diseases and conditions. Here, the authors identify Nrf2 as an important negative regulator of STING and suggest a link

Externí odkaz: https://doaj.org/article/5fc54bf6fbd8427c94401b47231854b6

A Novel Do-It-Yourself Approach to Simulating Minimally Invasive Laparoscopic Surgery.

Autor: Wright J; Surgery, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Fort Lauderdale, USA., Joseph AM; Osteopathic Medicine, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Fort Lauderdale, USA., Yassin K; Medicine, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Fort Lauderdale, USA., Fagundo C; Medicine, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Fort Lauderdale, USA., Aske M; Medicine, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Fort Lauderdale, USA., Guntupalli L; Osteopathic Medicine, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Clearwater, USA., Patel R; Medicine, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Fort Lauderdale, USA., McKelvey H; Medicine, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Fort Lauderdale, USA., Goldsmith E; Surgery, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Fort Lauderdale, USA.

Publikováno v: Cureus [Cureus] 2023 May 03; Vol. 15 (5), pp. e38510. Date of Electronic Publication: 2023 May 03 (Print Publication: 2023).

Nitrite and S -Nitrosohemoglobin Exchange Across the Human Cerebral and Femoral Circulation

Autor: Aske M. Bohm, Henning B. Nielsen, Kevin A. Evans, Morten Overgaard, Peter Rasmussen, Niels H. Secher, Damian M. Bailey, Thomas Seifert, Morten Zaar, Patrice Brassard, Peter B. Raven

Publikováno v: Circulation. 135:166-176

Background: The mechanisms underlying red blood cell (RBC)–mediated hypoxic vasodilation remain controversial, with separate roles for nitrite ( ) and S -nitrosohemoglobin (SNO-Hb) widely contested given their ability to transduce nitric oxide bioa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::506a399f9a0bde37632a735aae09db20
https://doi.org/10.1161/circulationaha.116.024226

Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming

Autor: Katherine A. Fitzgerald, Bernadette Marrero, Siddharth Balachandran, Dylan G. Ryan, David Olagnier, Mona Motwani, Frank Vincenzo de Paoli, Marie B. Iversen, Yonglun Luo, Camilla Gunderstofte, Chenhe Su, Martin R. Jakobsen, Jacob Thyrsted, Hanne Christine Bertram, Aske M Brandtoft, Nikolaj L. Villadsen, Anne Kruse Hollensen, Christian K. Holm, Suraj Peri, Anne Louise Hansen, Christian Krapp, Victor Bruun, Long Yang, Virginia M. Artegoitia, Mette Nyegaard, Lin Lin, Anders Laustsen, Anne L. Thielke, Luke A. J. O'Neill, Thomas B. Poulsen, Christian Kroun Damgaard, Rongtuan Lin, Lene Bonefeld, Raphaela Goldbach-Mansky

Publikováno v: Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Olagnier, D, Brandtoft, A M, Gunderstofte, C, Villadsen, N L, Krapp, C, Thielke, A L, Laustsen, A, Peri, S, Hansen, A L, Bonefeld, L, Thyrsted, J, Bruun, V, Iversen, M B, Lin, L, Artegoitia, V M, Su, C, Yang, L, Lin, R, Balachandran, S, Luo, Y, Nyegaard, M, Marrero, B, Goldbach-Mansky, R, Motwani, M, Ryan, D G, Fitzgerald, K A, O'Neill, L A, Hollensen, A K, Damgaard, C K, de Paoli, F V, Bertram, H C, Jakobsen, M R, Poulsen, T B & Holm, C K 2018, ' Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming ', Nature Communications, vol. 9, no. 1, 3506 . https://doi.org/10.1038/s41467-018-05861-7

The transcription factor Nrf2 is a critical regulator of inflammatory responses. If and how Nrf2 also affects cytosolic nucleic acid sensing is currently unknown. Here we identify Nrf2 as an important negative regulator of STING and suggest a link be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5370550ac68fa6f98e5aeab0601064f0
https://pubmed.ncbi.nlm.nih.gov/30158636