Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Ask Püschl"'
Autor:
Lassina Badolo, Kenneth Thirstrup, Søren Møller Nielsen, Ask Püschl, Thomas Jensen, Steve Watson, Christoffer Bundgaard
Publikováno v:
Pharmaceutics, Vol 12, Iss 11, p 1009 (2020)
Drug distribution in the brain is generally associated with an affinity for fatty brain tissues and therefore known to be species- and concentration-independent. We report here the effect of target affinity on brain tissue binding for 10 small molecu
Externí odkaz:
https://doaj.org/article/bc746fabbc864499855246d15fe4e287
Autor:
Christoffer Bundgaard, Søren Møller Nielsen, Kenneth Thirstrup, Lassina Badolo, Steve Watson, Ask Püschl, Thomas Jensen
Publikováno v:
Pharmaceutics
Volume 12
Issue 11
Pharmaceutics, Vol 12, Iss 1009, p 1009 (2020)
Volume 12
Issue 11
Pharmaceutics, Vol 12, Iss 1009, p 1009 (2020)
Drug distribution in the brain is generally associated with an affinity for fatty brain tissues and therefore known to be species- and concentration-independent. We report here the effect of target affinity on brain tissue binding for 10 small molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c383242eff5a0424803340fb436961b
https://doi.org/10.3390/pharmaceutics12111009
https://doi.org/10.3390/pharmaceutics12111009
Publikováno v:
Synthesis. 47:3231-3240
1,3-Amino alcohols were prepared by using a two-step approach and an interesting reversal in diastereoselectivity is discussed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d0c79f9d6f133dd3a4686ab3bed4298
https://doi.org/10.1055/s-0034-1378854
https://doi.org/10.1055/s-0034-1378854
Autor:
Anders Ettrup, Jacob Madsen, Ask Püschl, Lassina Badolo, Gitte M. Knudsen, Thomas Balle, Szabolcs Lehel, Jesper L. Kristensen, Agnete Dyssegaard, Benny Bang-Andersen, Rune Risgaard, Henrik Pedersen, Hanne D. Hansen
Publikováno v:
Nuclear Medicine and Biology. 40:135-140
Cerebral α₁-adrenoceptors are a common target for many antipsychotic drugs. Thus, access to positron emission tomography (PET) brain imaging of α₁-adrenoceptors could make important contributions to the understanding of psychotic disorders as w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dac9a40bc91e2f4c0810363cf17a296a
https://doi.org/10.1016/j.nucmedbio.2012.09.010
https://doi.org/10.1016/j.nucmedbio.2012.09.010
Publikováno v:
Tetrahedron Letters. 39:4707-4710
The synthesis of 10 new T-PNA monomers derived from L-amino acids is presented. The monomers were incorporated into decameric PNA oligomers, and the hybridisation with RNA, DNA and PNA complements studied by thermal stability measurements.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2b5013864a7b2e8af62b678c95c5023
https://doi.org/10.1016/s0040-4039(98)00862-4
https://doi.org/10.1016/s0040-4039(98)00862-4
Autor:
Per Halfdan Nielsen, Kurt V. Mikkelsen, Marianne Gockeln, Alexander Senning, Martin aus dem Kahmen, Ask Püschl, Hans J. Schäfer, Andreas Weiper-Idelmann
Publikováno v:
Acta Chemica Scandinavica. 52:672-682
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64563a9b8845dbeed5d8f19cbd849612
https://doi.org/10.3891/acta.chem.scand.52-0672
https://doi.org/10.3891/acta.chem.scand.52-0672
Autor:
Sine Larsen, Kurt V. Mikkelsen, Pia B. Holst, Ask Püschl, Carsten Christophersen, Alexander Senning, Per Halfdan Nielsen, Uffe Anthoni
Publikováno v:
Acta Chemica Scandinavica. 52:683-693
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dabccd6e24520683168bf55f236f4d2d
https://doi.org/10.3891/acta.chem.scand.52-0683
https://doi.org/10.3891/acta.chem.scand.52-0683
Publikováno v:
Nucleosides and Nucleotides. 16:1633-1636
A phosphotriester method for the synthesis of dithymidine phosphoromonothoates and phosphorodithioates with new S-protecting groups has been investigated. Four of the S-protecting groups possesed catalytic activity, however side reactions occurred du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5db1db6082e00a1a7dc3a19bfec47a4f
https://doi.org/10.1080/07328319708006243
https://doi.org/10.1080/07328319708006243
Publikováno v:
Nucleosides and Nucleotides. 16:23-32
ABSTRACT A method for the synthesis of O-thymidin-3′-yl S-alkyl dithiophosphate monomers 1 with different S-protecting groups has been developed. These have been used for solution phase synthesis of dithymidine phosphorodithioate by a new phosphotr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::047c9aa796b9c5a3dd2ccddc831bc48b
https://doi.org/10.1080/07328319708002518
https://doi.org/10.1080/07328319708002518
Publikováno v:
Nucleosides and Nucleotides. 16:145-158
ABSTRACT A phosphotriester method for the synthesis of dithymidine phosphorothioates with eight S-protecting groups has been investigated. Three of the S-protecting groups possesed catalytic activity, however side reactions occurred under deprotectio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cdfaae44662090ee0a23f48cb60fcfa
https://doi.org/10.1080/07328319708002529
https://doi.org/10.1080/07328319708002529