Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Asin, Peighambari"'
Autor:
Philipp Seidel, Anne Rubarth, Kyra Zodel, Asin Peighambari, Felix Neumann, Yannick Federkiel, Hsin Huang, Rouven Hoefflin, Mojca Adlesic, Christian Witt, David J. Hoffmann, Patrick Metzger, Ralph K. Lindemann, Frank T. Zenke, Christoph Schell, Melanie Boerries, Dominik von Elverfeldt, Wilfried Reichardt, Marie Follo, Joachim Albers, Ian J. Frew
Publikováno v:
JCI Insight, Vol 7, Iss 24 (2022)
Metastatic clear cell renal cell carcinomas (ccRCCs) are resistant to DNA-damaging chemotherapies, limiting therapeutic options for patients whose tumors are resistant to tyrosine kinase inhibitors and/or immune checkpoint therapies. Here we show tha
Externí odkaz:
https://doaj.org/article/cf8515a3861b40da82fdcd8f12d444bb
Autor:
Daniel A. Mohl, Simon Lagies, Kyra Zodel, Matthias Zumkeller, Asin Peighambari, Athina Ganner, Dietmar A. Plattner, Elke Neumann-Haefelin, Mojca Adlesic, Ian J. Frew, Bernd Kammerer
Publikováno v:
Cells, Vol 12, Iss 8, p 1102 (2023)
Clear cell renal cell carcinoma (ccRCC) accounts for ~75% of kidney cancers. The biallelic inactivation of the von Hippel–Lindau tumor suppressor gene (VHL) is the truncal driver mutation of most cases of ccRCC. Cancer cells are metabolically repro
Externí odkaz:
https://doaj.org/article/c14feeae9dc44cb78d95daac398001d5
Autor:
Rouven Hoefflin, Sabine Harlander, Silvia Schäfer, Patrick Metzger, Fengshen Kuo, Désirée Schönenberger, Mojca Adlesic, Asin Peighambari, Philipp Seidel, Chia-yi Chen, Miguel Consenza-Contreras, Andreas Jud, Bernd Lahrmann, Niels Grabe, Danijela Heide, Franziska M. Uhl, Timothy A. Chan, Justus Duyster, Robert Zeiser, Christoph Schell, Mathias Heikenwalder, Oliver Schilling, A. Ari Hakimi, Melanie Boerries, Ian J. Frew
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
Genetic inactivation of VHL leads to stabilization of HIF-1α/HIF-2α and is associated with clear cell renal cell carcinoma (ccRCC) initiation and progression. Using an autochthonous mouse model of ccRCC with Vhl deletion, here the authors show that
Externí odkaz:
https://doaj.org/article/c9223cd55c18449db9d005eb65c4887e
Publikováno v:
Handbook of Cancer and Immunology ISBN: 9783030809621
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12fd503c59b3609fbe6d4d3884804f39
https://doi.org/10.1007/978-3-030-80962-1_185-1
https://doi.org/10.1007/978-3-030-80962-1_185-1
Autor:
Behnaz A. Abhari, Melanie Boerries, Danijela Heide, Stefan Haug, Sabine Harlander, Niels Grabe, Burulca Göcmen, Philipp Seidel, Anna Köttgen, Mojca Adlesic, Ian J. Frew, Kyra Zodel, Asin Peighambari, Bernd Lahrmann, Mathias Heikenwalder, Yong Li, Rouven Hoefflin
Publikováno v:
Cancers
Cancers, Vol 13, Iss 4801, p 4801 (2021)
Volume 13
Issue 19
Cancers, Vol 13, Iss 4801, p 4801 (2021)
Volume 13
Issue 19
Simple Summary Clear cell renal cell carcinoma is a common malignancy that represents 80% of all kidney tumors. Most tumors harbor an inactivation of the VHL gene, leading to the accumulation of HIF-1α and HIF-2α. Promising clinical results of spec