Zobrazeno 1 - 10 of 28 pro vyhledávání: '"Asim Kumar Debnath"'
1
Solution Structure of a Hydrocarbon Stapled Peptide Inhibitor in Complex with Monomeric C-terminal Domain of HIV-1 Capsid
Autor: Asim Kumar Debnath, Shibani Bhattacharya, David Cowburn, Hongtao Zhang
Publikováno v: Journal of Biological Chemistry. 283:16274-16278
The human immunodeficiency virus type 1 (HIV-1) capsid protein plays a critical role in virus core particle assembly and is an important target for novel therapeutic strategies. In a previous study, we characterized the binding affinity of a hydrocar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee4abed1b0b996b87bafdb2549791489
https://doi.org/10.1074/jbc.c800048200
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2
A Cell-penetrating Helical Peptide as a Potential HIV-1 Inhibitor
Autor: Susanne Heck, Michael Goger, Qian Zhao, Xiaohe Tong, Anita Hong, David Cowburn, Shibani Bhattacharya, Hongtao Zhang, Eric O. Freed, Abdul A. Waheed, Francesca Curreli, Asim Kumar Debnath
Publikováno v: Journal of Molecular Biology. 378:565-580
The capsid domain of the human immunodeficiency virus type 1 (HIV-1) Gag polyprotein is a critical determinant of virus assembly, and is therefore a potential target for developing drugs for AIDS therapy. Recently, a 12-mer alpha-helical peptide (CAI
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edb49b598f53950fde0bf6393abfa035
https://doi.org/10.1016/j.jmb.2008.02.066
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3
Identification of N-phenyl-N′-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamides as a new class of HIV-1 entry inhibitors that prevent gp120 binding to CD4
Autor: Liying Ma, Hong Lu, Shuwen Liu, Nathan Strick, Nouri Neamati, Asim Kumar Debnath, Yuxian He, Shibo Jiang, Qian Zhao
Publikováno v: Virology. 339(2):213-225
We have identified two N-phenyl-N'-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamide analogs as a novel class of human immunodeficiency virus type 1 (HIV-1) entry inhibitors that block the gp120-CD4 interaction, using database screening techniques. The
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50e64064b579293323beb0cedaee19ee
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4
Theaflavin derivatives in black tea and catechin derivatives in green tea inhibit HIV-1 entry by targeting gp41
Autor: Jinkui Niu, Shuwen Liu, Hong Lu, Shibo Jiang, Shuguang Wu, Asim Kumar Debnath, Qian Zhao, Yuxian He
Publikováno v: Biochimica et Biophysica Acta (BBA) - General Subjects. 1723:270-281
Theaflavin derivatives and catechin derivatives are the major polyphenols in black tea and green tea, respectively. Several tea polyphenols, especially those with galloyl moiety, can inhibit HIV-1 replication with multiple mechanisms of action. Here
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f8e8b54fca691d514f012ecbebc7dbf
https://doi.org/10.1016/j.bbagen.2005.02.012
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5
N-Substituted Pyrrole Derivatives as Novel Human Immunodeficiency Virus Type 1 Entry Inhibitors That Interfere with the gp41 Six-Helix Bundle Formation and Block Virus Fusion
Autor: Shuwen Liu, Yuxian He, Asim Kumar Debnath, Qian Zhao, Shibo Jiang, Hong Lu
Publikováno v: Antimicrobial Agents and Chemotherapy. 48:4349-4359
A recently approved peptidic human immunodeficiency virus type 1 (HIV-1) fusion inhibitor, T-20 (Fuzeon; Trimeris Inc.), has shown significant promise in clinical application for treating HIV-1-infected individuals who have failed to respond to the c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd47e7b2684455098afe08d847d5fe2a
https://doi.org/10.1128/aac.48.11.4349-4359.2004
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6
Pharmacophore Mapping of a Series of 2,4-Diamino-5-deazapteridine Inhibitors of Mycobacterium avium Complex Dihydrofolate Reductase
Autor: Asim Kumar Debnath
Publikováno v: Journal of Medicinal Chemistry. 45:41-53
Pharmacophore hypotheses were developed for a series of 2,4-diamino-5-deazapteridine inhibitors of Mycobacterium avium complex (MAC) and human dihydrofolate reductase (hDHFR). Training sets consisting of 20 inhibitors were selected in each case on th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34886efdf8f1338346dcfde123d132fe
https://doi.org/10.1021/jm010360c
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8
Structure-Based Identification of Small Molecule Antiviral Compounds Targeted to the gp41 Core Structure of the Human Immunodeficiency Virus Type 1
Autor: Lin Radigan, Shibo Jiang, Asim Kumar Debnath
Publikováno v: Journal of Medicinal Chemistry. 42:3203-3209
Recent X-ray crystallographic determination of the HIV-1 envelope glycoprotein gp41 core structure opened up a new avenue to discover antiviral agents for chemotherapy of HIV-1 infection and AIDS. We have undertaken a systematic study to search for a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b60974bbd0d15aa70a39f07df686e05
https://doi.org/10.1021/jm990154t
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9
A screening assay for antiviral compounds targeted to the HIV-1 gp41 core structure using a conformation-specific monoclonal antibody
Autor: Kang Lin, Li Zhang, Shibo Jiang, Asim Kumar Debnath
Publikováno v: Journal of Virological Methods. 80:85-96
The human immunodeficiency virus type 1 (HIV-1) gp41 plays an important role in membrane fusion between viruses and target cells. The gp41 ectodomain contains two heptad repeat regions adjacent to the N and C-termini. Peptides derived from these two
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56367608a2a3091e173702d4abc313c0
https://doi.org/10.1016/s0166-0934(99)00041-5
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