Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Asim K. Debnath"'
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-21 (2022)
Abstract Background Zika virus (ZIKV) and dengue virus (DENV) cause microcephaly and dengue hemorrhagic fever, respectively, leading to severe problems. No effective antiviral agents are approved against infections of these flaviviruses, calling for
Externí odkaz:
https://doaj.org/article/449d921bd4a64820897f1ecb589e5c98
Autor:
Francesca Curreli, Kent Chau, Thanh-Thuy Tran, Isabella Nicolau, Shahad Ahmed, Pujita Das, Christopher D. Hillyer, Mary Premenko-Lanier, Asim K. Debnath
Publikováno v:
Viruses, Vol 15, Iss 4, p 1001 (2023)
The unprecedented pandemic of COVID-19, caused by a novel coronavirus, SARS-CoV-2, and its highly transmissible variants, led to massive human suffering, death, and economic devastation worldwide. Recently, antibody-evasive SARS-CoV-2 subvariants, BQ
Externí odkaz:
https://doaj.org/article/c53028b7761f4c8395a20977fa827cf7
Autor:
Cheryl A. Stoddart, Francesca Curreli, Stephen Horrigan, Andrea Altieri, Alexander V. Kurkin, Asim K. Debnath
Publikováno v:
Viruses, Vol 14, Iss 10, p 2268 (2022)
We earlier reported substantial progress in designing gp120 antagonists. Notably, we discovered that NBD-14189 is not only the most active gp120 antagonist but also shows antiviral activity against HIV-1 Reverse Transcriptase (RT). We also confirmed
Externí odkaz:
https://doaj.org/article/1463e85e990844aa80b6235ea3c21d30
Autor:
Francesca Curreli, Sofia M. B. Victor, Shahad Ahmed, Aleksandra Drelich, Xiaohe Tong, Chien-Te K. Tseng, Christopher D. Hillyer, Asim K. Debnath
Publikováno v:
mBio, Vol 11, Iss 6 (2020)
ABSTRACT SARS-CoV-2 uses human angiotensin-converting enzyme 2 (ACE2) as the primary receptor to enter host cells and initiate the infection. The critical binding region of ACE2 is an ∼30-amino-acid (aa)-long helix. Here, we report the design of fo
Externí odkaz:
https://doaj.org/article/7459b0c8aaa2467f833de234e555f435
Autor:
Francesca Curreli, Shahad Ahmed, Sofia M. B. Victor, Aleksandra Drelich, Siva S. Panda, Andrea Altieri, Alexander V. Kurkin, Chien-Te K. Tseng, Christopher D. Hillyer, Asim K. Debnath
Publikováno v:
Viruses, Vol 14, Iss 1, p 69 (2021)
We report the discovery of several highly potent small molecules with low-nM potency against severe acute respiratory syndrome coronavirus (SARS-CoV; lowest half-maximal inhibitory concentration (IC50: 13 nM), SARS-CoV-2 (IC50: 23 nM), and Middle Eas
Externí odkaz:
https://doaj.org/article/447c4795eeaa4a548022ea9c515c5a92
Publikováno v:
Viruses, Vol 12, Iss 6, p 609 (2020)
Combination antiretroviral therapy (cART) is successful in maintaining undetectable levels of HIV in the blood; however, the persistence of latent HIV reservoirs has become the major barrier for a HIV cure. Substantial efforts are underway in finding
Externí odkaz:
https://doaj.org/article/bcb5c66abb4a4a2daa37d50eb8f04a75
Autor:
Yaning Gao, Wanbo Tai, Ning Wang, Xiang Li, Shibo Jiang, Asim K. Debnath, Lanying Du, Shizhong Chen
Publikováno v:
Viruses, Vol 11, Iss 11, p 1019 (2019)
Zika virus (ZIKV) infection during pregnancy leads to severe congenital Zika syndrome, which includes microcephaly and other neurological malformations. No therapeutic agents have, so far, been approved for the treatment of ZIKV infection in humans;
Externí odkaz:
https://doaj.org/article/c30affd3ee214ba09643c31a859dbbf8
Publikováno v:
Viruses, Vol 5, Iss 1, Pp 127-149 (2013)
The hydrophobic pocket in the HIV-1 gp41 N-terminal heptad repeat (NHR) domain plays an important role in viral fusion and entry into the host cell, and serves as an attractive target for development of HIV-1 fusion/entry inhibitors. The peptide anti
Externí odkaz:
https://doaj.org/article/27a55223ece34634bd6d7e03a80f7a14
Autor:
Alexander V. Kurkin, Francesca Curreli, Ildar R. Iusupov, Evgeniy A. Spiridonov, Shahad Ahmed, Pavel O. Markov, Ekaterina V. Manasova, Andrea Altieri, Asim K. Debnath
Publikováno v:
ChemMedChem. 17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49becfb936d25962cc0ae7361a012701
https://doi.org/10.1002/cmdc.202200600
https://doi.org/10.1002/cmdc.202200600
Autor:
Alexander V. Kurkin, Francesca Curreli, Ildar R. Iusupov, Evgeniy A. Spiridonov, Shahad Ahmed, Pavel O. Markov, Ekaterina V. Manasova, Andrea Altieri, Asim K. Debnath
Publikováno v:
ChemMedChem. 17
The envelope glycoprotein gp120 of human immunodeficiency virus type 1 (HIV-1) plays a critical role in virus entry to the cells by binding to the host cellular protein CD4. Earlier, we reported the design and discovery of a series of highly potent s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0ed7d434eea3aa29556c274a618b47
https://doi.org/10.1002/cmdc.202200344
https://doi.org/10.1002/cmdc.202200344