Výsledky vyhledávání - "Asier Ullate-Agote"

Akademický článek

PMEL is involved in snake colour pattern transition from blotches to stripes

Autor: Athanasia C. Tzika, Asier Ullate-Agote, Pierre-Yves Helleboid, Maya Kummrow

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

Abstract Corn snakes are emerging models for animal colouration studies. Here, we focus on the Terrazzo morph, whose skin pattern is characterized by stripes rather than blotches. Using genome mapping, we discover a disruptive mutation in the coding

Externí odkaz: https://doaj.org/article/1f9147a2b94347b4844246365cac2730

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Akademický článek

Single-cell transcriptional profile of CD34+ hematopoietic progenitor cells from del(5q) myelodysplastic syndromes and impact of lenalidomide

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Abstract While myelodysplastic syndromes with del(5q) (del(5q) MDS) comprises a well-defined hematological subgroup, the molecular basis underlying its origin remains unknown. Using single cell RNA-seq (scRNA-seq) on CD34+ progenitors from del(5q) MD

Externí odkaz: https://doaj.org/article/91536052d5734ebda987ce77dddb892b

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Akademický článek

Revealing cell populations catching the early stages of human embryo development in naive pluripotent stem cell cultures

Autor: Marta Moya-Jódar, Asier Ullate-Agote, Paula Barlabé, Juan Roberto Rodríguez-Madoz, Gloria Abizanda, Carolina Barreda, Xonia Carvajal-Vergara, Amaia Vilas-Zornoza, Juan Pablo Romero, Leire Garate, Xabier Agirre, Giulia Coppiello, Felipe Prósper, Xabier L. Aranguren

Publikováno v: Stem Cell Reports, Vol 18, Iss 1, Pp 64-80 (2023)

Summary: Naive human pluripotent stem cells (hPSCs) are defined as the in vitro counterpart of the human preimplantation embryo’s epiblast and are used as a model system to study developmental processes. In this study, we report the discovery and c

Externí odkaz: https://doaj.org/article/5525088ab778485bae0f0d5d92dd1f1f

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Akademický článek

Loss of the matrix metalloproteinase-10 causes premature features of aging in satellite cells

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 11 (2023)

Aged muscles accumulate satellite cells with a striking decline response to damage. Although intrinsic defects in satellite cells themselves are the major contributors to aging-associated stem cell dysfunction, increasing evidence suggests that chang

Externí odkaz: https://doaj.org/article/6f3b235d66ea48b0903667a7547e22f3

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Akademický článek

Gene therapy restores the transcriptional program of hematopoietic stem cells in Fanconi anemia

Publikováno v: Haematologica, Vol 108, Iss 10 (2023)

Clinical trials have shown that lentiviral-mediated gene therapy can ameliorate bone marrow failure (BMF) in nonconditioned Fanconi anemia (FA) patients resulting from the proliferative advantage of corrected FA hematopoietic stem and progenitor cell

Externí odkaz: https://doaj.org/article/d53a95898f024aef96171022924acc08

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Akademický článek

Impact of genome architecture on the functional activation and repression of Hox regulatory landscapes

Autor: Eddie Rodríguez-Carballo, Lucille Lopez-Delisle, Nayuta Yakushiji-Kaminatsui, Asier Ullate-Agote, Denis Duboule

Publikováno v: BMC Biology, Vol 17, Iss 1, Pp 1-18 (2019)

Abstract Background The spatial organization of the mammalian genome relies upon the formation of chromatin domains of various scales. At the level of gene regulation in cis, collections of enhancer sequences define large regulatory landscapes that u

Externí odkaz: https://doaj.org/article/b255e7e9ff67451090d74138326008be

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Akademický článek

One-Step In Vitro Generation of ETV2-Null Pig Embryos

Autor: Marta Moya-Jódar, Giulia Coppiello, Juan Roberto Rodríguez-Madoz, Gloria Abizanda, Paula Barlabé, Amaia Vilas-Zornoza, Asier Ullate-Agote, Chiara Luongo, Ernesto Rodríguez-Tobón, Sergio Navarro-Serna, Evelyne París-Oller, Maria Oficialdegui, Xonia Carvajal-Vergara, Laura Ordovás, Felipe Prósper, Francisco Alberto García-Vázquez, Xabier L. Aranguren

Publikováno v: Animals, Vol 12, Iss 14, p 1829 (2022)

Each year, tens of thousands of people worldwide die of end-stage organ failure due to the limited availability of organs for use in transplantation. To meet this clinical demand, one of the last frontiers of regenerative medicine is the generation o

Externí odkaz: https://doaj.org/article/008bc07603ad4bfbbc64171c81d1b08e

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Akademický článek

Characterization of the Leucistic Texas Rat Snake Pantherophis obsoletus

Autor: Asier Ullate-Agote, Athanasia C. Tzika

Publikováno v: Frontiers in Ecology and Evolution, Vol 9 (2021)

Albinism and leucism are phenotypes resulting from impaired melanin pigmentation in the skin and skin appendages. However, melanin pigmentation of eyes remains unaffected in leucism. Here, using transmission electron microscopy, we show that the leuc

Externí odkaz: https://doaj.org/article/ac9bf7fa6d24434484ff723edca047a8

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