Zobrazeno 1 - 10 of 82 pro vyhledávání: '"Asiedu Marina N"'
1
Akademický článek
Resveratrol engages AMPK to attenuate ERK and mTOR signaling in sensory neurons and inhibits incision-induced acute and chronic pain
Autor: Tillu Dipti V, Melemedjian Ohannes K, Asiedu Marina N, Qu Ning, De Felice Milena, Dussor Gregory, Price Theodore J
Publikováno v: Molecular Pain, Vol 8, Iss 1, p 5 (2012)
Abstract Background Despite advances in our understanding of basic mechanisms driving post-surgical pain, treating incision-induced pain remains a major clinical challenge. Moreover, surgery has been implicated as a major cause of chronic pain condit
Externí odkaz: https://doaj.org/article/34b1a74694de4eac8d1d4403e86538fc
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2
Akademický článek
Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic pain
Autor: Peebles Katherine A, Johnson Jessica, Khoutorsky Arkady, Lark Arianna, Yan Jin, Sanoja Raul, Tillu Dipti V, Asiedu Marina N, Melemedjian Ohannes K, Lepow Talya, Sonenberg Nahum, Dussor Gregory, Price Theodore J
Publikováno v: Molecular Pain, Vol 7, Iss 1, p 70 (2011)
Abstract Neuropathic pain is a debilitating clinical condition with few efficacious treatments, warranting development of novel therapeutics. We hypothesized that dysregulated translation regulation pathways may underlie neuropathic pain. Peripheral
Externí odkaz: https://doaj.org/article/a38a04b5bb5e44aa891d8ad7ba3186d7
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3
Akademický článek
eIF4E Phosphorylation Influences Bdnf mRNA Translation in Mouse Dorsal Root Ganglion Neurons
Autor: Moy, Jamie K., Khoutorsky, Arkady, Asiedu, Marina N., Dussor, Gregory, Price, Theodore J.
Plasticity in dorsal root ganglion (DRG) neurons that promotes pain requires activity-dependent mRNA translation. Protein synthesis inhibitors block the ability of many pain-promoting molecules to enhance excitability in DRG neurons and attenuate beh
Externí odkaz: http://hdl.handle.net/10150/627082
http://arizona.openrepository.com/arizona/handle/10150/627082
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6
Akademický článek
The AMPK Activator A769662 Blocks Voltage-Gated Sodium Channels: Discovery of a Novel Pharmacophore with Potential Utility for Analgesic Development
Autor: Asiedu, Marina N., Han, Chongyang, Dib-Hajj, Sulayman D., Waxman, Stephen G., Price, Theodore J., Dussor, Gregory
Voltage-gated sodium channels (VGSC) regulate neuronal excitability by governing action potential (AP) generation and propagation. Recent studies have revealed that AMP-activated protein kinase (AMPK) activators decrease sensory neuron excitability,
Externí odkaz: http://hdl.handle.net/10150/623094
http://arizona.openrepository.com/arizona/handle/10150/623094
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9
The novel PAR2 ligand C391 blocks multiple PAR2 signalling pathways in vitro and in vivo
Autor: Boitano, Scott, Hoffman, Justin, Flynn, Andrea N, Asiedu, Marina N, Tillu, Dipti V, Zhang, Zhenyu, Sherwood, Cara L, Rivas, Candy M, DeFea, Kathryn A, Vagner, Josef, Price, Theodore J
Publikováno v: British journal of pharmacology, vol 172, iss 18
Background and purposeProteinase-activated receptor-2 (PAR2) is a GPCR linked to diverse pathologies, including acute and chronic pain. PAR2 is one of the four PARs that are activated by proteolytic cleavage of the extracellular amino terminus, resul
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::976d1185f26a633e5c50f335c2c63c4d
https://escholarship.org/uc/item/3r54m6fb
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10
Akademický článek
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