Výsledky vyhledávání - "Asiedu, Marina"

Akademický článek

eIF4E Phosphorylation Influences Bdnf mRNA Translation in Mouse Dorsal Root Ganglion Neurons

Autor: Moy, Jamie K., Khoutorsky, Arkady, Asiedu, Marina N., Dussor, Gregory, Price, Theodore J.

Plasticity in dorsal root ganglion (DRG) neurons that promotes pain requires activity-dependent mRNA translation. Protein synthesis inhibitors block the ability of many pain-promoting molecules to enhance excitability in DRG neurons and attenuate beh

Externí odkaz: http://hdl.handle.net/10150/627082
http://arizona.openrepository.com/arizona/handle/10150/627082

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Akademický článek

The MNK–eIF4E Signaling Axis Contributes to Injury-Induced Nociceptive Plasticity and the Development of Chronic Pain

Autor: Moy, Jamie K., Khoutorsky, Arkady, Asiedu, Marina N., Black, Bryan J., Kuhn, Jasper L., Barragán-Iglesias, Paulino, Megat, Salim, Burton, Michael D., Burgos-Vega, Carolina C., Melemedjian, Ohannes K., Boitano, Scott, Vagner, Josef, Gkogkas, Christos G., Pancrazio, Joseph J., Mogil, Jeffrey S., Dussor, Gregory, Sonenberg, Nahum, Price, Theodore J.

Injury-induced sensitization of nociceptors contributes to pain states and the development of chronic pain. Inhibiting activity-dependent mRNA translation through mechanistic target of rapamycin and mitogen-activated protein kinase (MAPK) pathways bl

Externí odkaz: http://hdl.handle.net/10150/625494
http://arizona.openrepository.com/arizona/handle/10150/625494

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Akademický článek

The AMPK Activator A769662 Blocks Voltage-Gated Sodium Channels: Discovery of a Novel Pharmacophore with Potential Utility for Analgesic Development

Autor: Asiedu, Marina N., Han, Chongyang, Dib-Hajj, Sulayman D., Waxman, Stephen G., Price, Theodore J., Dussor, Gregory

Voltage-gated sodium channels (VGSC) regulate neuronal excitability by governing action potential (AP) generation and propagation. Recent studies have revealed that AMP-activated protein kinase (AMPK) activators decrease sensory neuron excitability,

Externí odkaz: http://hdl.handle.net/10150/623094
http://arizona.openrepository.com/arizona/handle/10150/623094

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Akademický článek

Local translation and retrograde axonal transport of CREB regulates IL-6-induced nociceptive plasticity

Autor: Melemedjian, Ohannes, Tillu, Dipti, Moy, Jamie, Asiedu, Marina, Mandell, Edward, Ghosh, Sourav, Dussor, Gregory, Price, Theodore

Transcriptional regulation of genes by cyclic AMP response element binding protein (CREB) is essential for the maintenance of long-term memory. Moreover, retrograde axonal trafficking of CREB in response to nerve growth factor (NGF) is critical for t

Externí odkaz: http://hdl.handle.net/10150/610222
http://arizona.openrepository.com/arizona/handle/10150/610222

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Akademický článek

BDNF regulates atypical PKC at spinal synapses to initiate and maintain a centralized chronic pain state

Autor: Melemedjian, Ohannes, Tillu, Dipti, Asiedu, Marina, Mandell, Edward, Moy, Jamie, Blute, Victoria, Taylor, Caleb, Ghosh, Sourav, Price, Theodore

BACKGROUND:Chronic pain is an important medical problem affecting hundreds of millions of people worldwide. Mechanisms underlying the maintenance of chronic pain states are poorly understood but the elucidation of such mechanisms have the potential t

Externí odkaz: http://hdl.handle.net/10150/610217
http://arizona.openrepository.com/arizona/handle/10150/610217

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Akademický článek

Resveratrol engages AMPK to attenuate ERK and mTOR signaling in sensory neurons and inhibits incision-induced acute and chronic pain

Autor: Tillu, Dipti, Melemedjian, Ohannes, Asiedu, Marina, Qu, Ning, De Felice, Milena, Dussor, Gregory, Price, Theodore

BACKGROUND:Despite advances in our understanding of basic mechanisms driving post-surgical pain, treating incision-induced pain remains a major clinical challenge. Moreover, surgery has been implicated as a major cause of chronic pain conditions. Hen

Externí odkaz: http://hdl.handle.net/10150/610215
http://arizona.openrepository.com/arizona/handle/10150/610215

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Akademický článek

Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic pain

Autor: Melemedjian, Ohannes, Asiedu, Marina, Tillu, Dipti, Sanoja, Raul, Yan, Jin, Lark, Arianna, Khoutorsky, Arkady, Johnson, Jessica, Peebles, Katherine, Lepow, Talya, Sonenberg, Nahum, Dussor, Gregory, Price, Theodore

Neuropathic pain is a debilitating clinical condition with few efficacious treatments, warranting development of novel therapeutics. We hypothesized that dysregulated translation regulation pathways may underlie neuropathic pain. Peripheral nerve inj

Externí odkaz: http://hdl.handle.net/10150/610214
http://arizona.openrepository.com/arizona/handle/10150/610214

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Dissertation/ Thesis

Spinal Sensitization Mechanisms Promoting Pain: Gabaergic Disinhibition and Pkmζ-Mediated Plasticity

Autor: Asiedu, Marina N.

As a major public health problem affecting more that 76.5 million Americans, chronic pain is one main reason why people seek medical attention. It is a pathological nervous system disorder that persists for months or years. Sensitization of nocicepti

Externí odkaz: http://hdl.handle.net/10150/232496

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