Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Ashwni, Verma"'
Publikováno v:
Pharmaceutics, Vol 16, Iss 10, p 1259 (2024)
Objective: This study aimed to investigate the effect of molecular size on the pulmonary pharmacokinetics (PK) of proteins following systemic and local administration in wild-type mice. Methods: A non-cross-reactive antibody trastuzumab, and F(ab′)
Externí odkaz:
https://doaj.org/article/e5f84f60190e4daca7287ea24db21f88
Autor:
Miaomiao Li, Chih Yean Ong, Christophe J Langouët-Astrié, Lisi Tan, Ashwni Verma, Yimu Yang, Xiaoxiao Zhang, Dhaval K Shah, Eric P Schmidt, Ding Xu
Publikováno v:
eLife, Vol 11 (2022)
RAGE, a druggable inflammatory receptor, is known to function as an oligomer but the exact oligomerization mechanism remains poorly understood. Previously we have shown that heparan sulfate (HS) plays an active role in RAGE oligomerization. To unders
Externí odkaz:
https://doaj.org/article/fd4241c108454ee0ac24b569c2771b24
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
A growing body of evidence supports the important role of molecular charge on antibody pharmacokinetics (PK), yet a quantitative description of the effect of charge on systemic and tissue disposition of antibodies is still lacking. Consequently, we h
Externí odkaz:
https://doaj.org/article/e73ce0565b654394aa4bd90e5fc450a1
Publikováno v:
Journal of Pharmaceutical Sciences.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e431f1b5b60dc8ba9e3a67b3650a2bb
https://doi.org/10.1016/j.xphs.2023.04.006
https://doi.org/10.1016/j.xphs.2023.04.006
Publikováno v:
Pharmaceutics, Vol 11, Iss 2, p 98 (2019)
Here, we have presented the development of a systems pharmacokinetics-pharmacodynamics (PK-PD) model for antibody-drug conjugates (ADCs), which uses intracellular target occupancy to drive in-vivo efficacy. The model is built based on PK and efficacy
Externí odkaz:
https://doaj.org/article/4291c1938749488fa8630dc64bde2251
Autor:
Gloria Gao-Li Wong, Dhaval K. Shah, Aman P. Singh, Leiming Guo, Ashwni Verma, Gail M. Seigel, Hsuan-Ping Cheng
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 374:184-199
The objective of this work was to develop a systems pharmacokinetics-pharmacodynamics (PK-PD) model that can characterize in vivo bystander effect of antibody-drug conjugate (ADC) in a heterogeneous tumor. To accomplish this goal, a coculture xenogra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9aa45b8b18a3e4b0b20d34ac027bde7
https://doi.org/10.1124/jpet.119.262287
https://doi.org/10.1124/jpet.119.262287
Autor:
Miaomiao Li, Chih Yean Ong, Christophe J Langouët-Astrié, Lisi Tan, Ashwni Verma, Yimu Yang, Xiaoxiao Zhang, Dhaval K Shah, Eric P Schmidt, Ding Xu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1e54c6c086845a2f6f70e078e90b07d
https://doi.org/10.7554/elife.71403.sa2
https://doi.org/10.7554/elife.71403.sa2
Autor:
Hsuan-Ping Chang, Leiming Guo, David Bussing, Zhe Li, Ashwni Verma, Dhaval K. Shah, Hsueh-Yuan Chang, Yingyi Li
Publikováno v:
The AAPS Journal
The ocular pharmacokinetics (PK) of antibody-based therapies are infrequently studied in mice due to the technical difficulties in working with the small murine eye. This study is the first of its kind to quantitatively measure the PK of variously si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a1abeb938dac19b2d599151c1c5656b
https://doi.org/10.1208/s12248-021-00647-0
https://doi.org/10.1208/s12248-021-00647-0
Autor:
Ashwni Verma, Ong Cy, Tan L, Langouet-Astrie Cj, Dhaval K. Shah, Yang Y, Schmidt Ep, Miaomiao Li, Ding Xu, Xiaoyu Zhang
RAGE, a druggable inflammatory receptor, is known to function as an oligomer but the exact oligomerization mechanism remains poorly understood. Previously we have shown that heparan sulfate (HS) plays an active role in RAGE oligomerization. To unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::982fe920a569328d121f832db55f4d57
https://doi.org/10.1101/2021.06.17.448852
https://doi.org/10.1101/2021.06.17.448852
Publikováno v:
The AAPS Journal. 23
Quantitative modeling of the subcutaneous absorption processes of protein therapeutics is challenging. Here we have proposed a “two-pore” PBPK model that is able to simultaneously characterize plasma PK of different-size protein therapeutics in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26eee693619880b405622d62297bf617
https://doi.org/10.1208/s12248-021-00588-8
https://doi.org/10.1208/s12248-021-00588-8