Combining Portable Raman Probes with Nanotubes for Theranostic Applications

Autor: Ashwinkumar A. Bhirde, Gang Liu, Albert Jin, Ramiro Iglesias-Bartolome, Alioscka A. Sousa, Richard D. Leapman, J. Silvio Gutkind, Seulki Lee, Xiaoyuan Chen

Publikováno v: Theranostics, Vol 1, Iss 1, Pp 310-321 (2011)

Recently portable Raman probes have emerged along with a variety of applications, including carbon nanotube (CNT) characterization. Aqueous dispersed CNTs have shown promise for biomedical applications such as drug/gene delivery vectors, photo-therma

Externí odkaz: https://doaj.org/article/7a2fab1a214b430e9a476b15c2853c80

The ELISA Detectability and Potency of Pegfilgrastim Decrease in Physiological Conditions: Key Roles for Aggregation and Individual Variability

Autor: Kang Chen, Meiyu Shen, Cyrus Agarabi, Meng-Jung Chiang, Patrick Lynch, Weiming Ouyang, Faruk Sheikh, Sharadrao M. Patil, Ankit B. Shah, Raymond P. Donnelly, Kurt Brorson, Hui Fang, Sarah Rogstad, Phillip Angart, David M. Frucht, Sarah J. Schrieber, Ashwinkumar A. Bhirde, Tao Xie, Kristina E. Howard

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports

PEGylated recombinant human granulocyte colony stimulating factor (pegfilgrastim) is used clinically to accelerate immune reconstitution following chemotherapy and is being pursued for biosimilar development. One challenge to overcome in pegfilgrasti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe45b4fa2041b60abacd838f0477ced2
http://link.springer.com/article/10.1038/s41598-020-59346-z

Algorithm-driven high-throughput screening of colloidal nanoparticles under simulated physiological and therapeutic conditions

Autor: Gina N. Calco, Maria A. Aronova, Serge L. Beaucage, Ashwinkumar A. Bhirde, Sivasish Sindiri

Publikováno v: Nanoscale. 9:2291-2300

Colloidal nanoparticles have shown tremendous potential as cancer drug carriers and as phototherapeutics. However, the stability of nanoparticles under physiological and phototherapeutic conditions is a daunting issue, which needs to be addressed in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23c8f06294043f8341df6984a889e35a
https://doi.org/10.1039/c6nr08579b

Structural evaluation of an amyloid fibril model using small-angle x-ray scattering

Autor: Ashwinkumar A. Bhirde, Mina Choi, Eshan Dahal, Serge L. Beaucage, Nadia Alam, Aldo Badano

Publikováno v: Physical Biology. 14:046001

Amyloid fibrils are highly structured protein aggregates associated with a wide range of diseases including Alzheimer's and Parkinson's. We report a structural investigation of an amyloid fibril model prepared from a commonly used plasma protein (bov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c99fa2bbd6751126ed0bd7c86bdbb224
https://doi.org/10.1088/1478-3975/aa776a

Morphologically-Directed Raman Spectroscopy as an Analytical Method for Subvisible Particle Characterization in Therapeutic Protein Product Quality.

Autor: Kim M; Division of Biotechnology Research and Review II, Office of Biotechnology Products, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA., Ma Y; Division of Product Quality Research, Office of Testing and Research, Office of Pharmaceutical Quality, Center for Drug Evaluation Research, U.S. Food and Drug Administration, Silver Spring, MD, USA., Srinivasan C; Division of Product Quality Research, Office of Testing and Research, Office of Pharmaceutical Quality, Center for Drug Evaluation Research, U.S. Food and Drug Administration, Silver Spring, MD, USA., O'Connor T; Division of Product Quality Research, Office of Testing and Research, Office of Pharmaceutical Quality, Center for Drug Evaluation Research, U.S. Food and Drug Administration, Silver Spring, MD, USA., Telikepalli SN; Biomolecular Measurement Division, National Institute of Standards and Technology, Gaithersburg, MD, USA., Ripple DC; Biomolecular Measurement Division, National Institute of Standards and Technology, Gaithersburg, MD, USA., Lute S; Division of Biotechnology Research and Review II, Office of Biotechnology Products, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA. Scott.Lute@fda.hhs.gov., Bhirde A; Division of Biotechnology Research and Review II, Office of Biotechnology Products, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA. Ashwinkumar.Bhirde@fda.hhs.gov.

Publikováno v: Scientific reports [Sci Rep] 2023 Nov 22; Vol. 13 (1), pp. 20473. Date of Electronic Publication: 2023 Nov 22.