Cell of Origin Links Histotype Spectrum to Immune Microenvironment Diversity in Non-small-Cell Lung Cancer Driven by Mutant Kras and Loss of Lkb1

Autor: Ashwini S. Nagaraj, Jenni Lahtela, Annabrita Hemmes, Teijo Pellinen, Sami Blom, Jennifer R. Devlin, Kaisa Salmenkivi, Olli Kallioniemi, Mikko I. Mäyränpää, Katja Närhi, Emmy W. Verschuren

Publikováno v: Cell Reports, Vol 18, Iss 3, Pp 673-684 (2017)

Lung cancers exhibit pronounced functional heterogeneity, confounding precision medicine. We studied how the cell of origin contributes to phenotypic heterogeneity following conditional expression of KrasG12D and loss of Lkb1 (Kras;Lkb1). Using proge

Externí odkaz: https://doaj.org/article/4865c03d589649f090200e998d1e2cd4

Supplementary Data from Receptor Tyrosine Kinase Signaling Networks Define Sensitivity to ERBB Inhibition and Stratify Kras-Mutant Lung Cancers

Autor: Emmy W. Verschuren, Krister Wennerberg, Mikko I. Mäyränpää, Kaisa Salmenkivi, Pipsa Saharinen, Elina A. Kiss, Swapnil Potdar, Annabrita Hemmes, Jennifer R. Devlin, Ashwini S. Nagaraj, Sarang S. Talwelkar

Supplementary text and figures

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25da8709577071f02aaeaf9cd8b88369
https://doi.org/10.1158/1535-7163.22509210.v1

Supplementary Materials and Methods from Inactivation of AMPK Leads to Attenuation of Antigen Presentation and Immune Evasion in Lung Adenocarcinoma

Autor: Tomi P. Mäkelä, Yan Yan, Benoit Viollet, Emmy W. Verschuren, Marc Foretz, Sarang S. Talwelkar, Ashwini S. Nagaraj, Kari Vaahtomeri, Iris P.L. Wong, Eva Domènech-Moreno, Sushil Tripathi, Pekka Päivinen, Yajing Gao

Supplementary Materials and Methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf7d78d002e222ae30eb969056b2dcf
https://doi.org/10.1158/1078-0432.22483148.v1

Data from Inactivation of AMPK Leads to Attenuation of Antigen Presentation and Immune Evasion in Lung Adenocarcinoma

Autor: Tomi P. Mäkelä, Yan Yan, Benoit Viollet, Emmy W. Verschuren, Marc Foretz, Sarang S. Talwelkar, Ashwini S. Nagaraj, Kari Vaahtomeri, Iris P.L. Wong, Eva Domènech-Moreno, Sushil Tripathi, Pekka Päivinen, Yajing Gao

Purpose:Mutations in STK11 (LKB1) occur in 17% of lung adenocarcinoma (LUAD) and drive a suppressive (cold) tumor immune microenvironment (TIME) and resistance to immunotherapy. The mechanisms underpinning the establishment and maintenance of a cold

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05ed9939b234523c2dcc74834050a75e
https://doi.org/10.1158/1078-0432.c.6531086.v1

Inactivation of AMPK Leads to Attenuation of Antigen Presentation and Immune Evasion in Lung Adenocarcinoma

Autor: Emmy W. Verschuren, Pekka Paivinen, Sushil Tripathi, Ashwini S. Nagaraj, Eva Domenech-Moreno, Tomi P. Mäkelä, Kari Vaahtomeri, Iris P. L. Wong, Sarang S. Talwelkar, Marc Foretz, Benoit Viollet, Yan Yan, Yajing Gao

Publikováno v: Clinical Cancer Research
Clinical Cancer Research, 2021, pp.clincanres.2049.2021. ⟨10.1158/1078-0432.CCR-21-2049⟩
Clinical Cancer Research, American Association for Cancer Research, 2021, pp.clincanres.2049.2021. ⟨10.1158/1078-0432.CCR-21-2049⟩

Purpose: Mutations in STK11 (LKB1) occur in 17% of lung adenocarcinoma (LUAD) and drive a suppressive (cold) tumor immune microenvironment (TIME) and resistance to immunotherapy. The mechanisms underpinning the establishment and maintenance of a cold

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0cf3262a0c4c81d50687c579b0bc47b
https://doi.org/10.1158/1078-0432.ccr-21-2049