Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Ashwini M. Londhe"'
Autor:
Yu Jin Hwang, Seung Jae Hyeon, Younghee Kim, Sungsu Lim, Min Young Lee, Jieun Kim, Ashwini M. Londhe, Lizaveta Gotina, Yunha Kim, Ae Nim Pae, Yong Seo Cho, Jihye Seong, Hyemyung Seo, Yun Kyung Kim, Hyunah Choo, Hoon Ryu, Sun-Joon Min
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 856-868 (2021)
The present study describes evaluation of epigenetic regulation by a small molecule as the therapeutic potential for treatment of Huntington’s disease (HD). We identified 5-allyloxy-2-(pyrrolidin-1-yl)quinoline (APQ) as a novel SETDB1/ESET inhibito
Externí odkaz:
https://doaj.org/article/53eb5263e2d44245a87e4c6d821bd071
Autor:
TaeHun Kim, Mohammad N. Morshed, Ashwini M. Londhe, Ji W. Lim, Ha E. Lee, Suengmok Cho, Sung J. Cho, Hayoung Hwang, Sang M. Lim, Jae Y. Lee, Jiyoun Lee, Ae N. Pae
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 831-846 (2021)
Small molecule modulators of mitochondrial function have been attracted much attention in recent years due to their potential therapeutic applications for neurodegenerative diseases. The mitochondrial translocator protein (TSPO) is a promising target
Externí odkaz:
https://doaj.org/article/db4d472a459a448b875a9c412c7b2955
Autor:
Ahmed Elkamhawy, Sora Paik, Hyeon Jeong Kim, Jong-Hyun Park, Ashwini M. Londhe, Kyeong Lee, Ae Nim Pae, Ki Duk Park, Eun Joo Roh
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1568-1580 (2020)
Herein, two new series of N-substituted indole-based analogues were rationally designed, synthesized via microwave heating technology, and evaluated as noteworthy MAO-B potential inhibitors. Compared to the reported indazole-based hits VI and VII, co
Externí odkaz:
https://doaj.org/article/dbd0beecfde24674a5c60b6407638e97
Autor:
Juhyeon Kim, Yoon Jung Kim, Ashwini M. Londhe, Ae Nim Pae, Hyunah Choo, Hak Joong Kim, Sun-Joon Min
Publikováno v:
Molecules, Vol 24, Iss 18, p 3234 (2019)
Here, we describe the synthesis of disubstituted pyrimidine derivatives and their biological evaluation as selective 5-HT2C agonists. To improve selectivity for 5-HT2C over other subtypes, we synthesized two series of disubstituted pyrimidines with f
Externí odkaz:
https://doaj.org/article/8e918d4918b149c5b267ed92a279987b
Autor:
Sungsu Lim, Sun-Joon Min, Yun Kyung Kim, Younghee Kim, Hyunah Choo, Lizaveta Gotina, Yu Jin Hwang, Hoon Ryu, Y. S. Kim, Ashwini M. Londhe, Jihye Seong, Min Young Lee, Ae Nim Pae, Jieun Kim, Seung Jae Hyeon, Yong Seo Cho, Hyemyung Seo
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 856-868 (2021)
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 856-868 (2021)
The present study describes evaluation of epigenetic regulation by a small molecule as the therapeutic potential for treatment of Huntington’s disease (HD). We identified 5-allyloxy-2-(pyrrolidin-1-yl)quinoline (APQ) as a novel SETDB1/ESET inhibito
Autor:
Kyeong Lee, Jong Hyun Park, Ae Nim Pae, Eun Joo Roh, Ashwini M. Londhe, Sora Paik, Ki Duk Park, Hyeon Jeong Kim, Ahmed Elkamhawy
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1568-1580 (2020)
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Herein, two new series of N-substituted indole-based analogues were rationally designed, synthesized via microwave heating technology, and evaluated as noteworthy MAO-B potential inhibitors. Compared to the reported indazole-based hits VI and VII, co
Autor:
Mohammad Morshed, Sang Min Lim, Jiyoun Lee, TaeHun Kim, Jae Y Lee, Ha E Lee, Ae N Pae, Suengmok Cho, Sung J Cho, Ashwini M. Londhe, Ji W Lim, Hayoung Hwang
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 831-846 (2021)
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 831-846 (2021)
Small molecule modulators of mitochondrial function have been attracted much attention in recent years due to their potential therapeutic applications for neurodegenerative diseases. The mitochondrial translocator protein (TSPO) is a promising target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d0fa0fabd7e8d0c5038c2ad9e5c6779
Autor:
Eun Joo Roh, Ahmed Elkamhawy, Kyung-Tae Lee, Ashwini M. Londhe, Ahmed Karam Farag, Ae Nim Pae
Publikováno v:
European Journal of Medicinal Chemistry. 141:657-675
Tyrosine kinases including LCK and FMS are involved in inflammatory disorders as well as many types of cancer. Our team has designed and synthesized thirty novel pyrimidine based inhibitors targeting LCK, classified into four different series (amides
Autor:
TaeHun Kim, Ji Eun Lee, Insun Park, Kyoung Mi Sim, Hoon Ryu, Kyoung Tai No, Seo Yun Jung, Yun Kyung Kim, Ae Nim Pae, Ashwini M. Londhe, Ambily Nath Indu Viswanath, Yu Jin Hwang, Jihye Seong, Sun-Joon Min
Publikováno v:
Journal of Computer-Aided Molecular Design. 31:877-889
ERG-associated protein with the SET domain (ESET/SET domain bifurcated 1/SETDB1/KMT1E) is a histone lysine methyltransferase (HKMT) and it preferentially tri-methylates lysine 9 of histone H3 (H3K9me3). SETDB1/ESET leads to heterochromatin condensati
Autor:
Sun-Joon Min, Juhyeon Kim, Hyunah Choo, Yoon Jung Kim, Ae Nim Pae, Ashwini M. Londhe, Hak Joong Kim
Publikováno v:
Molecules
Volume 24
Issue 18
Molecules, Vol 24, Iss 18, p 3234 (2019)
Volume 24
Issue 18
Molecules, Vol 24, Iss 18, p 3234 (2019)
Here, we describe the synthesis of disubstituted pyrimidine derivatives and their biological evaluation as selective 5-HT2C agonists. To improve selectivity for 5-HT2C over other subtypes, we synthesized two series of disubstituted pyrimidines with f