Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Ashwini L Chand"'
Autor:
Pathum Thilakasiri, Jennifer Huynh, Ashleigh R Poh, Chin Wee Tan, Tracy L Nero, Kelly Tran, Adam C Parslow, Shoukat Afshar‐Sterle, David Baloyan, Natalie J Hannan, Michael Buchert, Andrew Mark Scott, Michael DW Griffin, Frederic Hollande, Michael W Parker, Tracy L Putoczki, Matthias Ernst, Ashwini L Chand
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 4, Pp n/a-n/a (2019)
Abstract Excessive signaling through gp130, the shared receptor for the interleukin (IL)6 family of cytokines, is a common hallmark in solid malignancies and promotes their progression. Here, we established the in vivo utility of bazedoxifene, a ster
Externí odkaz:
https://doaj.org/article/f3ddb855617e4e378193d6b8beddb2bb
Autor:
Rhynelle S. Dmello, Michelle Palmieri, Pathum S. Thilakasiri, Larissa Doughty, Tracy L. Nero, Ashleigh R. Poh, Sarah Q. To, Erinna F. Lee, W. Douglas Fairlie, Lisa Mielke, Michael W. Parker, Ivan K. H. Poon, Eduard Batlle, Matthias Ernst, Ashwini L. Chand
Publikováno v:
Cell Death and Disease, Vol 15, Iss 4, Pp 1-13 (2024)
Abstract Excessive STAT3 signalling via gp130, the shared receptor subunit for IL-6 and IL-11, contributes to disease progression and poor survival outcomes in patients with colorectal cancer. Here, we provide evidence that bazedoxifene inhibits tumo
Externí odkaz:
https://doaj.org/article/edd38efeaa4746be83b35dd07210b0bf
Autor:
Ashwini L Chand, Dhilushi D Wijayakumara, Kevin C Knower, Kerrie A Herridge, Tamara L Howard, Kyren A Lazarus, Colin D Clyne
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31593 (2012)
BackgroundLiver Receptor Homolog 1 (LRH-1, NR5A2) is an orphan nuclear receptor that is over-expressed in cancers in tissues such as the breast, colon and pancreas. LRH-1 plays important roles in embryonic development, steroidogenesis and cholesterol
Externí odkaz:
https://doaj.org/article/72877468662c4a26bf6320f69dff57d8
Autor:
Matthias Ernst, Ashwini L. Chand, Frederick Masson, Louis Boon, Moritz F. Eissmann, Pathum Thilakasiri, Adam C. Parslow, David S. Williams, Lokman Pang, Mariah Alorro, Shoukat Afshar-Sterle, Megan O'Brien, Wei Shi, David Chisanga, David Baloyan, Jennifer Huynh
IL11 is a member of the IL6 family of cytokines and signals through its cognate receptor subunits, IL11RA and glycoprotein 130 (GP130), to elicit biological responses via the JAK/STAT signaling pathway. IL11 contributes to cancer progression by promo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59d0223f3118b1931ca3497342246e47
https://doi.org/10.1158/2326-6066.c.6550444.v1
https://doi.org/10.1158/2326-6066.c.6550444.v1
Autor:
Matthias Ernst, Robert J.J. O'Donoghue, Fiona J. Pixley, Tracy L. Putoczki, Clifford A. Lowell, Megan O'Brien, Lachlan Whitehead, Michael W. Murrey, Louis Boon, David Baloyan, Ashwini L. Chand, Moritz F. Eissmann, Amy R. Dwyer, Ashleigh R. Poh
Increased HCK activity in BMDMs supports tumor cell invasion in vitro.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d0176964ef16bdad891da122661b61
https://doi.org/10.1158/2326-6066.22542897.v1
https://doi.org/10.1158/2326-6066.22542897.v1
Autor:
Matthias Ernst, Robert J.J. O'Donoghue, Fiona J. Pixley, Tracy L. Putoczki, Clifford A. Lowell, Megan O'Brien, Lachlan Whitehead, Michael W. Murrey, Louis Boon, David Baloyan, Ashwini L. Chand, Moritz F. Eissmann, Amy R. Dwyer, Ashleigh R. Poh
Persistent activation of the latent transcription factor STAT3 is observed in gastric tumor epithelial and immune cells and is associated with a poor patient prognosis. Although targeting STAT3-activating upstream kinases offers therapeutically viabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a55fcba6c2fa63a18d36a4da65f2571
https://doi.org/10.1158/2326-6066.c.6550074.v1
https://doi.org/10.1158/2326-6066.c.6550074.v1
Autor:
Matthias Ernst, Robert J.J. O'Donoghue, Fiona J. Pixley, Tracy L. Putoczki, Clifford A. Lowell, Megan O'Brien, Lachlan Whitehead, Michael W. Murrey, Louis Boon, David Baloyan, Ashwini L. Chand, Moritz F. Eissmann, Amy R. Dwyer, Ashleigh R. Poh
Constitutive HCK activity in bone marrow-derived cells enhances STAT3 activation in tumors and tumor-associated macrophages.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a74ec4c16f52870e618866ba0774ef
https://doi.org/10.1158/2326-6066.22542900.v1
https://doi.org/10.1158/2326-6066.22542900.v1
Autor:
Matthias Ernst, Robert J.J. O'Donoghue, Fiona J. Pixley, Tracy L. Putoczki, Clifford A. Lowell, Megan O'Brien, Lachlan Whitehead, Michael W. Murrey, Louis Boon, David Baloyan, Ashwini L. Chand, Moritz F. Eissmann, Amy R. Dwyer, Ashleigh R. Poh
Increased expression of genes associated with alternative macrophage polarization confers a poorer overall survival in human intestinal-type gastric cancer patients.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c074531e7422bd9f135060ddedca8ae
https://doi.org/10.1158/2326-6066.22542894
https://doi.org/10.1158/2326-6066.22542894
Autor:
Matthias Ernst, Ashwini L. Chand, Frederick Masson, Louis Boon, Moritz F. Eissmann, Pathum Thilakasiri, Adam C. Parslow, David S. Williams, Lokman Pang, Mariah Alorro, Shoukat Afshar-Sterle, Megan O'Brien, Wei Shi, David Chisanga, David Baloyan, Jennifer Huynh
Supplementary Figure 1. Gating strategy and representative flow cytometric plots of MC38 tumors from WT and Il11ra-/- hosts. Supplementary Figure 2. IL-11 has no effect on tumor-infiltrating immune cells in MC38 and CT26 tumors from WT and Il11ra-/-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b6607bcf5c77a347b942fb367b71597
https://doi.org/10.1158/2326-6066.22543882
https://doi.org/10.1158/2326-6066.22543882
Autor:
Matthias Ernst, Robert J.J. O'Donoghue, Fiona J. Pixley, Tracy L. Putoczki, Clifford A. Lowell, Megan O'Brien, Lachlan Whitehead, Michael W. Murrey, Louis Boon, David Baloyan, Ashwini L. Chand, Moritz F. Eissmann, Amy R. Dwyer, Ashleigh R. Poh
Supplementary Table 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3304b5be5c819c04cdad4eb8b5df768
https://doi.org/10.1158/2326-6066.22542888
https://doi.org/10.1158/2326-6066.22542888