Výsledky vyhledávání - "Ashwini K. Banala"

High Affinity Dopamine D3 Receptor (D3R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D3R Knockout Mice

Autor: Caitlin Burzynski, Rana Rais, Comfort A. Boateng, Amy Hauck Newman, Oluyomi M. Bakare, Thomas M. Keck, Elie Pommier, Jonathan A. Javitch, Zheng-Xiong Xi, Jia Zhan, Barbara S. Slusher, Prashant Donthamsetti, Ashwini K. Banala

Publikováno v: Journal of Medicinal Chemistry

The dopamine D3 receptor (D3R) is a promising target for the development of pharmacotherapeutics to treat substance use disorders. Several D3R-selective antagonists are effective in animal models of drug abuse, especially in models of relapse. Nevert

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34dbb10e40377b8965f9aed3b6766a60
https://doi.org/10.1021/acs.jmedchem.5b00776

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Using click chemistry toward novel 1,2,3-triazole-linked dopamine D3 receptor ligands

Autor: Ashwini K. Banala, Martin H. Moore, Rana Rais, Barbara S. Slusher, Rachel D. Slack, Amy Hauck Newman, Caitlin Burzynski, Jeffrey R. Deschamps, Oluyomi M. Okunola-Bakare, Thomas M. Keck, Alessandro Bonifazi

Publikováno v: Bioorganic & Medicinal Chemistry. 23:4000-4012

The dopamine D3 receptor (D3R) is a target of pharmacotherapeutic interest in a variety of neurological disorders including schizophrenia, Parkinson's disease, restless leg syndrome, and drug addiction. A common molecular template used in the develop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d81a04d310bf91ce40921b649007718c
https://doi.org/10.1016/j.bmc.2015.01.017

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Design and Synthesis of 1-(3-(Dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile (Citalopram) Analogues as Novel Probes for the Serotonin Transporter S1 and S2 Binding Sites

Autor: Ashwini K. Banala, Peng Zhang, Theresa A. Kopajtic, Per Plenge, George Cyriac, Amy Hauck Newman, Claus J. Loland, Jonathan L. Katz

Publikováno v: Journal of Medicinal Chemistry. 56:9709-9724

The serotonin transporter (SERT) is the primary target for antidepressant drugs. The existence of a high affinity primary orthosteric binding site (S1) and a low affinity secondary site (S2) has been described, and their relation to antidepressant ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1ecf2ade7d007a7e57e35e96bbea336
https://doi.org/10.1021/jm4014136

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A Single Glycine in Extracellular Loop 1 Is the Critical Determinant for Pharmacological Specificity of Dopamine D2 and D3 Receptors

Autor: Thomas Roux, Eric Trinquet, Thijs Beuming, Mayako Michino, Ashwini K. Banala, Prashant Donthamsetti, Jonathan A. Javitch, Lei Shi, Lihua Duan, Yang Han, Amy Hauck Newman

Publikováno v: Molecular Pharmacology. 84:854-864

Subtype-selective agents for the dopamine D3 receptor (D3R) have been considered as potential medications for drug addiction and other neuropsychiatric disorders. Medicinal chemistry efforts have led to the discovery of 4-phenylpiperazine derivatives

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b99704e40989ea7ecd07f159083acaf
https://doi.org/10.1124/mol.113.087833

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Molecular Determinants of Selectivity and Efficacy at the Dopamine D3 Receptor

Autor: Katherine Pongetti, Prashant Donthamsetti, Robert R. Luedtke, Ashwini K. Banala, Lei Shi, Amy Hauck Newman, Thijs Beuming, Alex LaBounty, Jonathan A. Javitch, Benjamin A. Levy, Mayako Michino, Jianjing Cao

Publikováno v: Journal of Medicinal Chemistry. 55:6689-6699

The dopamine D3 receptor (D3R) has been implicated in substance abuse and other neuropsychiatric disorders. The high sequence homology between the D3R and D2R, especially within the orthosteric binding site (OBS) that binds dopamine, has made the dev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::684ed48441eab67236c97101226a520d
https://doi.org/10.1021/jm300482h

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Investigation of the binding and functional properties of extended length D3 dopamine receptor-selective antagonists

Autor: Christopher D. Sibley, Vivek Kumar, Amy Hauck Newman, Rebecca A. Roof, Noel M. Paul, R. Benjamin Free, Trevor Doyle, Amy E. Moritz, Ashwini K. Banala, Cheryse A. Furman, David R. Sibley, Brittney N. Miller

Publikováno v: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 25(9)

The D3 dopamine receptor represents an important target in drug addiction in that reducing receptor activity may attenuate the self-administration of drugs and/or disrupt drug or cue-induced relapse. Medicinal chemistry efforts have led to the develo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b105ef69370fab9a77d418f9c1731fa0
https://pubmed.ncbi.nlm.nih.gov/25583363

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Chiral Resolution and Serendipitous Fluorination Reaction for the Selective Dopamine D3 Receptor Antagonist BAK2-66

Autor: Jianjing Cao, Vivek Kumar, Amy Hauck Newman, Ashwini K. Banala, Alessandro Bonifazi, Thomas M. Keck, Erick G. Garcia, Jeffery R. Deschamps

The improved chiral synthesis of the selective dopamine D3 receptor (D3R) antagonist (R)-N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)-3-hydroxybutyl)1H-indole-2-carboxamide (( R )-PG648) is described. The same chiral secondary alcohol intermediate was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23a329ba834b5c3e0ab54d921eb9f4de
https://europepmc.org/articles/PMC4060923/

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