Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Ashwini, Jambhekar"'
Autor:
Jia-Yun Chen, Clemens Hug, José Reyes, Chengzhe Tian, Luca Gerosa, Fabian Fröhlich, Bas Ponsioen, Hugo J.G. Snippert, Sabrina L. Spencer, Ashwini Jambhekar, Peter K. Sorger, Galit Lahav
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112252- (2023)
Summary: Oncogene-induced senescence is a phenomenon in which aberrant oncogene expression causes non-transformed cells to enter a non-proliferative state. Cells undergoing oncogenic induction display phenotypic heterogeneity, with some cells senesci
Externí odkaz:
https://doaj.org/article/36dd9f1bb081478bb61988811e5931cb
Autor:
Alba Jiménez, Dan Lu, Marian Kalocsay, Matthew J Berberich, Petra Balbi, Ashwini Jambhekar, Galit Lahav
Publikováno v:
Molecular Systems Biology, Vol 18, Iss 3, Pp 1-18 (2022)
Abstract The cell stress‐responsive transcription factor p53 influences the expression of its target genes and subsequent cellular responses based in part on its dynamics (changes in level over time). The mechanisms decoding p53 dynamics into subse
Externí odkaz:
https://doaj.org/article/c1c9a8215f07411f822a4bb11aeab073
Autor:
Jacob Stewart-Ornstein, Yoshiko Iwamoto, Miles A. Miller, Mark A. Prytyskach, Stephane Ferretti, Philipp Holzer, Joerg Kallen, Pascal Furet, Ashwini Jambhekar, William C. Forrester, Ralph Weissleder, Galit Lahav
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
p53 mediates the response to irradiation, however, tissues with similar levels of p53 have different radiation sensitivities. Here, the authors show that the in vivo p53 dynamics varies in these tissues after radiation, and the use of Mdm2 inhibitor
Externí odkaz:
https://doaj.org/article/ec4f9099e0ec49f6920b6fbb19143619
Autor:
Barry M. Zee, Kamrine E. Poels, Cong-Hui Yao, Kimihito C. Kawabata, Gongwei Wu, Cihangir Duy, William D. Jacobus, Elizabeth Senior, Jennifer E. Endress, Ashwini Jambhekar, Scott B. Lovitch, Jiexian Ma, Abhinav Dhall, Isaac S. Harris, M. Andres Blanco, David B. Sykes, Jonathan D. Licht, David M. Weinstock, Ari Melnick, Marcia C. Haigis, Franziska Michor, Yang Shi
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102651- (2021)
Summary: A hallmark of acute myeloid leukemia (AML) is the inability of self-renewing malignant cells to mature into a non-dividing terminally differentiated state. This differentiation block has been linked to dysregulation of multiple cellular proc
Externí odkaz:
https://doaj.org/article/df9a6accf7904e598158db5f5e73b10a
Autor:
Michael Tsabar, Caroline S. Mock, Veena Venkatachalam, Jose Reyes, Kyle W. Karhohs, Trudy G. Oliver, Aviv Regev, Ashwini Jambhekar, Galit Lahav
Publikováno v:
Cell Reports, Vol 32, Iss 5, Pp 107995- (2020)
Summary: Cellular responses to stimuli can evolve over time, resulting in distinct early and late phases in response to a single signal. DNA damage induces a complex response that is largely orchestrated by the transcription factor p53, whose dynamic
Externí odkaz:
https://doaj.org/article/49f723eeb186475d9897e492d44ece48
Autor:
Sungjin Park, Randall D. Dahn, Elif Kurt, Adrien Presle, Kathryn VandenHeuvel, Cara Moravec, Ashwini Jambhekar, Olushola Olukoga, Jason Shepherd, Arnaud Echard, Michael Blower, Ahna Renee Skop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d010f598e2701b62f584af653ad8a40c
https://doi.org/10.2139/ssrn.4318824
https://doi.org/10.2139/ssrn.4318824
Autor:
Sungjin Park, Randall D. Dahn, Elif Kurt, Adrien Presle, Kathryn VanDenHeuvel, Cara Moravec, Ashwini Jambhekar, Olushola Olukoga, Jason Shepherd, Arnaud Echard, Michael Blower, Ahna R. Skop
The midbody (MB) is a transient structure at the spindle midzone that is required for cytokinesis, the terminal stage of cell division. Long ignored as a vestigial remnant of cytokinesis, we now know MBs are released post-abscission as extracellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d662022e46c164856adf443613482404
https://doi.org/10.1101/2022.11.01.514698
https://doi.org/10.1101/2022.11.01.514698
Stem cells integrate information from multiple signals in their environment to make fate decisions. It is unclear how signal integration is linked to the coordinated activation of a target fate program and simultaneous inactivation of competing fates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::155b7c6f354170131040c9854581c68a
https://doi.org/10.1101/2022.10.10.511605
https://doi.org/10.1101/2022.10.10.511605
Autor:
Saravanapriah Nadarajan, Firaz Mohideen, Yonatan B Tzur, Nuria Ferrandiz, Oliver Crawley, Alex Montoya, Peter Faull, Ambrosius P Snijders, Pedro R Cutillas, Ashwini Jambhekar, Michael D Blower, Enrique Martinez-Perez, J Wade Harper, Monica P Colaiacovo
Publikováno v:
eLife, Vol 5 (2016)
Asymmetric disassembly of the synaptonemal complex (SC) is crucial for proper meiotic chromosome segregation. However, the signaling mechanisms that directly regulate this process are poorly understood. Here we show that the mammalian Rho GEF homolog
Externí odkaz:
https://doaj.org/article/4df71421871c44c4a4879464b70529bc
Autor:
Nils Blüthgen, Galit Lahav, Alba Jiménez, Adrián E. Granada, Ashwini Jambhekar, Jacob Stewart-Ornstein, Simone Reber
Publikováno v:
Molecular Biology of the Cell
DNA-damaging chemotherapeutics are widely used in cancer treatments, but for solid tumors they often leave a residual tumor-cell population. Here we investigated how cellular states might affect the response of individual cells in a clonal population
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c65b48bd7e0d0a7f20604bc312353e82
https://doi.org/10.1091/mbc.e19-09-0515
https://doi.org/10.1091/mbc.e19-09-0515