Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ashwin U. Rao"'
Autor:
Ravi P. Nargund, Li-Kang Zhang, Xiaoxin Yang, Hongchen Qiu, Anandan Palani, Xianhai Huang, Craig C. Correll, Robert G. Aslanian, Wei Zhou, Ashwin U. Rao, Alexei V. Buevich, Charles G. Garlisi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:5344-5348
New synthetic methods were developed for the preparation of 2,3,6-trisubstituted 1-oxo-1,2-dihydroisoquinolines as CRTh2 antagonists. The isoquinolinone core could be constructed before the introduction of substitution groups or synthesized through a
Autor:
Xianhai Huang, Robert G. Aslanian, Xiao Chen, Zhidan Liu, Anandan Palani, Madhu Chintala, Haiqun Tang, Jing Su, Jun Qin, Xiaohong Zhu, Scott Greenfeder, Mckittrick Brian A, Ashwin U. Rao, Margaret van Heek, Wei Zhou, Ying Huang, Dong Xiao, Sylvia J. Degrado
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:854-858
Based on in house screening lead compound 1 for the NAR project, SAR studies have been focused on the modification of the C2 ethers of the pyrimidinedione core structure. In this effort, an unpredictable SAR trend was overcome in the alkyl ether and
Autor:
Fang Tian, Prashant Trivedi, Xianhai Huang, Dong Xiao, Robert G. Aslanian, Wei Zhou, Anandan Palani, Ashwin U. Rao, James Fossetta, Dan Lundell
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:1068-1072
Facile synthesis of two new series of tetracyclic azepine and oxazocine analogs is described. These analogs were evaluated for their potential as MAPKAP-K2 (MK2) inhibitors and several were found to be potent at inhibiting MK2 with a non-ATP competit
Autor:
Anandan Palani, Ashwin U. Rao, Xiao Chen, Xianhai Huang, Jing Su, Haiqun Tang, Ying Huang, Jun Qin, Dong Xiao, Sylvia Degrado, Michael Sofolarides, Xiaohong Zhu, Zhidan Liu, Brian McKittrick, Wei Zhou, Robert Aslanian, William J. Greenlee, Mary Senior, Boonlert Cheewatrakoolpong, Hongtao Zhang, Constance Farley, John Cook, Stan Kurowski, Qiu Li, Margaret van Heek, Gangfeng Wang, Yunsheng Hsieh, Fangbiao Li, Scott Greenfeder, Madhu Chintala
Publikováno v:
ACS Medicinal Chemistry Letters. 3:63-68
Structure-guided optimization of a series of C-5 alkyl substituents led to the discovery of a potent nicotinic acid receptor agonist SCH 900271 (33) with an EC50 of 2 nM in the hu-GPR109a assay. Compound 33 demonstrated good oral bioavailability in a
Autor:
Shirley M. Williams, Robert G. Aslanian, Christopher Sondey, Sylvia J. Degrado, Ning Shao, Mary Senior, Li Wang, Shuqin Zheng, Joyce J. Hwa, Robert E. West, Ren-Long Wu, Ashwin U. Rao, Anandan Palani, Bhuneshwari Patel, Mckittrick Brian A, Tin-Yau Chan
Publikováno v:
ACS Medicinal Chemistry Letters. 3:198-202
A series of novel 2-piperidinopiperidine thiadiazoles were synthesized and evaluated as new leads of histamine H3 receptor antagonists. The 4-(5-([1,4'-bipiperidin]-1'-yl)-1,3,4-thiadiazol-2-yl)-2-(pyridin-2-yl)morpholine (5u) displayed excellent pot
Autor:
Sylvia J. Degrado, Ning Shao, Fang Tian, Xiao Chen, Michael Sofolarides, Xiaohong Zhu, Dong Xiao, Daniel Lundell, Ashwin U. Rao, James Fossetta, Anandan Palani, Prashant Trivedi, Robert G. Aslanian
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(15)
A unified strategy was conceived and implemented to deliver conformationally constrained anilides based on their preferred cis-amide conformers. The imidazole/triazole mimicing amide bonds were designed, building upon an earlier discovery of a novel
Autor:
Ashwin U. Rao, et al. et al.
Publikováno v:
ChemInform. 43
Several tetracyclic azepine and oxazocine pharmacophores are synthesized which show potent inhibition against MK2 with a non-ATP competitive binding mode as well as inhibition of HSP27 phosphorylation in THP-1 cells.
Autor:
Xianhai Huang, Anandan Palani, John Cook, Stan Kurowski, Constance Farley, Jun Qin, Madhu Chintala, Xiaohong Zhu, Margaret van Heek, Ying Huang, Hongtao Zhang, Boonlert Cheewatrakoolpong, Sylvia J. Degrado, Ashwin U. Rao, Scott Greenfeder, Fangbiao Li, Qiu Li, Dong Xiao, Xiao Chen, Ganfeng Wang, Yunsheng Hsieh, Zhidan Liu, Robert G. Aslanian
Nicotinic acid has been used clinically for decades to control serum lipoproteins. Nicotinic acid lowers very low-density lipoprotein (VLDL)-cholesterol, low-density lipoprotein (LDL)-cholesterol, and lipoprotein-a (LPa), and it is also effective in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed5966656f2ea3f783fe9ed9e9ab050
https://europepmc.org/articles/PMC4017979/
https://europepmc.org/articles/PMC4017979/
Autor:
Joyce J. Hwa, Jean E. Lachowicz, Robert G. Aslanian, Xiao Chen, Shirley M. Williams, Robert E. West, Anandan Palani, Ren-Long Wu, Ashwin U. Rao, Ying Huang, Christopher Sondey
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(21)
A series of 2-(1,4′-bipiperidine-1′-yl)thiazolopyridines was synthesized and evaluated as a new lead of non-imidazole histamine H3 receptor antagonists. Introduction of diversity at the 6-position of the pyridine ring was designed to enhance in v