Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Ashwin Narain"'
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100949- (2021)
Summary: Targeted protein degradation using degrons, such as the mini-Auxin-inducible degron (mAID), has an advantage over genetic silencing/knockout. However, the efficiency of sgRNA, homologous recombination, tedious expansion, and screening single
Externí odkaz:
https://doaj.org/article/eabd39a47e3e4e508f16a6a2b0613cc0
Autor:
Stephanie Heinzlmeir, Bikash Adhikari, Bernhard Kuster, Ashwin Narain, Pranjali Bhandare, Jessica Denise Schwarz, Lars Schönemann, Mathias Diebold, Nevenka Dudvarski Stankovic, Julia Hofstetter, Lorenz Eing, Martin Schröder, Stefan Knapp, Elmar Wolf, Apoorva Baluapuri, Christoph A. Sotriffer, Jelena Bozilovic, Marek Wanior, Andreas Schlosser, Markus Vogt
Publikováno v:
Nature Chemical Biology
Nature chemical biology
Nature chemical biology
The mitotic kinase AURORA-A is essential for cell cycle progression and is considered a priority cancer target. Although the catalytic activity of AURORA-A is essential for its mitotic function, recent reports indicate an additional non-catalytic fun
Autor:
Andreas Schlosser, Martin Eilers, Bikash Adhikari, Simone Backes, Pranjali Bhandare, Elmar Wolf, Apoorva Baluapuri, Florian Erhard, Ashwin Narain, Lars Dölken
Publikováno v:
Molecular Cell
Summary SPT6 is a histone chaperone that tightly binds RNA polymerase II (RNAPII) during transcription elongation. However, its primary role in transcription is uncertain. We used targeted protein degradation to rapidly deplete SPT6 in human cells an
Publikováno v:
Unravelling Cancer Signaling Pathways: A Multidisciplinary Approach ISBN: 9789813298156
Nanotechnology, which is defined as the science behind the structures within the size range of 1–100 nm, potentially holds the key to treat several chronic diseases such as cardiovascular diseases, respiratory diseases and cancer. Nanoscale structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fac1ede6cfc2303969a72660a3a90c90
https://doi.org/10.1007/978-981-32-9816-3_16
https://doi.org/10.1007/978-981-32-9816-3_16
Publikováno v:
Nanomedicine (London, England). 12(21)
Cell membrane coated nanoparticles (NPs) is a biomimetic strategy developed to engineer therapeutic devices consisting of a NP core coated with membrane derived from natural cells such as erythrocytes, white blood cells, cancer cells, stem cells, pla
Autor:
Robert Düster, Martin Eilers, Bikash Adhikari, Shuang-Yan Wang, Ashwin Narain, Elmar Wolf, Susanne Walz, Armin Wiegering, Peter Gallant, Patrick Cramer, Pranjali Bhandare, Andreas Schlosser, Seychelle M. Vos, Julia Hofstetter, Theresa Endres, Apoorva Baluapuri, Hans Michael Maric, Nevenka Dudvarski Stankovic, Matthias Geyer, Jens T. Vanselow, Jessica Denise Schwarz, Lisa Anna Jung, Markus Vogt
Publikováno v:
Molecular Cell
Summary The MYC oncoprotein binds to promoter-proximal regions of virtually all transcribed genes and enhances RNA polymerase II (Pol II) function, but its precise mode of action is poorly understood. Using mass spectrometry of both MYC and Pol II co
Autor:
Kakoli Bose, Pradip Chaudhari
Unravelling the intricate cell signalling networks and their significance in cancer poses major intellectual challenge. Keeping this in mind, the book aims at understanding the mechanism of action of different proteins and their complexes in the canc