Ex Vivo T Cell Cytokine Expression Predicts Survival in Patients with Severe Alcoholic Hepatitis

Autor: Ashwin D. Dhanda, Euan Yates, Lauren P. Schewitz-Bowers, Philippa J. Lait, Richard W. J. Lee, Matthew E. Cramp

Publikováno v: Gut and Liver, Vol 14, Iss 2, Pp 265-268 (2020)

Alcoholic hepatitis (AH) is an acute inflammatory liver condition with high early mortality rate. Steroids improve short-term survival but nonresponders have the worst outcomes. There is a clinical need to identify these high-risk individuals at the

Externí odkaz: https://doaj.org/article/a7eb6eed954446afae71a4eee6965b29

Mental Imagery to Reduce Alcohol-related harm in patients with alcohol dependence and alcohol-related liver damaGE: the MIRAGE pilot trial protocol

Autor: Ashwin D Dhanda, Hannah Allende, Victoria Allgar, Jackie Andrade, Matthew Peter Bailey, Lynne Callaghan, Laura Cocking, Elizabeth Goodwin, Annie Hawton, Christopher Hayward, Ben Hudson, Alison Jeffery, Angela King, Victoria Lavers, Joe Lomax, C Anne McCune, Richard Parker, Christopher Rollinson, Jonny Wilks, E Siobhan Creanor

Publikováno v: BMJ Open. 12:e060498

Introduction In the UK, alcohol use is the main driver of chronic liver disease and each year results in over 1 million unplanned hospital admissions and over 25 000 deaths from alcohol-related liver disease (ArLD). The only effective treatment to pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::266fad22baa964934672fe46542fca7e
https://doi.org/10.1136/bmjopen-2021-060498

Glucocorticoid treatment in patients with newly diagnosed immune thrombocytopenia switches CD14

Autor: Emily L, Williams, Madeleine L, Stimpson, Philippa J P, Lait, Lauren P, Schewitz-Bowers, Lauren V, Jones, Ashwin D, Dhanda, Richard W J, Lee, Charlotte A, Bradbury

Publikováno v: British journal of haematologyReferences. 192(2)

Immune thrombocytopenia (ITP) is thought to result from an aberrant adaptive autoimmune response, involving autoantibodies, B and T lymphocytes, directed at platelets and megakaryocytes. Previous reports have demonstrated skewed CD4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::05915aea67e30b3afebf3f59cd618367
https://pubmed.ncbi.nlm.nih.gov/33338258

Infection does not increase long-term mortality in patients with acute severe alcoholic hepatitis treated with corticosteroids.

Autor: Dhanda AD; Ashwin D Dhanda, Matthew E Cramp, Institute of Translational and Stratified Medicine, Plymouth University Peninsula Schools of Medicine and Dentistry, Plymouth PL6 8BU, United Kingdom., Sinha A; Ashwin D Dhanda, Matthew E Cramp, Institute of Translational and Stratified Medicine, Plymouth University Peninsula Schools of Medicine and Dentistry, Plymouth PL6 8BU, United Kingdom., Hunt V; Ashwin D Dhanda, Matthew E Cramp, Institute of Translational and Stratified Medicine, Plymouth University Peninsula Schools of Medicine and Dentistry, Plymouth PL6 8BU, United Kingdom., Saleem S; Ashwin D Dhanda, Matthew E Cramp, Institute of Translational and Stratified Medicine, Plymouth University Peninsula Schools of Medicine and Dentistry, Plymouth PL6 8BU, United Kingdom., Cramp ME; Ashwin D Dhanda, Matthew E Cramp, Institute of Translational and Stratified Medicine, Plymouth University Peninsula Schools of Medicine and Dentistry, Plymouth PL6 8BU, United Kingdom., Collins PL; Ashwin D Dhanda, Matthew E Cramp, Institute of Translational and Stratified Medicine, Plymouth University Peninsula Schools of Medicine and Dentistry, Plymouth PL6 8BU, United Kingdom.

Publikováno v: World journal of gastroenterology [World J Gastroenterol] 2017 Mar 21; Vol. 23 (11), pp. 2052-2059.

Is liver biopsy necessary in the management of alcoholic hepatitis?

Autor: Dhanda AD; Ashwin D Dhanda, Peter L Collins, C Anne McCune, Department of Liver Medicine, University Hospitals Bristol NHS Foundation Trust, Bristol BS2 8HW, United Kingdom., Collins PL, McCune CA

Publikováno v: World journal of gastroenterology [World J Gastroenterol] 2013 Nov 28; Vol. 19 (44), pp. 7825-9.