Výsledky vyhledávání - "Ashwin C Murthy"

Akademický článek

Impact of Kidney Function on the Blood Proteome and on Protein Cardiovascular Risk Biomarkers in Patients With Stable Coronary Heart Disease

Autor: Joseph Yang, Edward N. Brody, Ashwin C. Murthy, Robert E. Mehler, Sophie J. Weiss, Robert K. DeLisle, Rachel Ostroff, Stephen A. Williams, Peter Ganz

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 15 (2020)

Background Chronic kidney disease (CKD) confers increased cardiovascular risk, not fully explained by traditional factors. Proteins regulate biological processes and inform the risk of diseases. Thus, in 938 patients with stable coronary heart diseas

Externí odkaz: https://doaj.org/article/f83d4b28db5b4ae185992624b9f7d669

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Akademický článek

42855 A Phenomics Approach to the Categorization and Refinement of Heart Failure

Autor: Nosheen Reza, William Bone, Pankhuri Singhal, Anurag Verma, Ashwin C. Murthy, Srinivas Denduluri, Srinath Adusumalli, Macrylyn D. Ritchie, Thomas P. Cappola

Publikováno v: Journal of Clinical and Translational Science, Vol 5, Pp 46-47 (2021)

ABSTRACT IMPACT: Measuring and analyzing qualitative and quantitative traits using phenomics approaches will yield previously unrecognized heart failure subphenotypes and has the potential to improve our knowledge of heart failure pathophysiology, id

Externí odkaz: https://doaj.org/article/e47ed6cb7e1a45c0ad940ab1be3dcce9

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Proteomic cardiovascular risk assessment in chronic kidney disease

Publikováno v: European Heart Journal.

Aims Chronic kidney disease (CKD) is widely prevalent and independently increases cardiovascular risk. Cardiovascular risk prediction tools derived in the general population perform poorly in CKD. Through large-scale proteomics discovery, this study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::59c29b694b223f2b0aa74f2bfbb808aa
https://doi.org/10.1093/eurheartj/ehad115

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Mechanisms of Sodium-Glucose Cotransporter 2 Inhibition: Insights From Large-Scale Proteomics

Autor: Yong Ho Lee, Rachel Ostroff, Peter Ganz, Naveed Sattar, Ele Ferrannini, Stephen A. Williams, Sophie Weiss, Elza Muscelli, Ashwin C. Murthy

Publikováno v: Diabetes care. 43(9)

OBJECTIVE To assess the effects of empagliflozin, a selective sodium–glucose cotransporter 2 (SGLT2) inhibitor, on broad biological systems through proteomics. RESEARCH DESIGN AND METHODS Aptamer-based proteomics was used to quantify 3,713 proteins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0042efbc23aff22596a5ba12059c39a1
https://pubmed.ncbi.nlm.nih.gov/32527800

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42855 A Phenomics Approach to the Categorization and Refinement of Heart Failure

Autor: William P. Bone, Anurag Verma, Ashwin C. Murthy, Srinath Adusumalli, Macrylyn D. Ritchie, Srinivas Denduluri, Nosheen Reza, Thomas P. Cappola, Pankhuri Singhal

Publikováno v: Journal of Clinical and Translational Science. 5:46-47

IMPACT: Measuring and analyzing qualitative and quantitative traits using phenomics approaches will yield previously unrecognized heart failure subphenotypes and has the potential to improve our knowledge of heart failure pathophysiology, identify no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f443377794a39276757fbd8511102c4
https://doi.org/10.1017/cts.2021.524

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Improving Assessment of Drug Safety Through Proteomics: Early Detection and Mechanistic Characterization of the Unforeseen Harmful Effects of Torcetrapib

Autor: Craig L. Hyde, Rachel Ostroff, Peter Ganz, Stephen A. Williams, Robert Kirk DeLisle, Mark R. Segal, Ashwin C. Murthy, Anders Mälarstig, Sophie Weiss

Publikováno v: Circulation, vol 137, iss 10

Background: Early detection of adverse effects of novel therapies and understanding of their mechanisms could improve the safety and efficiency of drug development. We have retrospectively applied large-scale proteomics to blood samples from ILLUMINA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::649d303bf8aaab84972f48df7f2ff28b
https://escholarship.org/uc/item/6593b5zh

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VARIATION IN EMERGENCY DEPARTMENT PROVIDER ORDERING, TIME TO DISCHARGE, AND OUTCOMES IN ANATOMIC VERSUS FUNCTIONAL STRESS TESTING FOR RISK STRATIFICATION OF PATIENTS PRESENTING WITH CHEST DISCOMFORT

Autor: Mahesh K Vidula, Ruth Tamrat, Dipika Gopal, Vivek Kulkarni, Shan Davis, Victor A. Ferrari, Ashwin C. Murthy, Paco E Bravo, Dinesh Jagasia, Srinath Adusumalli, David Lambert, Sheela Krishnan, Frank E. Silvestry, Daniel M. Kolansky, Senthil Selvaraj

Publikováno v: Journal of the American College of Cardiology. 73:1556

Anatomic testing with coronary computed tomography angiography (CCTA) and functional stress testing are both appropriate first-line testing for evaluation of low to intermediate risk chest discomfort in the emergency department (ED). Real world data

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ffc8c365f92e3ef9a34d2c3ff7f14e5f
https://doi.org/10.1016/s0735-1097(19)32162-x

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LOW RATE OF IMPLEMENTATION OF PREVENTIVE MEDICAL THERAPY FOR NON-OBSTRUCTIVE CORONARY ARTERY DISEASE FOUND ON CORONARY COMPUTED TOMOGRAPHY ANGIOGRAPHY PERFORMED IN THE EMERGENCY DEPARTMENT

Autor: Mahesh K Vidula, Senthil Selvaraj, Sheela Krishnan, Shan Davis, Ashwin C. Murthy, Dipika Gopal, Victor A. Ferrari, Srinath Adusumalli, Dinesh Jagasia, Vivek Kulkarni, Ruth Tamrat, Daniel M. Kolansky, Frank E. Silvestry, David Lambert

Publikováno v: Journal of the American College of Cardiology. 73:188

The SCOT-HEART trial recently showed that the use of coronary computed tomography angiography (CCTA) in stable coronary artery disease (CAD) was associated with lower rates of cardiovascular death or nonfatal myocardial infarction compared to standar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::66cdf2b0b9d7104b13f9295bc0fa6345
https://doi.org/10.1016/s0735-1097(19)30796-x

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