Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Ashwin, Govindan"'
Autor:
Anne M. Devlin, Ashutosh Shukla, Julio C. Ruiz, Spencer D. Barnes, Ashwin Govindan, Olga V. Hunter, Anna M. Scarborough, Iván D’Orso, Nicholas K. Conrad
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The PNUTS-PP1 complex directly binds to RNA, and interacts with polymerase II and RNA processing factors to control transcriptional elongation rates and slow polymerase II after polyadenylation sites to promote termination. Using a genome-wide CRISPR
Externí odkaz:
https://doaj.org/article/c1f1e4399fcb427bafd71414e6943423
Publikováno v:
Case Reports in Oncology, Vol 13, Iss 3, Pp 1244-1251 (2020)
Temozolomide (TMZ) is an oral alkylating agent that is considered the standard therapy in primary intracranial malignancies. The medication is well tolerated with a most common side effect of bone marrow suppression that is encountered in a small pro
Externí odkaz:
https://doaj.org/article/5aaa5224c948452a8f16d9bbbe241322
Autor:
Anna R Damato, Ruth G N Katumba, Jingqin Luo, Himachandana Atluri, Grayson R Talcott, Ashwin Govindan, Emily A Slat, Katherine N Weilbaecher, Yu Tao, Jiayi Huang, Omar H Butt, George Ansstas, Tanner M Johanns, Milan G Chheda, Erik D Herzog, Joshua B Rubin, Jian L Campian
Publikováno v:
Neurooncol Pract
Background Gliomas are the most common primary brain tumor in adults. Current treatments involve surgery, radiation, and temozolomide (TMZ) chemotherapy; however, prognosis remains poor and new approaches are required. Circadian medicine aims to maxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15b4e2039f3b8ce558ddbdf3f273ca96
https://doi.org/10.1093/nop/npac003
https://doi.org/10.1093/nop/npac003
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2537
Intron retention (IR) regulates gene expression to control fundamental biological processes like metabolism, differentiation, and cell cycle. Despite a wide variety of genes controlled by IR, few techniques are available to identify regulators of IR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7efe2c4ac895ad6c989e2715d20cec4b
https://pubmed.ncbi.nlm.nih.gov/35895270
https://pubmed.ncbi.nlm.nih.gov/35895270
Publikováno v:
Case Reports in Oncology
Case Reports in Oncology, Vol 13, Iss 3, Pp 1244-1251 (2020)
Case Reports in Oncology, Vol 13, Iss 3, Pp 1244-1251 (2020)
Temozolomide (TMZ) is an oral alkylating agent that is considered the standard therapy in primary intracranial malignancies. The medication is well tolerated with a most common side effect of bone marrow suppression that is encountered in a small pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2079d5426aaf2fd958b9b09bd2cc9ccf
http://europepmc.org/articles/PMC7670352
http://europepmc.org/articles/PMC7670352
Publikováno v:
Methods in Molecular Biology ISBN: 9781071625200
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32b64198fd84b5d56d9fe648d86b0f5c
https://doi.org/10.1007/978-1-0716-2521-7_16
https://doi.org/10.1007/978-1-0716-2521-7_16
Autor:
Tanner M. Johanns, Himachandana Atluri, Melissa A. Meyer, Jiayi Huang, Grayson Talcott, Emily A. Slat, Jian Campian, Joshua B. Rubin, Ashwin Govindan, Yu Tao, Milan G. Chheda
Publikováno v:
Journal of Clinical Oncology. 38:e14525-e14525
e14525 Background: High grade gliomas (HGG) (the most common being glioblastoma) are the most common primary CNS malignancy in adults. Mainstay of therapy is surgical resection followed by concurrent radiation and temozolomide (TMZ) followed by adjuv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bb36b6ad380eb2f1a319ab45c4bdbbc
https://doi.org/10.1200/jco.2020.38.15_suppl.e14525
https://doi.org/10.1200/jco.2020.38.15_suppl.e14525
Publikováno v:
IndraStra Global.
Genetic analysis of the mechanism of protein synthesis in Gram-positive bacteria has remained largely unexplored because of the unavailability of appropriate in vivo assay systems. We developed chloramphenicol acetyltransferase (CAT)-based in vivo re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634c2a3288b420db567725ac8b8547f2
http://eprints.iisc.ac.in/61028/1/Jou_Bac_200-22_2018.pdf
http://eprints.iisc.ac.in/61028/1/Jou_Bac_200-22_2018.pdf
Publikováno v:
Nucleic Acids Research
Living organisms possess two types of tRNAs for methionine. Initiator tRNAs bind directly into the ribosomal P-site to initiate protein synthesis, and the elongators bind to the A-site during the elongation step. Eubacterial initiators (tRNAfMet) are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::376801ac94b76a592122f015cdbbf6cd
https://doi.org/10.1093/nar/gky859
https://doi.org/10.1093/nar/gky859
Publikováno v:
Microbiology (Reading, England). 164(7)
Dihydrofolate reductase (DHFR) and5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) transformylase/IMP cyclohydrolase (PurH) play key roles in maintaining folate pools in cells, and are targets of antimicrobial and anticancer drugs. While the act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bb314a8ab04108a21eb1b15f69cb7ea
https://pubmed.ncbi.nlm.nih.gov/29799386
https://pubmed.ncbi.nlm.nih.gov/29799386