Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Ashwani Kumar Vashishtha"'
Publikováno v:
AIMS Biophysics, Vol 5, Iss 2, Pp 125-143 (2018)
Although Mg2+ is the metal ion that functions as the cofactor for DNA polymerases (DNA pols) in vivo, Mn2+ can also serve in this capacity but it reduces base discrimination. Metal ions aside from Mg2+ or Mn2+ can act as cofactors for some DNA pols b
Externí odkaz:
https://doaj.org/article/cb4475425af74200933662bcc4d7016c
Publikováno v:
2022 International Conference on Fourth Industrial Revolution Based Technology and Practices (ICFIRTP).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5adf26b567ae2860b5b52239b7158d0
https://doi.org/10.1109/icfirtp56122.2022.10059443
https://doi.org/10.1109/icfirtp56122.2022.10059443
Publikováno v:
AIMS Biophysics. 5:125-143
Although Mg2+ is the metal ion that functions as the cofactor for DNA polymerases (DNA pols) in vivo, Mn2+ can also serve in this capacity but it reduces base discrimination. Metal ions aside from Mg2+ or Mn2+ can act as cofactors for some DNA pols b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dba9e54ddadf1f5c6cfdf29756672d4a
https://doi.org/10.3934/biophy.2018.2.125
https://doi.org/10.3934/biophy.2018.2.125
Publikováno v:
Proceedings of 2nd International Conference on Communication, Computing and Networking ISBN: 9789811312168
Cloud environment recent appearance radically amended the opinion regarding infrastructure, software delivery, architectures and development models. Cloud environment provides a number of services, and for which many computing environments exist on a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d159e8ba448b44aa01fe0c55dab435d8
https://doi.org/10.1007/978-981-13-1217-5_6
https://doi.org/10.1007/978-981-13-1217-5_6
Publikováno v:
Biochemistry
The herpes polymerase–processivity factor complex consists of the catalytic UL30 subunit containing both polymerase and proofreading exonuclease activities and the UL42 subunit that acts as a processivity factor. Curiously, the highly active exonuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6fb8bae746ed3f7a3a1d9af2b390476
https://doi.org/10.1021/bi500840v
https://doi.org/10.1021/bi500840v
Although Mg(2+) is the cation that functions as the cofactor for the nucleotidyl transfer reaction for almost all DNA polymerases, Mn(2+) can also serve, but when it does, the degree of base discrimination exhibited by most DNA polymerases (pols) is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1abec268f6bcac62633d5add1b77e25
https://europepmc.org/articles/PMC5989577/
https://europepmc.org/articles/PMC5989577/
Publikováno v:
Biochemistry. 55(7)
We examined the impact of two clinically approved anti-herpes drugs, acyclovir and Forscarnet (phosphonoformate) on the exonuclease activity of the herpes simplex virus-1 DNA polymerase, UL30. Acyclovir triphosphate and Foscarnet, along with the clos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1dae646eb97ec27ec6828fc0ab2373e
https://pubmed.ncbi.nlm.nih.gov/26836009
https://pubmed.ncbi.nlm.nih.gov/26836009
Publikováno v:
Biochemistry. 48:5899-5907
Saccharopine reductase (SR) [saccharopine dehydrogenase (l-glutamate forming), EC 1.5.1.10] catalyzes the condensation of l-alpha-aminoadipate-delta-semialdehyde (AASA) with l-glutamate to give an imine, which is reduced by NADPH to give saccharopine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fc68206c6d0565f141c118dde81c97d
https://doi.org/10.1021/bi900599s
https://doi.org/10.1021/bi900599s
Saccharopine reductase catalyzes the reductive amination of l-α-aminoadipate-δ-semialdehyde with l-glutamate to give saccharopine. Two mechanisms have been proposed for the reductase, one that makes use of enzyme side chains as acid-base catalytic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4ecde1cee53e4eb7311ec37fb5fccc6
https://europepmc.org/articles/PMC4596410/
https://europepmc.org/articles/PMC4596410/
Autor:
Soo Hyun Eom, David Bulkley, Ashwani Kumar Vashishtha, Jimin Wang, Shuangluo Xia, William H. Konigsberg
Publikováno v:
Biochemistry. 51(24)
During DNA synthesis, base stacking and Watson-Crick (WC) hydrogen bonding increase the stability of nascent base pairs when they are in a ternary complex. To evaluate the contribution of base stacking to the incorporation efficiency of dNTPs when a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0c924df773ff80f15846b31eb44930e
https://pubmed.ncbi.nlm.nih.gov/22630605
https://pubmed.ncbi.nlm.nih.gov/22630605