Updating the study protocol: Insight 46 – a longitudinal neuroscience sub-study of the MRC National Survey of Health and Development – phases 2 and 3

Autor: Heidi Murray-Smith, Suzie Barker, Frederik Barkhof, Josephine Barnes, Thomas M. Brown, Gabriella Captur, Molly R.E.Cartlidge, David M. Cash, William Coath, Daniel Davis, John C. Dickson, James Groves, Alun D. Hughes, Sarah-Naomi James, Ashvini Keshavan, Sarah E. Keuss, Josh King-Robson, Kirsty Lu, Ian B. Malone, Jennifer M. Nicholas, Alicja Rapala, Catherine J. Scott, Rebecca Street, Carole H. Sudre, David L. Thomas, Andrew Wong, Selina Wray, Henrik Zetterberg, Nishi Chaturvedi, Nick C. Fox, Sebastian J. Crutch, Marcus Richards, Jonathan M. Schott

Publikováno v: BMC Neurology, Vol 24, Iss 1, Pp 1-21 (2024)

Abstract Background Although age is the biggest known risk factor for dementia, there remains uncertainty about other factors over the life course that contribute to a person’s risk for cognitive decline later in life. Furthermore, the pathological

Externí odkaz: https://doaj.org/article/9fdd7c07f6e74bf4bc709c0fc60fb7cd

Investigating the relationship between BMI across adulthood and late life brain pathologies

Autor: Christopher A. Lane, Josephine Barnes, Jennifer M. Nicholas, John W. Baker, Carole H. Sudre, David M. Cash, Thomas D. Parker, Ian B. Malone, Kirsty Lu, Sarah-Naomi James, Ashvini Keshavan, Sarah Buchanan, Sarah Keuss, Heidi Murray-Smith, Andrew Wong, Elizabeth Gordon, William Coath, Marc Modat, David Thomas, Rebecca Hardy, Marcus Richards, Nick C. Fox, Jonathan M. Schott

Publikováno v: Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-19 (2021)

Abstract Background In view of reported associations between high adiposity, particularly in midlife and late-life dementia risk, we aimed to determine associations between body mass index (BMI), and BMI changes across adulthood and brain structure a

Externí odkaz: https://doaj.org/article/10e2a7dba0b142c4a8c65a142938d773

CSF synaptic protein concentrations are raised in those with atypical Alzheimer’s disease but not frontotemporal dementia

Autor: Mica T. M. Clarke, Ann Brinkmalm, Martha S. Foiani, Ione O. C. Woollacott, Carolin Heller, Amanda Heslegrave, Ashvini Keshavan, Nick C. Fox, Jonathan M. Schott, Jason D. Warren, Kaj Blennow, Henrik Zetterberg, Jonathan D. Rohrer

Publikováno v: Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-9 (2019)

Abstract Background Increased CSF levels of a number of synaptic markers have been reported in Alzheimer’s disease (AD), but little is known about their concentrations in frontotemporal dementia (FTD). We investigated this in three synaptic protein

Externí odkaz: https://doaj.org/article/652930293ccf4a4792d1a9b6d432378e

The global Alzheimer's Association round robin study on plasma amyloid β methods

Autor: Josef Pannee, Leslie M. Shaw, Magdalena Korecka, Teresa Waligorska, Charlotte E. Teunissen, Erik Stoops, Hugo M. J. Vanderstichele, Kimberley Mauroo, Inge M. W. Verberk, Ashvini Keshavan, Pedro Pesini, Leticia Sarasa, Maria Pascual‐Lucas, Noelia Fandos, José‐Antonio Allué, Erik Portelius, Ulf Andreasson, Ritsuko Yoda, Akinori Nakamura, Naoki Kaneko, Shieh‐Yueh Yang, Huei‐Chun Liu, Stefan Palme, Tobias Bittner, Kwasi G. Mawuenyega, Vitaliy Ovod, James Bollinger, Randall J. Bateman, Yan Li, Jeffrey L. Dage, Erik Stomrud, Oskar Hansson, Jonathan M. Schott, Kaj Blennow, Henrik Zetterberg

Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 13, Iss 1, Pp n/a-n/a (2021)

Abstract Introduction Blood‐based assays to measure brain amyloid beta (Aβ) deposition are an attractive alternative to the cerebrospinal fluid (CSF)–based assays currently used in clinical settings. In this study, we examined different blood‐

Externí odkaz: https://doaj.org/article/07cf8801f7b140a6a12154efbdfca507

Adulthood cognitive trajectories over 26 years and brain health at 70 years of age

Autor: Sarah-Naomi James, Jennifer M. Nicholas, Kirsty Lu, Ashvini Keshavan, Christopher A. Lane, Thomas Parker, Sarah M. Buchanan, Sarah E. Keuss, Heidi Murray-Smith, Andrew Wong, David M. Cash, Ian B. Malone, Josephine Barnes, Carole H. Sudre, William Coath, Marc Modat, Sebastien Ourselin, Sebastian J. Crutch, Diana Kuh, Nick C. Fox, Jonathan M. Schott, Marcus Richards

Publikováno v: Neurobiology of Aging, 122, 22-32. Elsevier Inc.
James, S-N, Nicholas, J M, Lu, K, Keshavan, A, Lane, C A, Parker, T, Buchanan, S M, Keuss, S E, Murray-Smith, H, Wong, A, Cash, D M, Malone, I B, Barnes, J, Sudre, C H, Coath, W, Modat, M, Ourselin, S, Crutch, S J, Kuh, D, Fox, N C, Schott, J M & Richards, M 2023, ' Adulthood cognitive trajectories over 26 years and brain health at 70 years of age : findings from the 1946 British Birth Cohort ', Neurobiology of Aging, vol. 122, pp. 22-32 . https://doi.org/10.1016/j.neurobiolaging.2022.10.003

Few studies can address how adulthood cognitive trajectories relate to brain health in 70-year-olds. Participants (n = 468, 49% female) from the 1946 British birth cohort underwent 18F-Florbetapir PET/MRI. Cognitive function was measured in childhood

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aa3a0c083485b229dc407ad9bbb92b7
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