Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Ashvani K. Singh"'
Autor:
Gert de Wilde, Maarten Gees, Sara Musch, Katleen Verdonck, Mia Jans, Anne-Sophie Wesse, Ashvani K. Singh, Tzyh-Chang Hwang, Thierry Christophe, Mathieu Pizzonero, Steven Van der Plas, Nicolas Desroy, Marlon Cowart, Pieter Stouten, Luc Nelles, Katja Conrath
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
The deletion of phenylalanine at position 508 (F508del) in cystic fibrosis transmembrane conductance regulator (CFTR) causes a severe defect in folding and trafficking of the chloride channel resulting in its absence at the plasma membrane of epithel
Externí odkaz:
https://doaj.org/article/8d68380c55104f5f99c3962f9d0c136b
Autor:
C. Tse, Ying Jia, X. Wang, Liu Bo, Douglas M. Cyr, Torben R. Neelands, Wenqing Gao, Xenia B. Searle, Ashvani K. Singh, Timothy A. Vortherms, Hong Y. Ren, Andrew M. Swensen, Corina Balut, Arlene M. Manelli, Sara Alani, Philip R. Kym, K. Conrath, Tzyh Chang Hwang, Yihong Fan
Publikováno v:
J Pharmacol Exp Ther
Cystic fibrosis (CF) is the most common monogenic autosomal recessive disease in Caucasians caused by pathogenic mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene (CFTR). Significant small molecule therapeutic advances
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a61d3189fed304b0edc5967e5538659
https://doi.org/10.1124/jpet.119.261800
https://doi.org/10.1124/jpet.119.261800
Autor:
Wenqing Gao, Robert J. Altenbach, Gang Zhao, John R. Koenig, Greszler Stephen N, Searle Xenia B, Gregory A. Gfesser, Hong Yong, Corina Balut, Marc J. C. Scanio, Yihong Fan, Michael R. Schrimpf, Philip R. Kym, Timothy A. Vortherms, Andrew M. Swensen, Bo Liu, Arlene M. Manelli, Ying Jia, Xueqing Wang, Chris Tse, Andrew Bogdan, Ashvani K. Singh
Publikováno v:
ACS Med Chem Lett
[Image: see text] Cystic fibrosis (CF) is a genetic disorder that affects multiple tissues and organs. CF is caused by mutations in the CFTR gene, resulting in insufficient or impaired cystic fibrosis transmembrane conductance regulator (CFTR) protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::418648a24d9417696c73d206f53310b2
https://doi.org/10.1021/acsmedchemlett.9b00377
https://doi.org/10.1021/acsmedchemlett.9b00377
Autor:
Jianguo Chen, Ashvani K. Singh, Yao Li, Katja Conrath, Jyoti Sharma, Emily Falk Libby, Li Ping Tang, Ning Peng, Steven M. Rowe, Venkateshwar Mutyam
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Am J Respir Cell Mol Biol
Am J Respir Cell Mol Biol
Premature-termination codons (PTCs) in CFTR (cystic fibrosis [CF] transmembrane conductance regulator) result in nonfunctional CFTR protein and are the proximate cause of ∼11% of CF-causing alleles, for which no treatments exist. The CFTR corrector
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b834e3264c71cea70c8d6d3340745e66
https://pubmed.ncbi.nlm.nih.gov/33705685
https://pubmed.ncbi.nlm.nih.gov/33705685
Autor:
A. M. Manelli, Y. Jia, Philip R. Kym, X. Wang, Timothy A. Vortherms, S. Alani, Wenqing Gao, C. Balut, Ashvani K. Singh, Tzyh Chang Hwang, Douglas M. Cyr, H. Y. Ren, Andrew M. Swensen, Y. Fan, Torben R. Neelands, K. Conrath, C. Tse, Xenia B. Searle, Liu Bo
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 374(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90f06a07779c4c9652d155ca898680f4
https://pubmed.ncbi.nlm.nih.gov/31732698
https://pubmed.ncbi.nlm.nih.gov/31732698
Autor:
Ashvani K. Singh, Majid K. Al Salmani, David N. Sheppard, Elvira Sondo, Corina Balut, Nicoletta Pedemonte
Publikováno v:
Studies of Epithelial Transporters and Ion Channels ISBN: 9783030554538
Defective epithelial ion transport is the hallmark of the common life-limiting genetic disease cystic fibrosis (CF). CF is caused by dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR), an ATP-binding cassette transporter, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3277875648d3491e1e77f30bfea92cf2
https://doi.org/10.1007/978-3-030-55454-5_16
https://doi.org/10.1007/978-3-030-55454-5_16
Publikováno v:
Li, H, Pesce, E, Sheppard, D N, Singh, A K & Pedemonte, N 2018, ' Therapeutic approaches to CFTR dysfunction : from discovery to drug development ', Journal of Cystic Fibrosis, vol. 17, no. 2, pp. S14-S21 . https://doi.org/10.1016/j.jcf.2017.08.013
Cystic fibrosis (CF) mutations have complex effects on the cystic fibrosis transmembrane conductance regulator (CFTR) protein. They disrupt its processing to and stability at the plasma membrane and function as an ATP-gated Cl− channel. Here, we re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f96ef9086f63d077ed02dafc9827e18
https://doi.org/10.1016/j.jcf.2017.08.013
https://doi.org/10.1016/j.jcf.2017.08.013
Autor:
Searle Xenia B, Wenqing Gao, Andrew M. Swensen, Timothy A. Vortherms, Hong Yong, Clinton Yeung, Corina Balut, Philip R. Kym, Yihong Fan, Ashvani K. Singh, Greszler Stephen N, Kelly E. Desino, Andrew Bogdan, Ying Jia, Chris Tse, Xueqing Wang, Bo Liu
Publikováno v:
Journal of Medicinal Chemistry. 61:1436-1449
Cystic fibrosis (CF) is a multiorgan disease of the lungs, sinuses, pancreas, and gastrointestinal tract that is caused by a dysfunction or deficiency of the cystic fibrosis transmembrane conductance regulator (CFTR) protein, an epithelial anion chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7451d4d615499d205ff8e0f34d896f9a
https://doi.org/10.1021/acs.jmedchem.7b01339
https://doi.org/10.1021/acs.jmedchem.7b01339
Autor:
Anne Sophie Wesse, Nicolas Desroy, Mathieu Rafaël Pizzonero, Mia Jans, Steven Emiel Van Der Plas, Katleen Verdonck, Katja Conrath, Tzyh Chang Hwang, Ashvani K. Singh, Gert Jules Hector De Wilde, Thierry Christophe, Pieter F. W. Stouten, Maarten Gees, Luc Nelles, Sara Musch, Marlon Cowart
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Frontiers in Pharmacology
Frontiers in Pharmacology
The deletion of phenylalanine at position 508 (F508del) in cystic fibrosis transmembrane conductance regulator (CFTR) causes a severe defect in folding and trafficking of the chloride channel resulting in its absence at the plasma membrane of epithel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4d914b2d0b2021abba128959645f2bf
https://www.frontiersin.org/article/10.3389/fphar.2019.00514/full
https://www.frontiersin.org/article/10.3389/fphar.2019.00514/full
Novel Pseudomonas aeruginosa Quorum-Sensing Inhibitors Identified in an Ultra-High-Throughput Screen
Publikováno v:
Antimicrobial Agents and Chemotherapy. 50:3674-3679
The opportunistic pathogen Pseudomonas aeruginosa has two complete acyl-homoserine lactone (acyl-HSL) signaling systems, LasR-LasI and RhlR-RhlI. LasI catalyzes the synthesis of N -3-oxododecanoyl homoserine lactone (3OC12-HSL), and LasR is a transcr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64b51c34f389df0b7650a4011c830b67
https://doi.org/10.1128/aac.00665-06
https://doi.org/10.1128/aac.00665-06