Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Ashutosh S. Phadte"'
Publikováno v:
Antioxidants, Vol 10, Iss 7, p 1001 (2021)
The chaperone and anti-apoptotic activity of α-crystallins (αA- and αB-) and their derivatives has received increasing attention due to their tremendous potential in preventing cell death. While originally known and described for their role in the
Externí odkaz:
https://doaj.org/article/ff44798f61064316b2ac5615ccae6ee6
Publikováno v:
Biochemistry
The G98R mutation in αA-crystallin is associated with the onset of pre-senile cataract and is characterized biochemically by an increased oligomeric mass, altered chaperone function, and loss of structural stability over time. Thus far, it is not kn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed4d8b14b5cbd9267c3b5c3bb14dc230
https://doi.org/10.1021/acs.biochem.9b00374
https://doi.org/10.1021/acs.biochem.9b00374
Autor:
K. Krishna Sharma, Peter F. Kador, Ashutosh S. Phadte, Marjorie F. Lou, Puttur Santhoshkumar, Damian M. Daszynski, Haizhen A. Zhong
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports
The paradigm that cataracts are irreversible and that vision from cataracts can only be restored through surgery has recently been challenged by reports that oxysterols such as lanosterol and 25-hydroxycholesterol can restore vision by binding to αB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f48cba3f41f04ae1fafb52d4b945629
http://link.springer.com/article/10.1038/s41598-019-44676-4
http://link.springer.com/article/10.1038/s41598-019-44676-4
Autor:
Madhu Nath, Zachary B. Sluzala, Ashutosh S. Phadte, Yang Shan, Angela M. Myers, Patrice E. Fort
Publikováno v:
eneuro. 9:ENEURO.0045-22.2022
Expression and secretion of neurotrophic factors have long been known as a key mechanism of neuroglial interaction in the central nervous system. In addition, several other intrinsic neuroprotective pathways have been described, including those invol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::440fb859687bc057371e26f62b24a2fe
https://doi.org/10.1523/eneuro.0045-22.2022
https://doi.org/10.1523/eneuro.0045-22.2022
Publikováno v:
Molecular Vision
Purpose The G98R mutant of αA-crystallin is associated with the development of presenile cataracts. In vitro, the recombinant mutant protein exhibits altered structural and functional characteristics, along with the propensity to aggregate by itself
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a7ce6c85599c47130117565b98201e25
https://pubmed.ncbi.nlm.nih.gov/29706763
https://pubmed.ncbi.nlm.nih.gov/29706763