Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Ashutosh Hardikar"'
Publikováno v:
Journal of Cardiothoracic Surgery, Vol 19, Iss 1, Pp 1-5 (2024)
Abstract Background Post-Operative Atrial Fibrillation (POAF) is the most frequent complication of cardiac surgery and is associated with reduced survival, increased rates of cognitive changes and cerebrovascular accidents, heart failure, renal dysfu
Externí odkaz:
https://doaj.org/article/8fba2d9cea4341dd8533e7488de8e280
Autor:
Prem Bhattarai, Wenying Lu, Ashutosh Hardikar, Surajit Dey, Archana Vijay Gaikwad, Affan Mahmood Shahzad, Collin Chia, Andrew Williams, Gurpreet Kaur Singhera, Tillie-Louise Hackett, Mathew Suji Eapen, Sukhwinder Singh Sohal
Publikováno v:
ERJ Open Research, Vol 10, Iss 1 (2024)
Background We have previously reported pulmonary arterial remodelling in smokers and patients with early COPD, which can be attributed to endothelial to mesenchymal transition (EndMT). In this study, we aimed to evaluate if EndMT is an active mechani
Externí odkaz:
https://doaj.org/article/bb5fe1dc35c645afbd125122e5bbbdf6
Autor:
Wenying Lu, Mathew Suji Eapen, Ashutosh Hardikar, Collin Chia, Iain Robertson, Gurpreet Kaur Singhera, Tillie L. Hackett, Sukhwinder Singh Sohal
Publikováno v:
ERJ Open Research, Vol 9, Iss 6 (2023)
Background Epithelial–mesenchymal transition (EMT) might be central to lung cancer development in smokers and COPD. We illustrate EMT changes in a broader demographic of patient groups who were diagnosed with nonsmall cell lung cancer (adenocarcino
Externí odkaz:
https://doaj.org/article/d565a218566142e5adbcfe18992f330c
Autor:
Samuel James Brake, Wenying Lu, Collin Chia, Greg Haug, Josie Larby, Ashutosh Hardikar, Gurpreet K. Singhera, Tillie L. Hackett, Mathew Suji Eapen, Sukhwinder Singh Sohal
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundCOPD is a common disease characterized by respiratory airflow obstruction. TGF-β1 and SMAD pathway is believed to play a role in COPD pathogenesis by driving epithelial mesenchymal transition (EMT).MethodsWe investigated TGF-β1 signalling
Externí odkaz:
https://doaj.org/article/1785ac62c9de46619da72af6e7aa262d
Autor:
Prem Bhattarai, Wenying Lu, Archana Vijay Gaikwad, Surajit Dey, Collin Chia, Josie Larby, Greg Haug, Ashutosh Hardikar, Andrew Williams, Gurpreet Kaur Singhera, Tillie-Louise Hackett, Mathew Suji Eapen, Sukhwinder Singh Sohal
Publikováno v:
ERJ Open Research, Vol 8, Iss 4 (2022)
Introduction Pulmonary vascular remodelling in chronic obstructive pulmonary disease (COPD) has detrimental consequences for lung physiology. The aim of our study was to provide a comprehensive size-based morphometric quantification of pulmonary arte
Externí odkaz:
https://doaj.org/article/52836600fe7a4a06ad575edb484c53ab
Autor:
Mathew Suji Eapen, Wenying Lu, Tillie L. Hackett, Gurpreet Kaur Singhera, Malik Q. Mahmood, Ashutosh Hardikar, Chris Ward, Eugene Haydn Walters, Sukhwinder Singh Sohal
Publikováno v:
ERJ Open Research, Vol 7, Iss 2 (2021)
Introduction Previous reports have shown epithelial–mesenchymal transition (EMT) as an active process that contributes to small airway fibrotic pathology. Myofibroblasts are highly active pro-fibrotic cells that secrete excessive and altered extrac
Externí odkaz:
https://doaj.org/article/324e6043abea45729e637881b5173bb3
Publikováno v:
SAGE Open Medical Case Reports, Vol 7 (2019)
Functional paragangliomas are rare neuroendocrine tumours that secrete catecholamines and are infrequently found in the mediastinum. We report a case of a young male with symptoms of catecholamine excess and a personal and family history of the parag
Externí odkaz:
https://doaj.org/article/081ee26ccd1a4558bab7d5188caf30c7
Publikováno v:
Heart Vessels and Transplantation, Vol 2, Iss 1 (2018)
Externí odkaz:
https://doaj.org/article/b3b8008e386547348f33d546dc65b353
Publikováno v:
Heart Vessels and Transplantation, Vol 2, Iss 1 (2018)
Externí odkaz:
https://doaj.org/article/e2b01340ead74025931a5dda7724cb70
Autor:
Ashutosh Hardikar, Robin Harle
Publikováno v:
Heart, Lung and Circulation. 30:1058-1066
Background Bicuspid aortic valves (BAV) and related aortopathy remain an intriguing topic. Not all BAVs get diseased and around 40% would develop aortic dilatation in their lifetime. If haemodynamic theory is to be believed, then leaflet fusion patte