Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Ashu Shah"'
Autor:
Pranita Atri, Ashu Shah, Gopalakrishnan Natarajan, Satyanarayana Rachagani, Sanchita Rauth, Koelina Ganguly, Joseph Carmicheal, Dario Ghersi, Jesse L. Cox, Lynette M. Smith, Maneesh Jain, Sushil Kumar, Moorthy P. Ponnusamy, Parthasarathy Seshacharyulu, Surinder K. Batra
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-15 (2024)
Abstract Pancreatic ductal adenocarcinoma (PDAC) remains highly lethal due to limited therapeutic options and expensive/burdensome drug discovery processes. Utilizing genomic-data-driven Connectivity Mapping (CMAP) to identify a drug closer to real-w
Externí odkaz:
https://doaj.org/article/27698b79b7aa49419b969e281158a44b
Autor:
Ashu Shah, Sanjib Chaudhary, Imayavaramban Lakshmanan, Abhijit Aithal, Sophia G. Kisling, Claire Sorrell, Saravanakumar Marimuthu, Shailendra K. Gautam, Sanchita Rauth, Prakash Kshirsagar, Jesse L. Cox, Gopalakrishnan Natarajan, Rakesh Bhatia, Kavita Mallya, Satyanarayana Rachagani, Mohd Wasim Nasser, Apar Kishor Ganti, Ravi Salgia, Sushil Kumar, Maneesh Jain, Moorthy P. Ponnusamy, Surinder K. Batra
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-16 (2023)
Abstract Aberrantly expressed onco-mucin 16 (MUC16) and its post-cleavage generated surface tethered carboxy-terminal (MUC16-Cter) domain are strongly associated with poor prognosis and lethality of pancreatic (PC) and non-small cell lung cancer (NSC
Externí odkaz:
https://doaj.org/article/32f677e6e7f342b1a84bc4cad2938d3b
Autor:
Sanjib Chaudhary, Muthamil Iniyan Appadurai, Shailendra Kumar Maurya, Palanisamy Nallasamy, Saravanakumar Marimuthu, Ashu Shah, Pranita Atri, Chirravuri Venkata Ramakanth, Subodh M. Lele, Parthasarathy Seshacharyulu, Moorthy P. Ponnusamy, Mohd W. Nasser, Apar Kishor Ganti, Surinder K. Batra, Imayavaramban Lakshmanan
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-15 (2023)
Abstract Background Triple-negative breast cancer (TNBC) is highly aggressive with an increased metastatic incidence compared to other breast cancer subtypes. However, due to the absence of clinically reliable biomarkers and targeted therapy in TNBC,
Externí odkaz:
https://doaj.org/article/c89f442b49cf48b58554e7cbf76ee1f0
Autor:
Koelina, Ganguly, Ashu, Shah, Pranita, Atri, Sanchita, Rauth, Moorthy P, Ponnusamy, Sushil, Kumar, Surinder K, Batra
Publikováno v:
Seminars in Cancer Biology. 86:511-520
Pancreatic cancer (PC) is exemplified by a complex immune-suppressive, fibrotic tumor microenvironment (TME), and aberrant expression of mucins. The constant crosstalk between cancer cells, cancer-associated fibroblasts (CAFs), and the immune cells m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4079d1b650662f58721a5db44332ad53
https://doi.org/10.1016/j.semcancer.2022.03.022
https://doi.org/10.1016/j.semcancer.2022.03.022
Autor:
Imayavaramban Lakshmanan, Saravanakumar Marimuthu, Sanjib Chaudhary, Parthasarathy Seshacharyulu, Satyanarayana Rachagani, Sakthivel Muniyan, Ramakanth Chirravuri-Venkata, Pranita Atri, Sanchita Rauth, Rama Krishna Nimmakayala, Jawed Akhtar Siddiqui, Shailendra K. Gautam, Ashu Shah, Gopalakrishnan Natarajan, Seema Parte, Namita Bhyravbhatla, Kavita Mallya, Dhanya Haridas, Geoffrey A. Talmon, Lynette M. Smith, Sushil Kumar, Apar Kishor Ganti, Maneesh Jain, Moorthy P. Ponnusamy, Surinder K. Batra
Publikováno v:
Oncogene
MUC16, membrane-bound mucin, plays an oncogenic role in pancreatic ductal adenocarcinoma (PDAC). However, the pathological role of MUC16 in the PDAC progression, tumor microenvironment, and metastasis in cooperation with Kras(G12D) and Trp53(R172H) m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::278ab0d89c58575801acb946fe049053
https://doi.org/10.1038/s41388-022-02493-6
https://doi.org/10.1038/s41388-022-02493-6
Autor:
Surinder K. Batra, Moorthy P. Ponnusamy, Maneesh Jain, Kaustubh Datta, Michael A. Hollingsworth, Paul M. Grandgenett, Kavita Mallya, Namita Bhyravbhatla, Ashu Shah, Pranita Atri, Sanchita Rauth, Rama Krishna Nimmakayala, Shailendra K. Gautam, Sakthivel Muniyan, Imayavaramban Lakshmanan, Saravanakumar Marimuthu
Supplementary Figure from MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::612e6f6acc48f12e69ba799ed47501b6
https://doi.org/10.1158/1541-7786.22527485
https://doi.org/10.1158/1541-7786.22527485
Autor:
Surinder K. Batra, Moorthy P. Ponnusamy, Maneesh Jain, Kaustubh Datta, Michael A. Hollingsworth, Paul M. Grandgenett, Kavita Mallya, Namita Bhyravbhatla, Ashu Shah, Pranita Atri, Sanchita Rauth, Rama Krishna Nimmakayala, Shailendra K. Gautam, Sakthivel Muniyan, Imayavaramban Lakshmanan, Saravanakumar Marimuthu
Supplementary Table from MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::037098025e7ef6f3cb03f9f42858a9fd
https://doi.org/10.1158/1541-7786.22527482.v1
https://doi.org/10.1158/1541-7786.22527482.v1
Autor:
Saravanakumar Marimuthu, Imayavaramban Lakshmanan, Sakthivel Muniyan, Shailendra K. Gautam, Rama Krishna Nimmakayala, Sanchita Rauth, Pranita Atri, Ashu Shah, Namita Bhyravbhatla, Kavita Mallya, Paul M. Grandgenett, Michael A. Hollingsworth, Kaustubh Datta, Maneesh Jain, Moorthy P. Ponnusamy, Surinder K. Batra
Publikováno v:
Mol Cancer Res
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal types of cancer, as it commonly metastasizes to the liver resulting in an overall poor prognosis. However, the molecular mechanism involved in liver metastasis remains poorly understoo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fcc28d638d67fe38adeb3356df455aa
https://doi.org/10.1158/1541-7786.mcr-21-0888
https://doi.org/10.1158/1541-7786.mcr-21-0888
Autor:
Sanjib Chaudhary, Shailendra Kumar Maurya, Palanisamy Nallasamy, Marimuthu Saravanakumar, Ashu Shah, Pranita Atri, Chirravuri Venkata Ramakanth, Subodh M. Lele, Parthasarathy Seshacharyulu, Moorthy P. Ponnusamy, Mohd W. Nasser, Surinder K. Batra, Imayavaramban Lakshmanan
Background: Triple-negative breast cancer (TNBC) is highly aggressive with an increased metastatic incidence compared to other breast cancer subtypes. However, due to the absence of clinically reliable biomarkers and targeted therapy in TNBC, chemoth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f21fee5015fd81ab20f16e76cbd4b2e
https://doi.org/10.21203/rs.3.rs-1735717/v1
https://doi.org/10.21203/rs.3.rs-1735717/v1
Autor:
Chunmeng Zhang, Pranita Atri, Palanisamy Nallasamy, Seema Parte, Sanchita Rauth, Rama Krishna Nimmakayala, Saravanakumar Marimuthu, Ramakanth Chirravuri-Venkata, Rakesh Bhatia, Sushanta Halder, Ashu Shah, Jesse L. Cox, Lynette Smith, Sushil Kumar, Jason M. Foster, Rakesh C. Kukreja, Parthasarathy Seshacharyulu, Moorthy P. Ponnusamy, Surinder K. Batra
Publikováno v:
Cancer letters. 551
Mucin MUC4 is an aberrantly expressed oncogene in pancreatic ductal adenocarcinoma (PDAC), yet no pharmacological inhibitors have been identified to target MUC4. Here, we adapted an in silico screening method using the Cancer Therapeutic Response Dat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d62dda2508cf7eb8d11c85a3263ecff
https://pubmed.ncbi.nlm.nih.gov/36285687
https://pubmed.ncbi.nlm.nih.gov/36285687