Synthesis and characterisation of new fluorescent Na+ and K+ indicators

Autor: Georges J. Hoornaert, Ashty Saleh, Els Cielen, Noël Boens, Abdellah Tahri, Katja Ver Heyen

Publikováno v: Tetrahedron. 55:5207-5226

The synthesis of new fluorescent indicators for Na+, Benz-15-5 or Diaz-15-5, and for K+, Benz-18-6 or Diaz-18-6, respectively, is reported. They consist of a benzocrown or a diazacrown ether linked to a pyrazoline fluorophore substituted with carboxy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ba035a4862ff0fd38bff16e78751b7f
https://doi.org/10.1016/s0040-4020(99)00167-2

The Synthesis of 2,7-Substituted Octahydro-2H-Pyrido[1,2-a] Pyrazines, Analogues of Quinolizidine and Piperazine Drugs

Autor: M. Ashty Saleh, Georges J. Hoornaert, Frans Compernolle, Suzanne Toppet

Publikováno v: Tetrahedron. 50:1811-1820

The versatility of amino ketone 2 (2-benzyloctahydro-2H-pyrido[1,2-a]pyrazin-7-one) was demonstrated by the synthesis of 2,7-substituted derivatives, designed as analogues of both quinolizidine and piperazine drugs. The 7- ketone group was functional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e76c2a98003fdce9fbb5128fe3b0c652
https://doi.org/10.1016/s0040-4020(01)80853-x

An entry into the novel tetracyclic system 6H-pyrido[1′,2′:4,5]pyrazino[1,2-a]benzimidazole. Synthesis and conformational study of the 1,2,3,4,13,13a-hexahydro-3,3-ethylenedioxy and 3-ketone derivatives

Autor: Wim De Buysser, Suzanne Toppet, Georges J. Hoornaert, M. Ashty Saleh, Frans Compernolle

Publikováno v: Journal of Heterocyclic Chemistry. 28:1965-1969

The synthesis of the tetracyclic title compounds, acetal 5 and ketone 6, is presented. The key step, formation of the imidazole ring to give compound 5, involved the acid catalysed dehydration of the 2-(o-aminophenyl)lactam 7b. This was generated fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::07068fc77d99bb011dc52931bbabf67f
https://doi.org/10.1002/jhet.5570280829

Regioselective oxidation of piperidine-3 derivatives: a synthetic route to 2,5-substituted piperidines

Autor: Frans Compernolle, Stefan Van den Branden, Suzanne Toppet, M. Ashty Saleh, Georges J. Hoornaert

Publikováno v: The Journal of Organic Chemistry. 56:2386-2390

Mercuric acetate oxidation of 1-benzyl-3,3-(ethylenedioxy) piperidine (1) and of 3-CO 2 Et- and 3-CH 2 OH-substituted piperidines 7-9 was shown to occur regioselectively at the 6-position. Trapping of the resulting 6-iminium ions with cyanide yielded

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::08816be82a67b2e0dde6552b4a2c03af
https://doi.org/10.1021/jo00007a025

Abstracts of papers Symposium 'new therapeutic developments in human infectious diseases'

Autor: D. A. H. v. Maarschalkerwaart, N. Auzeil, L. Christiaens, H. Robaux, D. Schols, A. M. Ouero, Marcel J.E. Fischer, P. Wigerinck, P. Herdewiin, R. Bonaly, G. J. Koomen, M. Hooper, H. Galone, G. Schepers, E. De Clercg, F. A. W. Koeman, J. P. Kamerlina, J. P. Kamerling, S. Tounson, P. Claes, Hugo Vanden Bossche, G. Bram, J. Marchand-Brynaert, S. Labidalle, J. F. G. Vlieqenthart, R. Pauwels, E. De Vos, M. Baba, R. A. Dommisse, Carl H. Schwabe, Jaap Wilting, Georges J. Hoornaert, F. R. Opperdoes, F. Verberckmoes, H. Schellekens, J. A. Liepoivre, B. H. M. Mruthyunjayasuamy, W. G. J. Hol, Fred R. Opperdoes, J. Osuku Opio, A. F. M. Verheul, J. Cntto, N. De Meyer, L. Mishra, Octaaf J.M. Bos, D. Vanden Berghe, H. Snippe, Lambert H.M. Janssen, D. Van Der Taelen, Ashty Saleh, Ei. Esmans, E. L. Esmans, Frans Compernolle, Isabelle Coppens, J. L. Monal, M. Miocque, F. C. Alderweireldt, A. Jakobs, T. M. Slaghek, P. Joos, S. P. Hiremath, J. Balzarini, M. Renson, P. Herdewi in, Eugene L.M. Vansterkenburg, W. Van Dongen, A. Haemers, H. K. Pandey, L. Plaum, M. J. Wanner, A. Van Aerschot, J. A. Lepoivre, M. Q. Zhang, A. J. Vlietinck, H. Galons, N. Damianos, E. De Clercq, I. Nasri, V. Loppinet

Publikováno v: Pharmaceutisch Weekblad. 11:C3-C9

s of papers Symposium "New therapeutic developments in human infectious diseases" Organized by the Division Medicinal Chemistry of the Royal Dutch Chemistry Society (Sectie Farmacochemie van de Koninklijke Nederlandse Chemische Vereniging) and the Co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c667bc2fdd8d9b6b8704febb0262c8c9
https://doi.org/10.1007/bf02196043