Optimization of pyrazolopyridine 4-carboxamides with potent antimalarial activity for which resistance is associated with the P. falciparum transporter ABCI3.

Autor: Calic PPS; The Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, 3010, Australia., Ashton TD; The Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, 3010, Australia., Mansouri M; The Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, 3010, Australia., Loi K; The Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, 3010, Australia., Jarman KE; The Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, 3010, Australia., Qiu D; Research School of Biology, Australian National University, Canberra, 2601, Australia., Lehane AM; Research School of Biology, Australian National University, Canberra, 2601, Australia., Roy S; TCG Lifesciences, Kolkata, West Bengal, 700091, India., Rao GP; TCG Lifesciences, Kolkata, West Bengal, 700091, India., Maity B; TCG Lifesciences, Kolkata, West Bengal, 700091, India., Wittlin S; Swiss Tropical and Public Health Institute, Kreuzstrasse 2, 4123, Allschwil, Switzerland; University of Basel, 4003, Basel, Switzerland., Crespo B; Global Health Medicines R&D, GSK, Tres Cantos, 28760, Spain., Gamo FJ; Global Health Medicines R&D, GSK, Tres Cantos, 28760, Spain., Deni I; Department of Microbiology & Immunology, Columbia University, Irving Medical Center, New York, 10032, NY, USA; Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University, Irving Medical Center, New York, 10032, NY, USA., Fidock DA; Department of Microbiology & Immunology, Columbia University, Irving Medical Center, New York, 10032, NY, USA; Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University, Irving Medical Center, New York, 10032, NY, USA., Chowdury M; School of Medicine, Deakin University, Waurn Ponds, Victoria, 3216, Australia; Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, Victoria, 3216, Australia., de Koning-Ward TF; School of Medicine, Deakin University, Waurn Ponds, Victoria, 3216, Australia; Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, Victoria, 3216, Australia., Cowman AF; The Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, 3010, Australia., Jackson PF; Global Public Health, Janssen R&D LLC, La Jolla, 92121, USA., Baud D; MMV Medicines for Malaria Venture, ICC, Route de Pré-Bois 20, 1215, Geneva, Switzerland., Brand S; MMV Medicines for Malaria Venture, ICC, Route de Pré-Bois 20, 1215, Geneva, Switzerland., Laleu B; MMV Medicines for Malaria Venture, ICC, Route de Pré-Bois 20, 1215, Geneva, Switzerland., Sleebs BE; The Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, 3010, Australia. Electronic address: sleebs@wehi.edu.au.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2024 Oct 05; Vol. 276, pp. 116677. Date of Electronic Publication: 2024 Jul 14.

Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4.

Autor: Ashton TD; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia., Calic PPS; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia., Dans MG; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia., Ooi ZK; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia., Zhou Q; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia., Palandri J; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia., Loi K; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia., Jarman KE; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia., Qiu D; Research School of Biology, Australian National University, Canberra 2601, Australia., Lehane AM; Research School of Biology, Australian National University, Canberra 2601, Australia., Maity BC; TCG Lifesciences, Kolkata, West Bengal 700091, India., De N; TCG Lifesciences, Kolkata, West Bengal 700091, India., Giannangelo C; Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia., MacRaild CA; Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia., Creek DJ; Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia., Mao EY; Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide 5005, Australia., Gancheva MR; Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide 5005, Australia., Wilson DW; Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide 5005, Australia., Chowdury M; School of Medicine, Deakin University, Waurn Ponds, Victoria 3216, Australia.; Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, Victoria 3216, Australia., de Koning-Ward TF; School of Medicine, Deakin University, Waurn Ponds, Victoria 3216, Australia.; Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, Victoria 3216, Australia., Famodimu MT; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, U.K., Delves MJ; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, U.K., Pollard H; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, U.K., Sutherland CJ; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, U.K., Baud D; MMV Medicines for Malaria Venture, ICC, Route de Pré-Bois 20, Geneva 1215, Switzerland., Brand S; MMV Medicines for Malaria Venture, ICC, Route de Pré-Bois 20, Geneva 1215, Switzerland., Jackson PF; Emerging Science & Innovation, Discovery Sciences, Janssen R&D LLC, La Jolla, California 92121, United States., Cowman AF; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia., Sleebs BE; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Aug 22; Vol. 67 (16), pp. 14493-14523. Date of Electronic Publication: 2024 Aug 12.

Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4.

Autor: Ashton TD; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia., Dans MG; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia., Favuzza P; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia., Ngo A; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia., Lehane AM; Research School of Biology, Australian National University, Canberra 2601, Australia., Zhang X; Research School of Biology, Australian National University, Canberra 2601, Australia., Qiu D; Research School of Biology, Australian National University, Canberra 2601, Australia., Chandra Maity B; TCG Lifesciences Pvt. Ltd., Saltlake Sec-V, Kolkata 700091, West Bengal, India., De N; TCG Lifesciences Pvt. Ltd., Saltlake Sec-V, Kolkata 700091, West Bengal, India., Schindler KA; Department of Microbiology & Immunology, Columbia University, Irving Medical Center, New York, New York 10032, United States., Yeo T; Department of Microbiology & Immunology, Columbia University, Irving Medical Center, New York, New York 10032, United States., Park H; Department of Microbiology & Immunology, Columbia University, Irving Medical Center, New York, New York 10032, United States., Uhlemann AC; Department of Microbiology & Immunology, Columbia University, Irving Medical Center, New York, New York 10032, United States., Churchyard A; Department of Life Sciences, Imperial College London, South Kensington SW7 2AZ U.K., Baum J; Department of Life Sciences, Imperial College London, South Kensington SW7 2AZ U.K.; School of Biomedical Sciences, University of New South Wales, Sydney 2031, Australia., Fidock DA; Department of Microbiology & Immunology, Columbia University, Irving Medical Center, New York, New York 10032, United States.; Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University, Irving Medical Center, New York, New York 10032, United States., Jarman KE; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia., Lowes KN; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia., Baud D; Medicines for Malaria Venture, ICC, Route de Pré-Bois 20, 1215 Geneva, Switzerland., Brand S; Medicines for Malaria Venture, ICC, Route de Pré-Bois 20, 1215 Geneva, Switzerland., Jackson PF; Global Public Health, Janssen R&D LLC, La Jolla, California 92121, United States., Cowman AF; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia., Sleebs BE; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2023 Mar 09; Vol. 66 (5), pp. 3540-3565. Date of Electronic Publication: 2023 Feb 22.

Nickel-Catalyzed C-N Cross-Coupling of 4-Chloro-1,8-naphthalimides and Bulky, Primary Alkylamines at Room Temperature.

Autor: Tassone JP; Department of Chemistry, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada., Lundrigan T; Department of Chemistry, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada., Ashton TD; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia., Stradiotto M; Department of Chemistry, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada.

Publikováno v: The Journal of organic chemistry [J Org Chem] 2022 May 06; Vol. 87 (9), pp. 6492-6498. Date of Electronic Publication: 2022 Apr 20.

Effect of Triton X-100 on the Activity and Selectivity of Lipase Immobilized on Chemically Reduced Graphene Oxides.

Autor: Ramakrishna TRB; School of Life and Environmental Sciences, Deakin University, 75 Pigdons Road, Waurn Ponds, Victoria 3216, Australia.; Seafood Unit, The New Zealand Institute for Plant & Food Research Limited, 293-297 Akersten Street, Nelson 7010, New Zealand., Ashton TD; School of Life and Environmental Sciences, Deakin University, 75 Pigdons Road, Waurn Ponds, Victoria 3216, Australia., Marshall SN; Seafood Unit, The New Zealand Institute for Plant & Food Research Limited, 293-297 Akersten Street, Nelson 7010, New Zealand., Nalder TD; School of Life and Environmental Sciences, Deakin University, 75 Pigdons Road, Waurn Ponds, Victoria 3216, Australia.; Seafood Unit, The New Zealand Institute for Plant & Food Research Limited, 293-297 Akersten Street, Nelson 7010, New Zealand., Yang W; School of Life and Environmental Sciences, Deakin University, 75 Pigdons Road, Waurn Ponds, Victoria 3216, Australia., Barrow CJ; School of Life and Environmental Sciences, Deakin University, 75 Pigdons Road, Waurn Ponds, Victoria 3216, Australia.

Publikováno v: Langmuir : the ACS journal of surfaces and colloids [Langmuir] 2021 Aug 03; Vol. 37 (30), pp. 9202-9214. Date of Electronic Publication: 2021 Jul 21.